Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies

Bovine Lactoferrin Inhibits the Efficiency of Invasion of Respiratory A549 Cells of Different Iron-Regulated Morphological Forms of Pseudomonas Aeruginosa and Burkholderia Cenocepacia

(2017) F. Berlutti et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

(2016) Elizabeth L. Salsgiver et al.   CHEST

Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy

(2015) Audrey L. Lamb   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Spoils of war: iron at the crux of clinical and ecological fitness of Pseudomonas aeruginosa

(2015) Angela T. Nguyen et al.   BIOMETALS

Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia

(2015) J. Tyrrell et al.   BIOMETALS

Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship

(2015) M. Noni et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Future trends in cystic fibrosis demography in 34 European countries

(2015) Pierre-Régis Burgel et al.   EUROPEAN RESPIRATORY JOURNAL

Coculture of Staphylococcus aureus with Pseudomonas aeruginosa Drives S. aureus towards Fermentative Metabolism and Reduced Viability in a Cystic Fibrosis Model

(2015) Laura M. Filkins et al.   JOURNAL OF BACTERIOLOGY

Rapid Detection of Emerging Pathogens and Loss of Microbial Diversity Associated with Severe Lung Disease in Cystic Fibrosis

(2015) William G. Flight et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Molecular epidemiology of Aspergillus collected from cystic fibrosis patients

(2015) Raquel Sabino et al.   Journal of Cystic Fibrosis

Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis

(2015) Michael D. Parkins et al.   Journal of Cystic Fibrosis

Protection of mice against Staphylococcus aureus infection by a recombinant protein ClfA–IsdB–Hlg as a vaccine candidate

(2015) Somayeh Delfani et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Involvement of reductases IruO and NtrA in iron acquisition byStaphylococcus aureus

(2015) Mélissa Hannauer et al.   MOLECULAR MICROBIOLOGY

Cystic fibrosis lung microbiome: Opportunities to reconsider management of airway infection

(2015) Lindsay J. Caverly et al.   PEDIATRIC PULMONOLOGY

Association of chronicCandida albicansrespiratory infection with a more severe lung disease in patients with cystic fibrosis

(2015) Alex Gileles-Hillel et al.   PEDIATRIC PULMONOLOGY

Long-term social dynamics drive loss of function in pathogenic bacteria

(2015) Sandra Breum Andersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa manipulates redox and iron homeostasis of its microbiota partner Aspergillus fumigatus via phenazines

(2015) Benoit Briard et al.   Scientific Reports

The daily dynamics of cystic fibrosis airway microbiota during clinical stability and at exacerbation

(2015) Lisa A Carmody et al.   Microbiome

Changes in Cystic Fibrosis Airway Microbial Community Associated with a Severe Decline in Lung Function

(2015) Patrizia Paganin et al.   PLoS One

Inhibition of Aspergillus fumigatus and Its Biofilm by Pseudomonas aeruginosa Is Dependent on the Source, Phenotype and Growth Conditions of the Bacterium

(2015) Jose A. G. Ferreira et al.   PLoS One

Lung microbiota across age and disease stage in cystic fibrosis

(2015) Bryan Coburn et al.   Scientific Reports

Biosynthesis of Novel Pyoverdines by Domain Substitution in a Nonribosomal Peptide Synthetase of Pseudomonas aeruginosa

(2014) Mark J. Calcott et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synthesis and antibacterial activity of catecholate–ciprofloxacin conjugates

(2014) Sylvain Fardeau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genetic manipulation of non-ribosomal peptide synthetases to generate novel bioactive peptide products

(2014) Mark J. Calcott et al.   BIOTECHNOLOGY LETTERS

Chemistry and Biology of Pyoverdines, Pseudomonas Primary Siderophores

(2014) C. Cezard et al.   CURRENT MEDICINAL CHEMISTRY

Csa2, a member of the Rbt5 protein family, is involved in the utilization of iron from human hemoglobin duringCandida albicanshyphal growth

(2014) Kazuko Okamoto-Shibayama et al.   FEMS YEAST RESEARCH

In vitro activity of the siderophore monosulfactam BAL30072 against contemporary Gram-negative pathogens from New York City, including multidrug-resistant isolates

