Pyruvate kinase is post-translationally regulated by sirtuin 2 in Aedes aegypti mosquitoes

Reverse electron transfer is activated during aging and contributes to aging and age‐related disease

(2023) Suman Rimal et al.   EMBO REPORTS

Human sirtuin 2 inhibitors, their mechanisms and binding modes

(2023) André Berndt Penteado et al.   Future Medicinal Chemistry

In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents

(2023) Mahmoud A. A. Ibrahim et al.   Scientific Reports

Ornithine decarboxylase deficiency critically impairs nitrogen metabolism and survival in Aedes aegypti mosquitoes

(2022) Jun Isoe et al.   FASEB JOURNAL

SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells

(2021) Li Xia et al.   Cell Death & Disease

Unraveling mosquito metabolism with mass spectrometry-based metabolomics

(2021) Thomas D. Horvath et al.   TRENDS IN PARASITOLOGY

Sirtuin Modulators in Cellular and Animal Models of Human Diseases

(2021) Jun Young Hong et al.   Frontiers in Pharmacology

Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically

(2020) Handi Dahmana et al.   Pathogens

Mass spectrometry-based stable-isotope tracing uncovers metabolic alterations in pyruvate kinase-deficient Aedes aegypti mosquitoes

(2020) Natthida Petchampai et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Molecular Perspective on Sirtuin Activity

(2020) Carla S. S. Teixeira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deacetylation of metabolic enzymes by Sirt2 modulates pyruvate homeostasis to extend insect lifespan

(2018) Tao Wang et al.   Aging-US

Positional stable isotope tracer analysis reveals carbon routes during ammonia metabolism of Aedes aegypti mosquitoes

(2018) Thomas D. Horvath et al.   FASEB JOURNAL

Sirt4 is a mitochondrial regulator of metabolism and lifespan inDrosophila melanogaster

(2018) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinctive regulatory properties of pyruvate kinase 1 from Aedes aegypti mosquitoes

(2018) Natthida Petchampai et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Xanthine dehydrogenase-1 silencing in Aedes aegypti mosquitoes promotes a blood feeding–induced adulticidal activity

(2017) Jun Isoe et al.   FASEB JOURNAL

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

(2017) Kathleen A. Hershberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis

(2017) Young Cha et al.   NATURE CELL BIOLOGY

Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2

(2017) Mingming Zhang et al.   Scientific Reports

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

(2016) Seong-Hoon Park et al.   CANCER RESEARCH

Effective disposal of nitrogen waste in blood-fed Aedes aegypti mosquitoes requires alanine aminotransferase

(2016) Stacy Mazzalupo et al.   FASEB JOURNAL

Who watches the watchmen? Regulation of the expression and activity of sirtuins

(2016) Marcin Buler et al.   FASEB JOURNAL

Regulation of pyruvate kinase isozyme M2 is mediated by the ubiquitin-specific protease 20

(2015) SO-RA KIM et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

(2015) Yan-Bin Teng et al.   Scientific Reports

Oxidative Stress Activates SIRT2 to Deacetylate and Stimulate Phosphoglycerate Mutase

(2014) Y. Xu et al.   CANCER RESEARCH

DrosophilaSirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity

(2014) Motiur Rahman et al.   JOURNAL OF CELL BIOLOGY

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

The ‘ubiquitous’ reality of vector immunology

(2013) Maiara S. Severo et al.   CELLULAR MICROBIOLOGY

Urea Synthesis and Excretion in Aedes aegypti Mosquitoes Are Regulated by a Unique Cross-Talk Mechanism

(2013) Jun Isoe et al.   PLoS One

Decoding the Ubiquitin-Mediated Pathway of Arthropod Disease Vectors

(2013) Anthony Choy et al.   PLoS One

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

(2011) David M. Taylor et al.   ACS Chemical Biology

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

Acetylation Regulates Gluconeogenesis by Promoting PEPCK1 Degradation via Recruiting the UBR5 Ubiquitin Ligase

(2011) Wenqing Jiang et al.   MOLECULAR CELL

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Differential ammonia metabolism in Aedes aegypti fat body and midgut tissues

(2010) Patricia Y. Scaraffia et al.   JOURNAL OF INSECT PHYSIOLOGY

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

(2009) Sebastian Greiss et al.   MOLECULES AND CELLS

The genome of the model beetle and pest Tribolium castaneum

(2008) Stephen Richards et al.   NATURE

Discovery of an alternate metabolic pathway for urea synthesis in adult Aedes aegypti mosquitoes

(2008) P. Y. Scaraffia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA