Identification of a metagenomic gene cluster containing a new class A beta-lactamase and toxin-antitoxin systems

Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins

(2012) Philipp Engel et al.   NATURE

The great screen anomaly—a new frontier in product discovery through functional metagenomics

(2011) David Matthias Ekkers et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Toxins-antitoxins: diversity, evolution and function

(2011) Finbarr Hayes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Characterization of novel antibiotic resistance genes identified by functional metagenomics on soil samples

(2011) Gloria Torres-Cortés et al.   ENVIRONMENTAL MICROBIOLOGY

Switch or Funnel: How RND-Type Transport Systems Control Periplasmic Metal Homeostasis

(2011) E.-H. Kim et al.   JOURNAL OF BACTERIOLOGY

Metal toxicity

(2011) Gregor Grass et al.   Metallomics

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Diversity of bacterial type II toxin–antitoxin systems: a comprehensive search and functional analysis of novel families

(2011) Raphaël Leplae et al.   NUCLEIC ACIDS RESEARCH

Antibiotic Resistance Gene Abundances Correlate with Metal and Geochemical Conditions in Archived Scottish Soils

(2011) Charles W. Knapp et al.   PLoS One

Plasmid Metagenome Reveals High Levels of Antibiotic Resistance Genes and Mobile Genetic Elements in Activated Sludge

(2011) Tong Zhang et al.   PLoS One

Functional Metagenomics Reveals Previously Unrecognized Diversity of Antibiotic Resistance Genes in Gulls

(2011) Adam C. Martiny et al.   Frontiers in Microbiology

Novel Florfenicol and Chloramphenicol Resistance Gene Discovered in Alaskan Soil by Using Functional Metagenomics

(2010) K. S. Lang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The structural mechanism of the inhibition of archaeal RelE toxin by its cognate RelB antitoxin

(2010) Masaaki Shinohara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

(2010) Michael A. Kohanski et al.   MOLECULAR CELL

Call of the wild: antibiotic resistance genes in natural environments

(2010) Heather K. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Antimicrobial resistance of heterotrophic bacteria in sewage-contaminated rivers

(2010) Tamara Garcia-Armisen et al.   WATER RESEARCH

Functional metagenomics for enzyme discovery: challenges to efficient screening

(2009) Taku Uchiyama et al.   CURRENT OPINION IN BIOTECHNOLOGY

Inhibitory Mechanism ofEscherichia coliRelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site

(2009) Guang-Yao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RelB and RelE of Escherichia coli Form a Tight Complex That Represses Transcription via the Ribbon–Helix–Helix Motif in RelB

(2009) Martin Overgaard et al.   JOURNAL OF MOLECULAR BIOLOGY

SeaView Version 4: A Multiplatform Graphical User Interface for Sequence Alignment and Phylogenetic Tree Building

(2009) M. Gouy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Conserved Water Molecules Stabilize the  -Loop in Class A  -Lactamases

(2008) F. Bos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotics and antibiotic resistance in water environments

(2008) Fernando Baquero et al.   CURRENT OPINION IN BIOTECHNOLOGY

Functional metagenomics reveals diverse β-lactamases in a remote Alaskan soil

(2008) Heather K Allen et al.   ISME Journal

Doc of Prophage P1 Is Inhibited by Its Antitoxin Partner Phd through Fold Complementation

(2008) Abel Garcia-Pino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Mechanism of Transcriptional Autorepression of the Escherichia coli RelB/RelE Antitoxin/Toxin Module

(2008) Guang-Yao Li et al.   JOURNAL OF MOLECULAR BIOLOGY