Functional Metagenomics as a Tool for Identification of New Antibiotic Resistance Genes from Natural Environments

A platform for the discovery of new macrolide antibiotics

(2016) Ian B. Seiple et al.   NATURE

Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast

(2016) Hahk-Soo Kang et al.   ACS Synthetic Biology

A new view of the tree of life

(2016) Laura A. Hug et al.   Nature Microbiology

Isolation of oxygenase genes for indigo-forming activity from an artificially polluted soil metagenome by functional screening using Pseudomonas putida strains as hosts

(2015) Hirofumi Nagayama et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Isolation and characterization of novel lipases/esterases from a bovine rumen metagenome

(2015) Florence Privé et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New dioxygenase from metagenomic library from Brazilian soil: insights into antibiotic resistance and bioremediation

(2015) Débora Farage Knupp dos Santos et al.   BIOTECHNOLOGY LETTERS

Accurate, multi-kb reads resolve complex populations and detect rare microorganisms

(2015) Itai Sharon et al.   GENOME RESEARCH

Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes

(2015) Bing Li et al.   ISME Journal

Identification of glycosyl hydrolases from a metagenomic library of microflora in sugarcane bagasse collection site and their cooperative action on cellulose degradation

(2015) Pattanop Kanokratana et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Est16, a New Esterase Isolated from a Metagenomic Library of a Microbial Consortium Specializing in Diesel Oil Degradation

(2015) Mariana Rangel Pereira et al.   PLoS One

A new alkaline lipase obtained from the metagenome of marine sponge Ircinia sp.

(2015) Jing Su et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Resistance integrons: class 1, 2 and 3 integrons

(2015) Yang Deng et al.   Annals of Clinical Microbiology and Antimicrobials

Inhibition of the growth ofBacillus subtilisDSM10 by a newly discovered antibacterial protein from the soil metagenome

(2015) Mark M O’Mahony et al.   Bioengineered

A Response Regulator from a Soil Metagenome Enhances Resistance to the β-Lactam Antibiotic Carbenicillin in Escherichia coli

(2015) Heather K. Allen et al.   PLoS One

Immobilization and Characterization of a New Regioselective and Enantioselective Lipase Obtained from a Metagenomic Library

(2015) Robson Carlos Alnoch et al.   PLoS One

Antibiotic Resistance Mechanisms Inform Discovery: Identification and Characterization of a Novel Amycolatopsis Strain Producing Ristocetin

(2014) Andrew W. Truman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Abundant rifampin resistance genes and significant correlations of antibiotic resistance genes and plasmids in various environments revealed by metagenomic analysis

(2014) Liping Ma et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An exceptionally cold-adapted alpha-amylase from a metagenomic library of a cold and alkaline environment

(2014) Jan Kjølhede Vester et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Large-Scale Metagenomic-Based Study of Antibiotic Resistance in the Environment

(2014) Joseph Nesme et al.   CURRENT BIOLOGY

Functional metagenomic characterization of antibiotic resistance genes in agricultural soils from China

(2014) Jian Qiang Su et al.   ENVIRONMENT INTERNATIONAL

Prevalence of Antibiotic Resistance Genes and Bacterial Pathogens in Long-Term Manured Greenhouse Soils As Revealed by Metagenomic Survey

(2014) Hua Fang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A Comprehensive Insight into Tetracycline Resistant Bacteria and Antibiotic Resistance Genes in Activated Sludge Using Next-Generation Sequencing

(2014) Kailong Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cloning and Characterization of a Novel ��-Amylase from a Fecal Microbial Metagenome

(2014) Bo Xu et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Integrons: Past, Present, and Future

(2014) Michael R. Gillings   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Bacterial phylogeny structures soil resistomes across habitats

(2014) Kevin J. Forsberg et al.   NATURE

Functional metagenomic analysis reveals rivers are a reservoir for diverse antibiotic resistance genes

(2014) G.C.A. Amos et al.   VETERINARY MICROBIOLOGY

Fate of antibiotic resistance genes in sewage treatment plant revealed by metagenomic approach

(2014) Ying Yang et al.   WATER RESEARCH

The Comprehensive Antibiotic Resistance Database

(2013) Andrew G. McArthur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring Variation of Antibiotic Resistance Genes in Activated Sludge over a Four-Year Period through a Metagenomic Approach

(2013) Ying Yang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Marine Sediment Bacteria Harbor Antibiotic Resistance Genes Highly Similar to Those Found in Human Pathogens

(2013) Jing Yang et al.   MICROBIAL ECOLOGY

Metagenomic Profiling of Antibiotic Resistance Genes and Mobile Genetic Elements in a Tannery Wastewater Treatment Plant

(2013) Zhu Wang et al.   PLoS One

Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems

(2013) Ken Vercammen et al.   MicrobiologyOpen

Wide Variation in Antibiotic Resistance Proteins Identified by Functional Metagenomic Screening of a Soil DNA Library

(2012) Kelly M. McGarvey et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of a novel fosfomycin-resistant UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from a soil metagenome

(2012) Gong Cheng et al.   BIOTECHNOLOGY LETTERS

Characterization and Quantitation of a Novel β-Lactamase Gene Found in a Wastewater Treatment Facility and the Surrounding Coastal Ecosystem

(2011) Miguel I. Uyaguari et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of novel antibiotic resistance genes identified by functional metagenomics on soil samples

(2011) Gloria Torres-Cortés et al.   ENVIRONMENTAL MICROBIOLOGY

Plasmid Metagenome Reveals High Levels of Antibiotic Resistance Genes and Mobile Genetic Elements in Activated Sludge

(2011) Tong Zhang et al.   PLoS One

Expanding Small-Molecule Functional Metagenomics through Parallel Screening of Broad-Host-Range Cosmid Environmental DNA Libraries in Diverse Proteobacteria

(2010) J. W. Craig et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification of Diverse Antimicrobial Resistance Determinants Carried on Bacterial, Plasmid, or Viral Metagenomes from an Activated Sludge Microbial Assemblage

(2010) L. C. Parsley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metagenomic Analysis of Apple Orchard Soil Reveals Antibiotic Resistance Genes Encoding Predicted Bifunctional Proteins

(2010) J. J. Donato et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Broad Dissemination of Plasmid-Mediated Quinolone Resistance Genes in Sediments of Two Urban Coastal Wetlands

(2010) David E. Cummings et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome

(2008) Chang-Muk Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil

(2008) Heather K Allen et al.   ISME Journal

ARDB--Antibiotic Resistance Genes Database

(2008) B. Liu et al.   NUCLEIC ACIDS RESEARCH

Antibiotics and Antibiotic Resistance Genes in Natural Environments

(2008) J. L. Martinez   SCIENCE