(2014) David Landman et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Combination of hypothiocyanite and lactoferrin (ALX-109) enhances the ability of tobramycin and aztreonam to eliminate Pseudomonas aeruginosa biofilms growing on cystic fibrosis airway epithelial cells

(2014) S. Moreau-Marquis et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Influence of Iron and Aeration on Staphylococcus aureus Growth, Metabolism, and Transcription

(2014) N. Ledala et al.   JOURNAL OF BACTERIOLOGY

Adaptation of Iron Homeostasis Pathways by a Pseudomonas aeruginosa Pyoverdine Mutant in the Cystic Fibrosis Lung

(2014) A. T. Nguyen et al.   JOURNAL OF BACTERIOLOGY

Baulamycins A and B, Broad-Spectrum Antibiotics Identified as Inhibitors of Siderophore Biosynthesis in Staphylococcus aureus and Bacillus anthracis

(2014) Ashootosh Tripathi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa

(2014) Gaëtan L. A. Mislin et al.   Metallomics

Siderophore–drug complexes: potential medicinal applications of the ‘Trojan horse’ strategy

(2014) Agnieszka Górska et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Within-Host Evolution of Pseudomonas aeruginosa Reveals Adaptation toward Iron Acquisition from Hemoglobin

(2014) R. L. Marvig et al.   mBio

Iron-Regulated Expression of Alginate Production, Mucoid Phenotype, and Biofilm Formation by Pseudomonas aeruginosa

(2014) J. R. Wiens et al.   mBio

A Relay Network of Extracellular Heme-Binding Proteins Drives C. albicans Iron Acquisition from Hemoglobin

(2014) Galit Kuznets et al.   PLoS Pathogens

Candida albicans Ethanol Stimulates Pseudomonas aeruginosa WspR-Controlled Biofilm Formation as Part of a Cyclic Relationship Involving Phenazines

(2014) Annie I. Chen et al.   PLoS Pathogens

Siderophores as “Trojan Horses”: tackling multidrug resistance?

(2014) Carla C. C. R. de Carvalho et al.   Frontiers in Microbiology

Adaptation-Based Resistance to Siderophore-Conjugated Antibacterial Agents by Pseudomonas aeruginosa

(2013) Andrew P. Tomaras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The crucial role of iron uptake in Aspergillus fumigatus virulence

(2013) Margo M Moore   CURRENT OPINION IN MICROBIOLOGY

The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence

(2013) Yakir Vaknin et al.   FUNGAL GENETICS AND BIOLOGY

Sequestration and Scavenging of Iron in Infection

(2013) Nermi L. Parrow et al.   INFECTION AND IMMUNITY

Pseudomonas aeruginosa Uses Multiple Pathways To Acquire Iron during Chronic Infection in Cystic Fibrosis Lungs

(2013) Anna F. Konings et al.   INFECTION AND IMMUNITY

Effect of an Investigational Vaccine for Preventing Staphylococcus aureus Infections After Cardiothoracic Surgery

(2013) Vance G. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli

(2013) B. Hofer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Ferritin and ferrihydrite nanoparticles as iron sources for Pseudomonas aeruginosa

(2013) Carolyn Dehner et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of P. aeruginosa

(2013) Kellie Hom et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Nonribosomal Peptide Synthetase-Derived Iron(III) Complex from the Pathogenic Fungus Aspergillus fumigatus

(2013) Wen-Bing Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Growth on mannitol-rich media elicits a genome-wide transcriptional response in Burkholderia multivorans that impacts on multiple virulence traits in an exopolysaccharide-independent manner

(2013) C. C. Denman et al.   MICROBIOLOGY-SGM

Pore-forming pyocin S5 utilizes the FptA ferripyochelin receptor to kill Pseudomonas aeruginosa

(2013) A. Elfarash et al.   MICROBIOLOGY-SGM

A novel siderophore-independent strategy of iron uptake in the genusBurkholderia

(2013) Anugraha Mathew et al.   MOLECULAR MICROBIOLOGY

Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity

(2013) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switching between apparently redundant iron-uptake mechanisms benefits bacteria in changeable environments

(2013) Z. Dumas et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Control of Candida albicans Metabolism and Biofilm Formation by Pseudomonas aeruginosa Phenazines

(2013) D. K. Morales et al.   mBio

Ferrous Iron Is a Significant Component of Bioavailable Iron in Cystic Fibrosis Airways

