Regulation of lipid synthesis in myelin modulates neural activity and is required for motor learning

From seconds to days: Neural plasticity viewed through a lipid lens

(2023) John P. Vaughen et al.   CURRENT OPINION IN NEUROBIOLOGY

Overview of myelin, major myelin lipids, and myelin-associated proteins

(2023) Alexander Kister et al.   Frontiers in Chemistry

Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia

(2022) Liping Wang et al.   Science Advances

Periods of synchronized myelin changes shape brain function and plasticity

(2021) Omar de Faria et al.   NATURE NEUROSCIENCE

Myelin makes memories

(2020) R. Douglas Fields et al.   NATURE NEUROSCIENCE

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders

(2020) Sukanthini Thurairatnam et al.   ACS Medicinal Chemistry Letters

Sphingomyelin(d35:1) as a novel predictor for lung adenocarcinoma recurrence after a radical surgery: a case-control study

(2020) Yusuke Takanashi et al.   BMC CANCER

Myelin plasticity: sculpting circuits in learning and memory

(2020) Wendy Xin et al.   NATURE REVIEWS NEUROSCIENCE

Myelin development in cerebral gray and white matter during adolescence and late childhood

(2020) Neva M. Corrigan et al.   NEUROIMAGE

Role of cholesterol and sphingolipids in brain development and neurological diseases

(2019) Ghulam Hussain et al.   Lipids in Health and Disease

Exogenous Galactosylceramide as Potential Treatment for CLN3 Disease

(2019) Sally El‐Sitt et al.   ANNALS OF NEUROLOGY

Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity

(2019) Daisuke Kato et al.   GLIA

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

(2019) Ying Sun et al.   eLife

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Role of sphingolipids in senescence: implication in aging and age-related diseases

(2018) Magali Trayssac et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease

(2018) Rajanikanth J. Maganti et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation

(2017) Shinji Go et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

White Matter Plasticity in the Adult Brain

(2017) Cassandra Sampaio-Baptista et al.   NEURON

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network

(2016) Seonjoo Lee et al.   ANNALS OF NEUROLOGY

Oligodendroglial membrane dynamics in relation to myelin biogenesis

(2016) Hande Ozgen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A sphingolipid mechanism for behavioral extinction

(2016) Joseph P. Huston et al.   JOURNAL OF NEUROCHEMISTRY

Rapid production of new oligodendrocytes is required in the earliest stages of motor-skill learning

(2016) Lin Xiao et al.   NATURE NEUROSCIENCE

Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease

(2016) Timothy A. Couttas et al.   NEUROBIOLOGY OF AGING

Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains

(2015) Masayuki Sugimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A new mechanism of nervous system plasticity: activity-dependent myelination

(2015) R. Douglas Fields   NATURE REVIEWS NEUROSCIENCE

Selective information routing by ventral hippocampal CA1 projection neurons

(2015) S. Ciocchi et al.   SCIENCE

Emergence of reproducible spatiotemporal activity during motor learning

(2014) Andrew J. Peters et al.   NATURE

Two distinct layer-specific dynamics of cortical ensembles during learning of a motor task

(2014) Yoshito Masamizu et al.   NATURE NEUROSCIENCE

Diffusion tensor imaging of white matter degeneration in Alzheimer’s disease and mild cognitive impairment

(2014) I.K. Amlien et al.   NEUROSCIENCE

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy

(2014) Anthony S Don et al.   Acta Neuropathologica Communications

Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination

(2013) C. Sampaio-Baptista et al.   JOURNAL OF NEUROSCIENCE

Disconnected aging: Cerebral white matter integrity and age-related differences in cognition

(2013) I.J. Bennett et al.   NEUROSCIENCE

White matter lesions defined by diffusion tensor imaging in older adults

(2011) Stephen A. Back et al.   ANNALS OF NEUROLOGY

Self-Segregation of Myelin Membrane Lipids in Model Membranes

(2011) Larisa Yurlova et al.   BIOPHYSICAL JOURNAL

Control of Local Protein Synthesis and Initial Events in Myelination by Action Potentials

(2011) H. Wake et al.   SCIENCE

Central nervous system myelin: structure, synthesis and assembly

(2011) Shweta Aggarwal et al.   TRENDS IN CELL BIOLOGY

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase

(2009) Vineet Gupta et al.   JOURNAL OF LIPID RESEARCH

Mice with Altered Myelin Proteolipid Protein Gene Expression Display Cognitive Deficits Accompanied by Abnormal Neuron-Glia Interactions and Decreased Conduction Velocities

(2009) H. Tanaka et al.   JOURNAL OF NEUROSCIENCE

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

(2009) Lin Tian et al.   NATURE METHODS

Training induces changes in white-matter architecture

(2009) Jan Scholz et al.   NATURE NEUROSCIENCE