Article
Pharmacology & Pharmacy
Prachi Umbarkar, Anand P. Singh, Sultan Tousif, Qinkun Zhang, Palaniappan Sethu, Hind Lal
Summary: Nintedanib (NTB) is an FDA-approved tyrosine kinase inhibitor for pulmonary fibrosis, and study shows its potential in reducing cardiac fibrosis and improving cardiac function in a murine heart failure model, suggesting its promising application in treating HF patients.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Xiaonan Sun, Jalen Alford, Hongyu Qiu
Summary: Mitochondrial remodeling is crucial for maintaining normal cellular function and dysregulation can lead to complex diseases. Understanding the molecular basis and regulatory network of mitochondrial remodeling is important for elucidating the pathogenesis of cardiac diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Danilo Martins, Leonardo Rufino Garcia, Diego Aparecido Rios Queiroz, Taline Lazzarin, Carolina Rodrigues Tonon, Paola da Silva Balin, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, Leonardo Zornoff
Summary: Cardiac remodeling refers to a series of molecular, cellular, and interstitial changes in the heart that occur after different stimuli, manifesting clinically as changes in size, mass, geometry, and function. Remodeling plays a crucial pathophysiological role in the onset and progression of ventricular dysfunction. The role of oxidative stress as a therapeutic target for cardiac remodeling has been gaining attention in recent years.
Article
Cardiac & Cardiovascular Systems
Hongmei Zhao, Hongqin Yang, Chi Geng, Yang Chen, Junling Pang, Ting Shu, Meijun Zhao, Yaqin Tang, Zhiwei Li, Baicun Li, Cuiliu Hou, Xiaomin Song, Aoxue Wu, Xiaoxiao Guo, Si Chen, Bin Liu, Chen Yan, Jing Wang
Summary: The study found that IgE plays a causative role in pathological cardiac remodeling, at least partially through activating IgE-Fc epsilon R1 signaling in cardiomyocytes and cardiac fibroblasts. Therapeutic strategies targeting the IgE-Fc epsilon R1 axis may be effective for managing IgE-mediated cardiac remodeling.
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Mand Khidir, Xavier Galloo, Kensuke Hirasawa, Juhani Knuuti, Nina Ajmone Marsan, Victoria Delgado, Pieter van der Bijl, Jeroen J. Bax
Summary: This study investigated the prognostic value of cardiac remodeling in cardiac resynchronization therapy (CRT) candidates. The findings suggest that most candidates already have extensive cardiac remodeling at the time of referral, indicating the importance of early detection and referral for CRT implantation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Qing Yu, Peinan Ju, Wenxin Kou, Ming Zhai, Yanxi Zeng, Nuerbiyemu Maimaitiaili, Yefei Shi, Xu Xu, Yifan Zhao, Weixia Jian, Mark W. Feinberg, Yawei Xu, Jianhui Zhuang, Wenhui Peng
Summary: Macrophages play a crucial role in regulating inflammation and tissue repair, particularly in the development of heart failure. The presence of NLRC5 in circulating monocytes and cardiac macrophages was significantly increased in patients with hypertrophic cardiomyopathy. Deletion of NLRC5 in myeloid cells worsened pathological cardiac remodeling and inflammation induced by pressure overload. Mechanistically, NLRC5 interacted with HSPA8 and suppressed the NF-kB pathway in macrophages. The absence of NLRC5 in macrophages led to increased secretion of cytokines like interleukin-6 (IL-6), which had effects on cardiomyocyte hypertrophy and cardiac fibroblast activation. Tocilizumab, an anti-IL-6 receptor antagonist, could be a potential therapeutic strategy for cardiac remodeling and chronic heart failure.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
William W. Du, Jindong Xu, Weining Yang, Nan Wu, Feiya Li, Le Zhou, Sheng Wang, Xiangmin Li, Alina T. He, Kevin Y. Du, Kaixuan Zeng, Jian Ma, Juanjuan Lyu, Chao Zhang, Chi Zhou, Katarina Maksimovic, Burton B. Yang
Summary: The upregulation of circNlgn in patients with cardiac disease leads to cardiac overload. The novel peptide Nlgn173 binds to nuclear structural proteins and regulators, ultimately contributing to cardiac fibrosis and heart disease. Therapeutic implications may be derived from understanding this dysregulation mechanism.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Summary: The study highlights the inhibitory effects of Apilimod on cardiac fibrotic remodeling, controlling the TGF beta signaling pathway to prevent adverse remodeling. It also suggests a novel function for PIKfyve in regulating myocardial fibrosis and TGF beta pathway.