(2013) R. C. Hunter et al.   mBio

Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans

(2013) Mélissa Caza et al.   Frontiers in Cellular and Infection Microbiology

Pseudomonas aeruginosa adapts its iron uptake strategies in function of the type of infections

(2013) Pierre Cornelis et al.   Frontiers in Cellular and Infection Microbiology

Biosynthesis of Albomycin δ2 Provides a Template for Assembling Siderophore and Aminoacyl-tRNA Synthetase Inhibitor Conjugates

(2012) Yu Zeng et al.   ACS Chemical Biology

Structural and functional characterization of theStaphylococcus aureusvirulence factor and vaccine candidate FhuD2

(2012) Paolo Mariotti et al.   BIOCHEMICAL JOURNAL

Cystic fibrosis: Insight into CFTR pathophysiology and pharmacotherapy

(2012) Bob Lubamba et al.   CLINICAL BIOCHEMISTRY

Iron Homeostasis during Cystic Fibrosis Pulmonary Exacerbation

(2012) Alex H. Gifford et al.   CTS-Clinical and Translational Science

Preclinical evaluation of two 68Ga-siderophores as potential radiopharmaceuticals for Aspergillus fumigatus infection imaging

(2012) Milos Petrik et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients

(2012) Andrew J. Ghio et al.   Journal of Cystic Fibrosis

Staphylococcus aureus FhuD2 Is Involved in the Early Phase of Staphylococcal Dissemination and Generates Protective Immunity in Mice

(2012) Ravi P. N. Mishra et al.   JOURNAL OF INFECTIOUS DISEASES

Iron and pH-responsive FtrABCD ferrous iron utilization system ofBordetellaspecies

(2012) Timothy J. Brickman et al.   MOLECULAR MICROBIOLOGY

Involvement of Iron in Biofilm Formation by Staphylococcus aureus

(2012) Mei-Hui Lin et al.   PLoS One

Interkingdom metabolic transformations captured by microbial imaging mass spectrometry

(2012) W. J. Moree et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron – A Key Nexus in the Virulence of Aspergillus fumigatus

(2012) Hubertus Haas   Frontiers in Microbiology

Combination Therapy of Murine Mucormycosis or Aspergillosis with Iron Chelation, Polyenes, and Echinocandins

(2011) Ashraf S. Ibrahim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pseudomonas siderophores in the sputum of patients with cystic fibrosis

(2011) Lois W. Martin et al.   BIOMETALS

The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation

(2011) Michael Blatzer et al.   FUNGAL GENETICS AND BIOLOGY

Staphylococcus aureus Transporters Hts, Sir, and Sst Capture Iron Liberated from Human Transferrin by Staphyloferrin A, Staphyloferrin B, and Catecholamine Stress Hormones, Respectively, and Contribute to Virulence

(2011) Federico C. Beasley et al.   INFECTION AND IMMUNITY

Phenazine-1-Carboxylic Acid Promotes Bacterial Biofilm Development via Ferrous Iron Acquisition

(2011) Y. Wang et al.   JOURNAL OF BACTERIOLOGY

A battle for iron: host sequestration and Staphylococcus aureus acquisition

(2011) Kathryn P. Haley et al.   MICROBES AND INFECTION

FvbA is required for vibriobactin utilization in Pseudomonas aeruginosa

(2011) S. Elias et al.   MICROBIOLOGY-SGM

Dual Organism Transcriptomics of Airway Epithelial Cells Interacting with Conidia of Aspergillus fumigatus

(2011) Jean L. Oosthuizen et al.   PLoS One

Molecular Mechanisms ofStaphylococcus aureusIron Acquisition

(2010) Neal D. Hammer et al.   Annual Review of Microbiology

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

(2010) M. G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Iron uptake and metabolism in pseudomonads

(2010) Pierre Cornelis   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bovine lactoferrin interacts with cable pili of Burkholderia cenocepacia

(2010) Maria Grazia Ammendolia et al.   BIOMETALS

Identification of a siderophore utilization locus in nontypeable Haemophilus influenzae

(2010) Daniel J Morton et al.   BMC MICROBIOLOGY

The Changing Microbial Epidemiology in Cystic Fibrosis

(2010) J. J. LiPuma   CLINICAL MICROBIOLOGY REVIEWS

The Ferrichrome Uptake Pathway in Pseudomonas aeruginosa Involves an Iron Release Mechanism with Acylation of the Siderophore and Recycling of the Modified Desferrichrome

