Long noncoding RNAs as versatile molecular regulators of cellular stress response and homeostasis

Long non-coding RNAs: definitions, functions, challenges and recommendations

(2023) John S. Mattick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long noncoding RNA and phase separation in cellular stress response

(2022) Rena Onoguchi-Mizutani et al.   JOURNAL OF BIOCHEMISTRY

SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage

(2022) Karla F. Meza-Sosa et al.   MOLECULAR CELL

Substoichiometric action of long noncoding RNAs

(2022) Juan Pablo Unfried et al.   NATURE CELL BIOLOGY

Functional elements of the cis-regulatory lincRNA-p21

(2022) Lauren Winkler et al.   Cell Reports

A Unique Spectrum of Spontaneous Tumors in Dino Knockout Mice Identifies Tissue-Specific Requirements for Tumor Suppression

(2022) Christina Marney et al.   Cells

AATF /Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma

(2022) Tiziana Bruno et al.   EMBO JOURNAL

The long noncoding RNA Malat1 regulates CD8+ T cell differentiation by mediating epigenetic repression

(2022) Jad N. Kanbar et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Cellular Ribonucleoprotein Granules: From Assembly to Degradation via Post-translational Modification

(2022) Pureum Jeon et al.   Cells

Long non-coding RNA Neat1 and paraspeckle components are translational regulators in hypoxia

(2022) Anne-Claire Godet et al.   eLife

Identification of heat-inducible long noncoding RNA MALAT1-containing novel nuclear (HiNoCo) body

(2021) Rena Onoguchi-Mizutani et al.   JOURNAL OF CELL SCIENCE

LncRNA GIRGL drives CAPRIN1-mediated phase separation to suppress glutaminase-1 translation under glutamine deprivation

(2021) Ruijie Wang et al.   Science Advances

The Integral Role of RNA in Stress Granule Formation and Function

(2021) Danae Campos-Melo et al.   Frontiers in Cell and Developmental Biology

NORAD-induced Pumilio phase separation is required for genome stability

(2021) Mahmoud M. Elguindy et al.   NATURE

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

(2021) Christina B. Marney et al.   Cell Reports

The dark proteome: translation from noncanonical open reading frames

(2021) Bradley W. Wright et al.   TRENDS IN CELL BIOLOGY

p53 Activates the Long Noncoding RNA Pvt1b to Inhibit Myc and Suppress Tumorigenesis

(2020) Christiane E. Olivero et al.   MOLECULAR CELL

Long Noncoding RNAs: Molecular Modalities to Organismal Functions

(2020) John L. Rinn et al.   Annual Review of Biochemistry

Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation

(2020) Chen Wang et al.   MOLECULAR CELL

The lncRNA Growth Arrest Specific 5 Regulates Cell Survival via Distinct Structural Modules with Independent Functions

(2020) Filipp Frank et al.   Cell Reports

Long non-coding RNAs: emerging players regulating plant abiotic stress response and adaptation

(2020) Uday Chand Jha et al.   BMC PLANT BIOLOGY

RNA partitioning into stress granules is based on the summation of multiple interactions

(2020) Tyler Matheny et al.   RNA

PUMILIO hyperactivity drives premature aging of Norad-deficient mice

(2019) Florian Kopp et al.   eLife

Past, present, and future of circ RNA s

(2019) Ines Lucia Patop et al.   EMBO JOURNAL

PUMILIO, but not RBMX, binding is required for regulation of genomic stability by noncoding RNA NORAD

(2019) Mahmoud M Elguindy et al.   eLife

The long noncoding RNA NKILA protects against myocardial ischaemic injury by enhancing myocardin expression via suppressing the NF-κB signalling pathway

(2019) Qing Liu et al.   EXPERIMENTAL CELL RESEARCH

Functional Classification and Experimental Dissection of Long Noncoding RNAs

(2018) Florian Kopp et al.   CELL

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element

(2018) Seung Woo Cho et al.   CELL

Diminished nuclear RNA decay upon Salmonella infection upregulates antibacterial noncoding RNAs

