Leonurine pretreatment protects the heart from myocardial ischemia-reperfusion injury

Identification of a Hydrogen-Sulfide-Releasing Isochroman-4-One Hybrid as a Cardioprotective Candidate for the Treatment of Cardiac Hypertrophy

(2022) Yu Wang et al.   MOLECULES

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Pristimerin‐induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway

(2020) Fengxia Yan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Design and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations

(2020) Shanshan Luo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Leonurus japonicus (Chinese motherwort), an excellent traditional medicine for obstetrical and gynecological diseases: A comprehensive overview

(2019) Lu-Lin Miao et al.   BIOMEDICINE & PHARMACOTHERAPY

Transplantation of Human Umbilical Cord Blood–Derived Cellular Fraction Improves Left Ventricular Function and Remodeling After Myocardial Ischemia/Reperfusion

(2019) Lin Zhao et al.   CIRCULATION RESEARCH

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

(2019) Dominic P. Del Re et al.   PHYSIOLOGICAL REVIEWS

Promoting effect of baicalin on nitric oxide production in CMECs via activating the PI3K-AKT-eNOS pathway attenuates myocardial ischemia–reperfusion injury

(2019) Jiannan Bai et al.   PHYTOMEDICINE

Predictive Value of High Sensitivity-Troponin T for Systolic Dysfunction and Infarct Size (6 months) after ST-Elevation Myocardial Infarction

(2018) Moman A Mohammad et al.   AMERICAN JOURNAL OF CARDIOLOGY

Changes in Serum Fibroblast Growth Factor 23 in Patients With Acute Myocardial Infarction

(2018) Hideaki Takahashi et al.   CIRCULATION JOURNAL

Discovery of Leonuri and therapeutical applications: From bench to bedside

(2018) Yi Zhun Zhu et al.   PHARMACOLOGY & THERAPEUTICS

Roles of melatonin and its receptors in cardiac ischemia–reperfusion injury

(2018) Kodchanan Singhanat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Shenxian-Shengmai Oral Liquid Reduces Myocardial Oxidative Stress and Protects Myocardium from Ischemia-Reperfusion Injury

(2018) Yixiu Zhao et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Acute Mechanical LV Unloading in Ischemia Reperfusion Injury

(2018) Kiyotake Ishikawa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors

(2018) Carmen Fiuza-Luces et al.   Nature Reviews Cardiology

Phytochemistry and pharmacology of the genus Leonurus : The herb to benefit the mothers and more

(2018) Rui-Han Zhang et al.   PHYTOCHEMISTRY

Ligustrazine Exerts Cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms

(2018) Qun Zheng et al.   Frontiers in Pharmacology

Pterostilbene protects against myocardial ischemia/reperfusion injury via suppressing oxidative/nitrative stress and inflammatory response

(2017) Zhaoxia Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation

(2017) Miaomiao Jia et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cardioprotective effects and mechanism of Radix Salviae miltiorrhizae and Lignum Dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury

(2017) Fei Mu et al.   Molecular Medicine Reports

PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction

(2017) Xue Qiao et al.   Scientific Reports

Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats

(2016) F. Ma et al.   BIOSCIENCE REPORTS

Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia

(2016) James Cheng-Chung Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1

(2016) Kyung-Hye Roh et al.   FREE RADICAL BIOLOGY AND MEDICINE

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways

(2015) Feng-Lai Yuan et al.   BONE

“Wild cannabis”: A review of the traditional use and phytochemistry of Leonotis leonurus

(2015) Baudry N. Nsuala et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cardiac H2S Generation Is Reduced in Ageing Diabetic Mice

(2015) Sheng Jin et al.   Oxidative Medicine and Cellular Longevity

NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury

(2015) Xiaojuan Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Synergistic Signaling of Tumor Cell Invasiveness by Hepatocyte Growth Factor and Hypoxia

(2014) Young H. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cardioprotective Effect of Protocatechuic Acid on Myocardial Ischemia/Reperfusion Injury

(2014) Xi-Lan Tang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The rheostat in the membrane: BCL-2 family proteins and apoptosis

(2013) N Volkmann et al.   CELL DEATH AND DIFFERENTIATION

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leonurine: A new comer in the natural compounds affecting atherosclerosis

(2012) Giuseppe Danilo Norata et al.   ATHEROSCLEROSIS

Effects of Leonurine on L-Type Calcium Channel in Rat Ventricular Myocytes

(2012) Hong Xin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: Involvement of reactive oxygen species and NF-κB pathways

(2012) Xin Hua Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4

(2012) Xin-Hua Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quantification of leonurine, a novel potential cardiovascular agent, in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in rats

(2011) Qing Zhu et al.   BIOMEDICAL CHROMATOGRAPHY

Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases

(2011) Xin H Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Protective effects of alkaloid extract from Leonurus heterophyllus on cerebral ischemia reperfusion injury by middle cerebral ischemic injury (MCAO) in rats

(2011) Hao Liang et al.   PHYTOMEDICINE

Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction

(2010) XinHua Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leonurine improves ischemia-induced myocardial injury through antioxidative activity

(2010) X.H. Liu et al.   PHYTOMEDICINE

Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure

(2009) Xiao-Mei Li et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Profound Hypothermia Decreases Cardiac Apoptosis Through Akt Survival Pathway

(2009) Fahad Shuja et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS