Ammonia toxicity to the brain

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure

(2012) Cristina R. Bosoi et al.   FREE RADICAL BIOLOGY AND MEDICINE

583 ASSESSMENT OF CEREBRAL OSMOTIC REGULATION IN A RAT MODEL OF BILIARY CIRRHOSIS USING MR SPECTROSCOPY

(2012) V.A. McLin et al.   JOURNAL OF HEPATOLOGY

Creatine and guanidinoacetate transport at blood-brain and blood-cerebrospinal fluid barriers

(2012) Olivier Braissant   JOURNAL OF INHERITED METABOLIC DISEASE

Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases

(2012) Marta Skowrońska et al.   JOURNAL OF NEUROCHEMISTRY

Developmental Assessment of Infants With Biliary Atresia

(2012) Susan E. Caudle et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Glutamine in the pathogenesis of acute hepatic encephalopathy

(2012) Kakulavarapu V. Rama Rao et al.   NEUROCHEMISTRY INTERNATIONAL

Upregulation of the heteromeric y+LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes

(2012) Magdalena Zielińska et al.   NEUROCHEMISTRY INTERNATIONAL

Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy?

(2012) Roger F. Butterworth   NEUROCHEMISTRY INTERNATIONAL

Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: Role of glutamine redefined

(2012) Paul Desjardins et al.   NEUROCHEMISTRY INTERNATIONAL

Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy

(2012) Carmina Montoliu et al.   NEUROIMAGE

Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy

(2012) A.R. Jayakumar et al.   NEUROSCIENCE

Rifaximinvsconventional oral therapy for hepatic encephalopathy: A meta-analysis

(2012) Karim M Eltawil   WORLD JOURNAL OF GASTROENTEROLOGY

Review article: the design of clinical trials in hepatic encephalopathy - an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement

(2011) J. S. Bajaj et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Creatine deficiency syndromes and the importance of creatine synthesis in the brain

(2011) Olivier Braissant et al.   AMINO ACIDS

Clinical features of congenital portosystemic shunt in children

(2011) Myung Jin Kim et al.   EUROPEAN JOURNAL OF PEDIATRICS

p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts

(2011) A. Agusti et al.   GUT

Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: A cost-effectiveness analysis

(2011) Jasmohan S. Bajaj et al.   HEPATOLOGY

Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

(2011) Vicente Felipo et al.   HEPATOLOGY

Cerebral Glutamine Metabolism under Hyperammonemia Determined in vivo by Localized 1H and 15N NMR Spectroscopy

(2011) Cristina Cudalbu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ornithine phenylacetate prevents disturbances of motor-evoked potentials induced by intestinal blood in rats with portacaval anastomosis

(2011) Marc Oria et al.   JOURNAL OF HEPATOLOGY

Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy

(2011) Marta Obara-Michlewska et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interaction between cytokines and ammonia in the mitochondrial permeability transition in cultured astrocytes

(2011) Veronica M. Alvarez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure

(2011) Amruta A. Jambekar et al.   LIVER INTERNATIONAL

Inhibition of glutamine synthesis induces glutamate dehydrogenase-dependent ammonia fixation into alanine in co-cultures of astrocytes and neurons

(2011) Sherry Dadsetan et al.   NEUROCHEMISTRY INTERNATIONAL

Neuroimaging in acute liver failure

(2011) Laia Chavarria et al.   NEUROCHEMISTRY INTERNATIONAL

Diffusion Tensor Imaging Detects Areas of Abnormal White Matter Microstructure in Patients with Partial Ornithine Transcarbamylase Deficiency

(2010) A.L. Gropman et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal

(2010) Jan Albrecht et al.   BIOCHEMICAL PHARMACOLOGY

Brain Region-Selective Mechanisms Contribute to the Progression of Cerebral Alterations in Acute Liver Failure in Rats

(2010) Omar Cauli et al.   GASTROENTEROLOGY

Encephalopathy assessment in children with extra-hepatic portal vein obstruction with MR, psychometry and critical flicker frequency

(2010) Santosh K. Yadav et al.   JOURNAL OF HEPATOLOGY

The Na–K–Cl cotransporter in the brain edema of acute liver failure

(2010) Arumugam R. Jayakumar et al.   JOURNAL OF HEPATOLOGY

Synthesis and transport of creatine in the CNS: importance for cerebral functions

(2010) Elidie Béard et al.   JOURNAL OF NEUROCHEMISTRY

Brain Aquaporin-4 in Experimental Acute Liver Failure

(2010) Kakulavarapu V. Rama Rao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Language and Motor Skills Are Impaired in Infants with Biliary Atresia Before Transplantation

(2010) Susan E. Caudle et al.   JOURNAL OF PEDIATRICS

The Na–K–Cl Co-transporter in astrocyte swelling

(2010) Arumugam R. Jayakumar et al.   METABOLIC BRAIN DISEASE

Alternative pathway or diversion therapy for urea cycle disorders now and in the future

(2010) Stephen Cederbaum et al.   MOLECULAR GENETICS AND METABOLISM

Brain imaging in urea cycle disorders

(2010) Andrea Gropman   MOLECULAR GENETICS AND METABOLISM

Nitrogen sparing therapy revisited 2009

(2010) Gregory M. Enns   MOLECULAR GENETICS AND METABOLISM

New insights in nutritional management and amino acid supplementation in urea cycle disorders

(2010) Fernando Scaglia   MOLECULAR GENETICS AND METABOLISM

Creatine metabolism and the urea cycle

(2010) John T. Brosnan et al.   MOLECULAR GENETICS AND METABOLISM

Liver, liver cell and stem cell transplantation for the treatment of urea cycle defects

(2010) Jochen Meyburg et al.   MOLECULAR GENETICS AND METABOLISM

Current concepts in the pathogenesis of urea cycle disorders

(2010) Olivier Braissant   MOLECULAR GENETICS AND METABOLISM

Ammonia toxicity to the brain: Effects on creatine metabolism and transport and protective roles of creatine

(2010) Olivier Braissant   MOLECULAR GENETICS AND METABOLISM

Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+LAT2 in rat cerebral cortex: Implications for the nitric oxide/cGMP pathway

(2010) Magdalena Zielińska et al.   NEUROCHEMISTRY INTERNATIONAL

Rifaximin Treatment in Hepatic Encephalopathy

(2010) Nathan M. Bass et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extrahepatic portal vein thrombosis in children and adolescents: Influence of genetic thrombophilic disorders

(2010) Andrea Pietrobattista   WORLD JOURNAL OF GASTROENTEROLOGY

Minimal Hepatic Encephalopathy in Children: Evaluation with Proton MR Spectroscopy

(2009) B.R. Foerster et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Ammonia toxicity and its prevention in inherited defects of the urea cycle

(2009) V. Walker   DIABETES OBESITY & METABOLISM

Diffusion Tensor Imaging Supports the Cytotoxic Origin of Brain Edema in a Rat Model of Acute Liver Failure

(2009) Laia Chavarria et al.   GASTROENTEROLOGY

Experimental models of hepatic encephalopathy: ISHEN guidelines

(2009) Roger F. Butterworth et al.   LIVER INTERNATIONAL

MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T

(2009) Ralf Mekle et al.   MAGNETIC RESONANCE IN MEDICINE

In vivo1H NMR spectroscopy of the human brain at high magnetic fields: Metabolite quantification at 4T vs. 7T

(2009) Ivan Tkáč et al.   MAGNETIC RESONANCE IN MEDICINE

Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake

(2009) K.S. Panickar et al.   NEUROCHEMISTRY INTERNATIONAL

Role of NMDA receptors in acute liver failure and ammonia toxicity: Therapeutical implications

(2009) Regina Rodrigo et al.   NEUROCHEMISTRY INTERNATIONAL

Diffusion Tensor Imaging in Arginase Deficiency Reveals Damage to Corticospinal Tracts

(2009) Michael S. Oldham et al.   PEDIATRIC NEUROLOGY

Intellectual, Adaptive, and Behavioral Functioning in Children With Urea Cycle Disorders

(2009) Lauren Krivitzky et al.   PEDIATRIC RESEARCH

MR Imaging Findings in Hepatic Encephalopathy

(2008) A. Rovira et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Brain cholinergic impairment in liver failure

(2008) M.-S. Garcia-Ayllon et al.   BRAIN

Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency

(2008) Olivier Braissant et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gene expression profiling of astrocytes from hyperammonemic mice reveals altered pathways for water and potassium homeostasisin vivo

(2008) Uta Lichter-Konecki et al.   GLIA

1H NMR spectroscopy of rat brain in vivo at 14.1Tesla: Improvements in quantification of the neurochemical profile

(2008) Vladimír Mlynárik et al.   JOURNAL OF MAGNETIC RESONANCE

Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy

(2008) Omar Cauli et al.   METABOLIC BRAIN DISEASE

Contrasting features of urea cycle disorders in human patients and knockout mouse models

(2008) Joshua L. Deignan et al.   MOLECULAR GENETICS AND METABOLISM

Cross-sectional multicenter study of patients with urea cycle disorders in the United States

(2008) Mendel Tuchman et al.   MOLECULAR GENETICS AND METABOLISM

Role of caspases, calpain and cdk5 in ammonia-induced cell death in developing brain cells

(2008) Laurène Cagnon et al.   NEUROBIOLOGY OF DISEASE

CNTF protects oligodendrocytes from ammonia toxicity: Intracellular signaling pathways involved

(2008) Laurène Cagnon et al.   NEUROBIOLOGY OF DISEASE

Neurologic Damage and Neurocognitive Dysfunction in Urea Cycle Disorders

(2008) Gregory M. Enns   Seminars in Pediatric Neurology