(2018) Katsutoshi Imamura et al.   EMBO JOURNAL

Systematic Characterization of Stress-Induced RNA Granulation

(2018) Sim Namkoong et al.   MOLECULAR CELL

Functional Domains of NEAT1 Architectural lncRNA Induce Paraspeckle Assembly through Phase Separation

(2018) Tomohiro Yamazaki et al.   MOLECULAR CELL

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

(2018) Wang Lai Hu et al.   NATURE CELL BIOLOGY

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria

(2018) Yang Wang et al.   NATURE CELL BIOLOGY

NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death

(2018) Di Huang et al.   NATURE IMMUNOLOGY

The long noncoding RNA NEAT1 and nuclear paraspeckles are up-regulated by the transcription factor HSF1 in the heat shock response

(2018) S. Mohammad Lellahi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

(2018) Aaron C. Goldstrohm et al.   TRENDS IN GENETICS

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response

(2017) Joshua R. Porter et al.   MOLECULAR CELL

The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

(2017) Anthony Khong et al.   MOLECULAR CELL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mining for Micropeptides

(2017) Catherine A. Makarewich et al.   TRENDS IN CELL BIOLOGY

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer

(2017) Xiao Ling Li et al.   Cell Reports

Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3

(2017) Ritu Chaudhary et al.   eLife

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

(2016) Sungyul Lee et al.   CELL

The integrated stress response

(2016) Karolina Pakos‐Zebrucka et al.   EMBO REPORTS

The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB

(2016) Gui Zhao et al.   FEBS LETTERS

Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development

(2016) Kelly M. Anderson et al.   NATURE

Local regulation of gene expression by lncRNA promoters, transcription and splicing

(2016) Jesse M. Engreitz et al.   NATURE

An inducible long noncoding RNA amplifies DNA damage signaling

(2016) Adam M Schmitt et al.   NATURE GENETICS

A conserved abundant cytoplasmic long noncoding RNA modulates repression by Pumilio proteins in human cells

(2016) Ailone Tichon et al.   Nature Communications

In Vivo Characterization of Linc-p21 Reveals Functional cis -Regulatory DNA Elements

(2016) Abigail F. Groff et al.   Cell Reports

Long noncoding RNAs in the p53 network

(2016) Ritu Chaudhary et al.   Wiley Interdisciplinary Reviews-RNA

A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis

(2015) Bodu Liu et al.   CANCER CELL

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

(2014) Katharina M. Michalik et al.   CIRCULATION RESEARCH

Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli

(2014) Katsutoshi Imamura et al.   MOLECULAR CELL

LincRNA-p21 Activates p21 In cis to Promote Polycomb Target Gene Expression and to Enforce the G1/S Checkpoint

(2014) Nadya Dimitrova et al.   MOLECULAR CELL

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

An update on LNCipedia: a database for annotated human lncRNA sequences

(2014) Pieter-Jan Volders et al.   NUCLEIC ACIDS RESEARCH

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival

(2014) H Choudhry et al.   ONCOGENE

Transcriptional regulation of the stress response by mTOR

(2014) J. Aramburu et al.   Science Signaling

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

(2014) William H. Hudson et al.   Nature Communications

lincRNAs: Genomics, Evolution, and Mechanisms

(2013) Igor Ulitsky et al.   CELL

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles

(2012) Takao Naganuma et al.   EMBO JOURNAL

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Loss of the abundant nuclear non-coding RNAMALAT1is compatible with life and development

(2012) Moritz Eißmann et al.   RNA Biology

Malat1 is not an essential component of nuclear speckles in mice

(2012) S. Nakagawa et al.   RNA

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

Cellular stress response pathways and ageing: intricate molecular relationships

(2011) Nikos Kourtis et al.   EMBO JOURNAL

Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

(2011) Tiffany Hung et al.   NATURE GENETICS

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Paraspeckles

(2010) A. H. Fox et al.   Cold Spring Harbor Perspectives in Biology

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

(2009) Christine M. Clemson et al.   MOLECULAR CELL

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

(2009) Yasnory T. F. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL

MEN  /  nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles

(2008) H. Sunwoo et al.   GENOME RESEARCH