Review
Biochemistry & Molecular Biology
James N. Tsoporis, Ioannis-Alexandros Drosatos, Sahil Gupta, Hajera Amatullah, Shehla Izhar, Claudia C. dos Santos, Vasileos Salpeas, Angelos G. Rigopoulos, Ioannis K. Toumpoulis, Andreas S. Triantafyllis, Eleftharios Sakadakis, Nikolaos Kavantzas, John C. Marshall, Ioannis K. Rizos, Thomas G. Parker
Summary: Originally identified as an oncogene product, DJ-1 was later associated with a recessive form of Parkinson's disease. It plays a role outside the central nervous system and has been recognized for its involvement in the pathophysiology of cardiovascular disease. The review highlights DJ-1's potential as a novel therapeutic target for cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Lisa E. Dorn, William Lawrence, Jennifer M. Petrosino, Xianyao Xu, Thomas J. Hund, Bryan A. Whitson, Matthew S. Stratton, Paul M. L. Janssen, Peter J. Mohler, Anders Schlosser, Grith L. Sorensen, Federica Accornero
Summary: This study identified a novel role for nonmyocyte-derived MFAP4 in cardiac remodeling, playing a crucial role in cardiac adaptation to stress. Lack of MFAP4 resulted in increased cardiac hypertrophy, worsened cardiac function, and dysregulated G protein-coupled receptor and integrin signaling in the heart.
CIRCULATION RESEARCH
(2021)
Review
Medicine, General & Internal
Frans A. van Nieuwenhoven, Blanche Schroen, Lucio Barile, Lars van Middendorp, Frits W. Prinzen, Angelo Auricchio
Summary: Cardiac resynchronization therapy (CRT) is a valuable addition to heart failure treatment options, especially for patients with electrical conduction disturbances causing regional contraction patterns (dyssynchrony). Experimental studies have shown extensive molecular and cellular remodeling in dyssynchronous hearts. Increasing evidence suggests that several miRNAs are involved in this remodeling process. Measurement of myocardium-derived miRNAs in extracellular vesicles (EVs) in peripheral blood may provide new insights into investigating and monitoring (reverse) remodeling in dyssynchronous and resynchronized hearts of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Critical Care Medicine
Yutian Li, Qianqian Li, Guo-Chang Fan
Summary: Macrophages are crucial for cardiac development, homeostasis, and healing, playing a vital role in clearing dying cells and cellular debris through efferocytosis. Understanding macrophage efferocytosis provides valuable insights on cardiac health and offers new therapeutic strategies for patients with heart failure.
Article
Cardiac & Cardiovascular Systems
Zhongkai Wang, Pan Li, Bili Zhang, Jingjuan Huang, Shaoping Chen, Zhuhong Cai, Yingyi Qin, Jihai Fan, Wendong Tang, Yongwen Qin, Ruogu Li, Xianxian Zhao
Summary: The combination of SyncAV with BiV leads to a more significant reduction in QRS duration and improves LV remodeling in HF patients undergoing CRT therapy, compared to conventional BiV pacing. During follow-up, no deaths related to HF deterioration or severe procedure complications occurred.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Hitoshi Nakagawa, Takuya Kumazawa, Kenji Onoue, Yasuki Nakada, Tomoya Nakano, Satomi Ishihara, Naoto Minamino, Hiroshi Hosoda, Nobuhisa Iwata, Tomoya Ueda, Ayako Seno, Taku Nishida, Tsunenari Soeda, Satoshi Okayama, Makoto Watanabe, Rika Kawakami, Yoshihiko Saito
Summary: The study showed that overexpression of NEP in cardiomyocytes leads to increased degradation of natriuretic peptides in the heart, resulting in an exaggerated hypertrophic and fibrotic response to pressure overload.
