An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512

Catalytic Metal Ions and Enzymatic Processing of DNA and RNA

(2015) Giulia Palermo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Novel DNA Topoisomerase IIα Inhibitors from Combined Ligand- and Structure-Based Virtual Screening

(2014) Malgorzata N. Drwal et al.   PLoS One

Recent Developments of DNA Poisons - Human DNA Topoisomerase IIα Inhibitors - as Anticancer Agents

(2013) Barbara Pogorelcnik et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular Simulations Highlight the Role of Metals in Catalysis and Inhibition of Type II Topoisomerase

(2013) Giulia Palermo et al.   Journal of Chemical Theory and Computation

F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity

(2013) A Kruczynski et al.   LEUKEMIA

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

(2013) Chyuan-Chuan Wu et al.   NUCLEIC ACIDS RESEARCH

The antitumor drug F14512 enhances cisplatin and ionizing radiation effects in head and neck squamous carcinoma cell lines

(2013) F. Mouawad et al.   ORAL ONCOLOGY

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage

(2011) Amanda C. Gentry et al.   BIOCHEMISTRY

Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide

(2011) C.-C. Wu et al.   SCIENCE

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Topoisomerases and site-specific recombinases: similarities in structure and mechanism

(2010) Wei Yang   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Bridging quantum mechanics and structure-based drug design

(2010) Marco De Vivo   Frontiers in Bioscience-Landmark

Single-Molecule Pulling Simulations Can Discern Active from Inactive Enzyme Inhibitors

(2010) Francesco Colizzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The use of divalent metal ions by type II topoisomerases

(2010) Joseph E. Deweese et al.   Metallomics

A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases

(2010) Bryan H. Schmidt et al.   NATURE

Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases

(2010) Ivan Laponogov et al.   PLoS One

Use of Divalent Metal Ions in the DNA Cleavage Reaction of Human Type II Topoisomerases†

(2009) Joseph E. Deweese et al.   BIOCHEMISTRY

Metal Ion Interactions in the DNA Cleavage/Ligation Active Site of Human Topoisomerase IIα

(2009) Joseph E. Deweese et al.   BIOCHEMISTRY

DNA topology and topoisomerases

(2009) Joseph E. Deweese et al.   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

(2009) Ivan Laponogov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of magnesium and related divalent metal ions in topoisomerase structure and function

(2009) C. Sissi et al.   NUCLEIC ACIDS RESEARCH

Substituents on Etoposide That Interact with Human Topoisomerase IIα in the Binary Enzyme−Drug Complex: Contributions to Etoposide Binding and Activity†

(2008) Ryan P. Bender et al.   BIOCHEMISTRY

F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System

(2008) J.-M. Barret et al.   CANCER RESEARCH

Human topoisomerase II  uses a two-metal-ion mechanism for DNA cleavage

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH

The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing

(2008) J. E. Deweese et al.   NUCLEIC ACIDS RESEARCH