(2010) M. Hannauer et al.   JOURNAL OF BACTERIOLOGY

Candidaspecies in cystic fibrosis: A road less travelled

(2010) Sanjay H. Chotirmall et al.   MEDICAL MYCOLOGY

The crucial role of the Aspergillus fumigatus siderophore system in interaction with alveolar macrophages

(2010) Markus Schrettl et al.   MICROBES AND INFECTION

The pobA gene of Burkholderia cenocepacia encodes a Group I Sfp-type phosphopantetheinyltransferase required for biosynthesis of the siderophores ornibactin and pyochelin

(2010) A. H. Asghar et al.   MICROBIOLOGY-SGM

Role of bacteriocins in mediating interactions of bacterial isolates taken from cystic fibrosis patients

(2010) S. Bakkal et al.   MICROBIOLOGY-SGM

Role of lung iron in determining the bacterial and host struggle in cystic fibrosis

(2009) D. W. Reid et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Tobramycin and FDA-Approved Iron Chelators EliminatePseudomonas aeruginosaBiofilms on Cystic Fibrosis Cells

(2009) Sophie Moreau-Marquis et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Ferricrocin, a Siderophore Involved in Intra- and Transcellular Iron Distribution in Aspergillus fumigatus

(2009) A. Wallner et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Siderophores as drug delivery agents: application of the “Trojan Horse” strategy

(2009) Ute Möllmann et al.   BIOMETALS

Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin “Trojan Horse” antibiotics and synthetic desferridanoxamine-antibiotic conjugates

(2009) Timothy A. Wencewicz et al.   BIOMETALS

Iron acquisition by Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis

(2009) Iain L. Lamont et al.   BIOMETALS

Sideromycins: tools and antibiotics

(2009) Volkmar Braun et al.   BIOMETALS

Genetic diversity of siderophore-producing bacteria of tobacco rhizosphere

(2009) Fang Tian et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Sputum Trace Metals Are Biomarkers of Inflammatory and Suppurative Lung Disease

(2009) Robert D. Gray et al.   CHEST

Candida albicans iron acquisition within the host

(2009) Ricardo S. Almeida et al.   FEMS YEAST RESEARCH

The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant

(2009) Daniel J. Morton et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

(2009) A. S. Ibrahim et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Elucidation of the Mechanism by Which Catecholamine Stress Hormones Liberate Iron from the Innate Immune Defense Proteins Transferrin and Lactoferrin

(2009) S. M. Sandrini et al.   JOURNAL OF BACTERIOLOGY

Structural biology of heme binding in the Staphylococcus aureus Isd system

(2009) Jason C. Grigg et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Characterization of staphyloferrin A biosynthetic and transport mutants inStaphylococcus aureus

(2009) Federico C. Beasley et al.   MOLECULAR MICROBIOLOGY

Molecular characterization of staphyloferrin B biosynthesis inStaphylococcus aureus

(2009) Johnson Cheung et al.   MOLECULAR MICROBIOLOGY

Recycling Iron in Normal and Pathological States

(2009) Carole Beaumont et al.   SEMINARS IN HEMATOLOGY

A survey of TonB-dependent receptors in fluorescent pseudomonads

(2009) Pierre Cornelis et al.   Environmental Microbiology Reports

The ΔF508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability

(2008) Sophie Moreau-Marquis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genomic, genetic and structural analysis of pyoverdine-mediated iron acquisition in the plant growth-promoting bacterium Pseudomonas fluorescens SBW25

(2008) Christina D Moon et al.   BMC MICROBIOLOGY

Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis

(2008) M. Seifert et al.   IMMUNOBIOLOGY

The Role of the Cytoplasmic Heme-binding Protein (PhuS) ofPseudomonas aeruginosain Intracellular Heme Trafficking and Iron Homeostasis

(2008) Ajinder P. Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microbial endocrinology: how stress influences susceptibility to infection

(2008) Primrose P.E. Freestone et al.   TRENDS IN MICROBIOLOGY

The Hyphal-Associated Adhesin and Invasin Als3 of Candida albicans Mediates Iron Acquisition from Host Ferritin

(2008) Ricardo S. Almeida et al.   PLoS Pathogens