Methane-Rich Saline Suppresses ER-Mitochondria Contact and Activation of the NLRP3 Inflammasome by Regulating the PERK Signaling Pathway to Ameliorate Intestinal Ischemia‒Reperfusion Injury

ER-mitochondria communication is involved in NLRP3 inflammasome activation under stress conditions in the innate immune system

(2022) Ana Catarina Pereira et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria

(2022) Arthur Bassot et al.   Cell Reports

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

(2020) Yifan Jia et al.   Redox Biology

Gut Ischemia Reperfusion Injury Induces Lung Inflammation via Mesenteric Lymph-Mediated Neutrophil Activation

(2020) Yonggang Ma et al.   Frontiers in Immunology

Methane alleviates sepsis-induced injury by inhibiting pyroptosis and apoptosis in vivo and in vitro experiments

(2019) Zeyu Li et al.   Aging-US

Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway

(2019) Zeyu Li et al.   Oxidative Medicine and Cellular Longevity

Methane Alleviates Acetaminophen-Induced Liver Injury by Inhibiting Inflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis through the Nrf2/HO-1/NQO1 Signaling Pathway

(2019) Yang Feng et al.   Oxidative Medicine and Cellular Longevity

Astragaloside IV attenuates sepsis-induced intestinal barrier dysfunction via suppressing RhoA/NLRP3 inflammasome signaling

(2019) Shuhua Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mitochondria-associated membranes (MAMs) and inflammation

(2018) Sonia Missiroli et al.   Cell Death & Disease

Repression of TXNIP-NLRP3 axis restores intestinal barrier function via inhibition of myeloperoxidase activity and oxidative stress in nonalcoholic steatohepatitis

(2018) Ru-Xue Bai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Methane-Rich Saline Ameliorates Sepsis-Induced Acute Kidney Injury through Anti-Inflammation, Antioxidative, and Antiapoptosis Effects by Regulating Endoplasmic Reticulum Stress

(2018) Yifan Jia et al.   Oxidative Medicine and Cellular Longevity

ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome

(2018) Claire Angebault et al.   Science Signaling

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

(2017) Zhirong Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

(2017) Shanshan Sun et al.   Redox Biology

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

(2015) Liara M. Gonzalez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

(2015) Chul-Su Yang et al.   Nature Communications

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)- mediated endoplasmic reticulum stress- induced apoptosis in diabetic cardiomyopathy

(2013) Zhong-Wei Liu et al.   Cardiovascular Diabetology

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

(2012) T Verfaillie et al.   CELL DEATH AND DIFFERENTIATION

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY