TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling

SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury

(2021) Jin-Ze Tian et al.   Scientific Reports

The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

(2021) Zhenzhen Yan et al.   Cell Reports

Human DNA-PK activates a STING-independent DNA sensing pathway

(2020) Katelyn Burleigh et al.   Science Immunology

TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination

(2020) Meng Deng et al.   Nature Communications

A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

(2019) Baoyu Zhao et al.   NATURE

SET domain-containing protein 4 epigenetically controls breast cancer stem cell quiescence

(2019) Sen Ye et al.   CANCER RESEARCH

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

The importance of non-histone protein methylation in cancer therapy

(2019) Manuel Rodríguez-Paredes et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages

(2019) Yuyun Zhong et al.   MOLECULAR IMMUNOLOGY

KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly

(2019) Yi Liu et al.   Cells

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells

(2017) Shouheng Jin et al.   MOLECULAR CELL

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

(2017) Qian Zhang et al.   NATURE CELL BIOLOGY

The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution

(2017) Peng Yang et al.   TRENDS IN GENETICS

Post-translational Control of Intracellular Pathogen Sensing Pathways

(2017) Cindy Chiang et al.   TRENDS IN IMMUNOLOGY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia

(2016) Li Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome

(2016) Meng Lin et al.   MOLECULAR CELL

E3 ubiquitin ligase RNF128 promotes innate antiviral immunity through K63-linked ubiquitination of TBK1

(2016) Guanhua Song et al.   NATURE IMMUNOLOGY

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

(2016) Xia Li et al.   NATURE IMMUNOLOGY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

RIG-I-like receptor regulation in virus infection and immunity

(2015) Ying Kai Chan et al.   Current Opinion in Virology

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

(2014) Bin Shen et al.   NATURE METHODS

KRAB-Zinc Finger Proteins: A Repressor Family Displaying Multiple Biological Functions

(2013) Angelo Lupo et al.   CURRENT GENOMICS

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

(2013) Amede Larabi et al.   Cell Reports

The Zinc Finger Protein ZNF268 Is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling

(2012) Wei Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Embryonic stem cells use ZFP809 to silence retroviral DNAs

(2009) Daniel Wolf et al.   NATURE

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY