Article
Food Science & Technology
Shixiang Wu, Xingping Zhang, Wang Chen, Guohao Zhang, Qian Zhang, Hualin Yang, Yu Zhou
Summary: Inspired by the strong binding capacity of pyrophosphate (ppi) and copper ion (Cu2+), a ratiometric fluorescence immunoassay triggered by alkaline phosphatase (ALP) was developed for the detection of zearalenone (ZEN). This method exhibited high accuracy and reliability, with a limit of detection (LOD) of 0.014 ng/mL and a linear detection range of 3.51-17.78 ng/mL. It provides a new approach for efficient and accurate detection of ZEN.
Article
Chemistry, Analytical
Yu-An Feng, Hai Xu, Yang Zhou, Bao-Jun Wang, Jian Xiao, Ya-Wen Wang, Yu Peng
Summary: The newly designed NIR fluorescent probe SWJT-3 is capable of ratiometric determination of alkaline phosphatase (ALP) and can be used for both in vitro and in vivo detection. It is the first NIR and ratiometric fluorescent probe for imaging ALP in mice, with a large Stokes shift and low detection limit.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Jialin Wen, Yuxuan Hu, Na Li, Dan Li, Guangfan Zheng, Yongjian Zou, Minmin Zhang, Lingling Shui
Summary: In this study, a novel ratiometric fluorescent probe based on in situ fluorogenic reaction was developed for alkaline phosphatase (ALP) activity sensing. The probe showed high sensitivity for ALP activity with a detection limit of 0.08 U/L.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
An-Min Song, Yuan-Jun Tong, Ru-Ping Liang, Jian-Ding Qiu
Summary: The novel ThT@luminol-Eu-GMP CPNPs were synthesized for sensitive detection of ALP and arsenate, with boosted fluorescent performance of ThT achieved through a dual-path design involving molecular rotation restriction and FRET effect.
MICROCHEMICAL JOURNAL
(2021)
Article
Spectroscopy
Yu Ling, Lin Zhao He, Chu Chu Wan, Lei Han, Xiao Hu Wang, Zi Yi Xu, Xiao Lin Li, Nian Bing Li, Hong Qun Luo
Summary: The study demonstrated the potential of using ZIF-8 and lanthanide ions self-assembled into nanocomplexes as ratiometric fluorescent probes for monitoring ALP activity. The sensing system showed good performance in detecting ALP in human serum samples and inhibitor investigations. This work provides a new perspective for the manufacturing of simple and sensitive sensors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Huifang Wu, Shiying Ju, Yuwei Ling, Haozhe Sun, Yanfeng Tang, Changlun Tong
Summary: This study successfully synthesized four gelatinous Ln(3+) coordination polymers by self-assembly of ciprofloxacin, adenosine monophosphate, and Ln(3+) ions in water medium. It was found that the characteristic fluorescence of Ln(3+) significantly increased and the concentration of ciprofloxacin decreased with the increasing concentration of Ln-CPs, which was attributed to the aggregation-enhanced antenna effect due to the large aggregates formed by self-assembly.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Spectroscopy
Xiaoqian Huang, Xiangzhu Chen, Shijun Chen, Xueyan Zhang, Lin Wang, Shicong Hou, Xiaodong Ma
Summary: A novel ratiometric fluorescent probe has been developed for the detection of alkaline phosphatase (ALP) and fluorescence imaging in living cells, showing high accuracy and sensitivity. The probe exhibits a significant fluorescence color change from blue to green in response to ALP, with a detection limit as low as 0.16 U L-1. Additionally, the probe demonstrates excellent biocompatibility for application in biological systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Li Xiong, Long Yu, Shuo Li, Lixiang Feng, Yuxiu Xiao
Summary: A turn-on/off ratiometric fluorescence detection platform using multifunctional Ln-MOF and an enzymatic cascade reaction has been proposed for alkaline phosphatase (ALP) activity assay. The method showed good linear relationship and low detection limit, with successful application in human serum samples for monitoring ALP activity.
Article
Spectroscopy
Jingrui Cao, Qiong Wu, Xin Chang, Hongyu Chu, Hong Zhang, Xuedong Fang, Fangfang Chen
Summary: In this study, a small organic molecule-based ratiometric fluorescent probe was designed to effectively and sensitively detect the activity changes of alkaline phosphatase. The probe showed high selectivity and sensitivity under experimental conditions, and the measurement results in human serum samples matched well with those obtained using commercial kits. Additionally, the probe was successfully applied to image alkaline phosphatase in living hepatocytes with good selectivity and sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Xiaofei Li, Jing Lu, Zutian Li, Haoyuan Yang, Weiming Li, Yanju Liu, Mingsan Miao
Summary: An electrochemical method for detecting ALP activity through ARGET ATRP was developed in this study, showing good analytical performance and promising applications.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Analytical
Luxuan Yao, Shan He, Yiyu Chen, Huiting Lian, Bin Liu, Chengcai Lai, Xiaofeng Wei
Summary: Abnormal expression of alkaline phosphatase (ALP) in serum is important for health monitoring and disease diagnosis. A ratiometric approach using a carbon dot/cobalt-metal organic framework nanocoral mediated fluorescence-scattering sensor has been developed for simple and highly sensitive detection of ALP. The sensor effectively converted ALP into a ratio signal of fluorescence-scattering dual emission with a wide linear range of detection and improved sensitivity in serum.
Article
Chemistry, Applied
Shi-Qi Lin, Bao-Zhu Jia, Wei Luo, Hong Wang, Hong-Tao Lei, Wen-Feng Zhang, Zhen-Lin Xu, Lin Luo
Summary: In this study, an ultrasensitive ratiometric fluorescence (RF) sensing system based on the controllable formation of luminescent polydopamine and efficient quenching of carbon dots was proposed for the detection of alkaline phosphatase (ALP) activity. It achieved quantitative detection in the range of 0.01-100 mU/L and was integrated with an ALP-based ELISA platform to construct an RF-ELISA for the ultrasensitive detection of benzocaine in edible fish. This study not only provides an efficient method for ultratrace detection of ALP and benzocaine, but also proposes a universal platform for ultrasensitive detection of diverse targets in food analysis.
Article
Spectroscopy
Peihua Li, Na Liang, Chao Liu, Lian Xia, Fengli Qu, Zhi-Ling Song, Rong-Mei Kong
Summary: In this study, a novel silver ion-regulated ratiometric fluorescence method was developed for the determination of alkaline phosphatase (ALP). The method was based on carbon dots and o-phenylenediamine, and demonstrated enhanced sensitivity and efficiency in detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Cuiling Shang, Yansong Li, Qi Zhang, Song Tang, Xiaoqian Tang, Honglin Ren, Pan Hu, Shiying Lu, Peiwu Li, Yu Zhou
Summary: A dual-signal immunoassay utilizing alkaline phosphatase was developed to detect Zearalenone (ZEN) in cornmeal. The method combines colorimetric and electrochemical detection, generating Prussian blue nanoparticles and multicolor changes. The results demonstrate a high sensitivity for ZEN detection in corn samples through UV-vis spectrometry and differential pulse voltammetry.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Yuanjin Zhan, Shuangting Yang, Lifen Chen, Yanbo Zeng, Lei Li, Zhenyu Lin, Longhua Guo, Wei Xu
Summary: A ratiometric fluorescence sensor based on FRET strategy was developed for detecting ALP activity and its inhibitor Na3VO4. The sensor showed high FRET efficiency, ratiometric change in fluorescence intensity, and dual-emission self-correction ability, enabling quantitative detection and visual analysis of ALP activity. This biosensor provides a promising alternative for evaluating ALP-related diseases and can also be utilized for assessing Cu2+, PPi, and Na3VO4 levels, as well as screening ALP inhibitors.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Organic
Sean Goggins, Ellen A. Apsey, Mary F. Mahon, Christopher G. Frost
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Organic
Sam A. Spring, Sean Goggins, Christopher G. Frost
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Sean Goggins, Oliver P. Stark, Christophe Naz, Barrie J. Marsh, Christopher G. Frost
SUPRAMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Physical
Jamie A. Leitch, Yunas Bhonoah, Christopher G. Frost
Article
Computer Science, Information Systems
Joshua Introne, Ingrid Erickson, Bryan Semaan, Sean Goggins
JOURNAL OF THE ASSOCIATION FOR INFORMATION SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
James A. R. Tilden, Anneke T. Lubben, Shaun B. Reeksting, Gabriele Kociok-Kohn, Christopher G. Frost
Summary: Selective bioconjugation remains a significant challenge for synthetic chemists due to the high degree of functionality and stringent reaction conditions of biomolecules. This study reports the preparation of Pd(II) complexes for cysteine bioconjugation via a facile C-H activation process. These complexes demonstrate competitive bioconjugation efficiency and are synthesized using user-friendly methods and common Pd(II) sources, making them more cost-effective. Furthermore, these complexes do not require isolation and achieve high conversion efficiency and selectivity of a model peptide. They also show the ability to selectively arylate a single surface cysteine residue on a model protein substrate, further highlighting their utility.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Organic
Sam A. Spring, Sean Goggins, Christopher G. Frost
Summary: A dual pseudo-enantiomer system was developed, where two asymmetric catalytic cycles could be selectively triggered to afford an enantioenriched product. The system showed high enantioselectivity in the reduction of prochiral ketone following external stimulation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Proceedings Paper
Computer Science, Theory & Methods
Kevin Lumbard, Anna Buhman, Gabrielle Wethor, Matthew Hale, Sean Goggins, Matt Germonprez
AMCIS 2020 PROCEEDINGS
(2020)
Article
Education & Educational Research
Marcela Borge, Yann Shiou Ong, Sean Goggins
ETR&D-EDUCATIONAL TECHNOLOGY RESEARCH AND DEVELOPMENT
(2020)
Article
Psychology, Multidisciplinary
Joshua Introne, Sean Goggins
COMPUTERS IN HUMAN BEHAVIOR
(2019)
Article
Chemistry, Analytical
Sam A. Spring, Sean Goggins, Christopher G. Frost
Proceedings Paper
Computer Science, Interdisciplinary Applications
James M. Laffey, Joe Griffin, Justin Sigoloff, Sean Lander, Troy Sadler, Sean Goggins, So Mi Kim, Eric Wulff, Andrew J. Womack
PROCEEDINGS OF THE 12TH INTERNATIONAL CONFERENCE ON THE FOUNDATIONS OF DIGITAL GAMES (FDG'17)
(2017)
Article
Computer Science, Information Systems
Georg J. P. Link, Kevin Lumbard, Kieran Conboy, Michael Feldman, Joseph Feller, Jordana George, Matt Germonprez, Sean Goggins, Debora Jeske, Gaye Kiely, Kristen Schuster, Matt Willis
COMMUNICATIONS OF THE ASSOCIATION FOR INFORMATION SYSTEMS
(2017)
Proceedings Paper
Computer Science, Information Systems
Sean Goggins, Libby Hemphill, Matt Germonprez, A. J. Million, Aaron Halfaker
CSCW'17: COMPANION OF THE 2017 ACM CONFERENCE ON COMPUTER SUPPORTED COOPERATIVE WORK AND SOCIAL COMPUTING
(2017)
Article
Psychology, Multidisciplinary
Wanli Xing, Sean Goggins, Josh Introne
COMPUTERS IN HUMAN BEHAVIOR
(2018)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
