Physiologically based pharmacokinetic modeling to characterize enterohepatic recirculation and predict food effect on the pharmacokinetics of hyzetimibe

Regulatory utility of physiologically based pharmacokinetic modeling for assessing food impact in bioequivalence studies: A workshop summary report

(2023) Abdullah Al Shoyaib et al.   CPT-Pharmacometrics & Systems Pharmacology

Investigation of the discriminatory ability of analytes for the bioequivalence assessment of ezetimibe: Parent drug, metabolite, total form, and combination of parent drug and total form

(2022) Chien-Ming Hsieh et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically based pharmacokinetic (PBPK) modeling of BDE-209 following oral exposure in Chinese population

(2022) Zhichun Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Physiologically Based Pharmacokinetic Models Are Effective Support for Pediatric Drug Development

(2021) Kefei Wang et al.   AAPS PHARMSCITECH

Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population

(2021) Sara N. Salerno et al.   DRUG METABOLISM AND DISPOSITION

Pharmacokinetic Study of Oral 14C-Radiolabeled Hyzetimibe, A New Cholesterol Absorption Inhibitor

(2021) Jianwei Liao et al.   Frontiers in Pharmacology

Development, Testing, Parameterisation and Calibration of a Human PBPK Model for the Plasticiser, Di-(2-propylheptyl) Phthalate (DPHP) Using in Silico, in vitro and Human Biomonitoring Data

(2021) Kevin McNally et al.   Frontiers in Pharmacology

Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug–Drug Interaction with Rifampin and Liver Impairment

(2021) Bettina Gerner et al.   Pharmaceutics

Population pharmacokinetics and enterohepatic recirculation of hyzetimibe and its main metabolite in Chinese healthy subjects

(2021) Wenjun Chen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool

(2020) Lisa Cheng et al.   Pharmaceutics

Physiologically‐Based Pharmacokinetic (PBPK) Model of Morphine and Morphine‐3‐Glucuronide in Nonalcoholic Steatohepatitis (NASH)

(2020) Noora Sjöstedt et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pharmacokinetics, pharmacodynamics, safety, and tolerability of hyzetimibe (HS-25) in healthy Chinese subjects

(2014) Zhourong Ruan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Assessment of Bisphenol a Exposure in Korean Pregnant Women by Physiologically Based Pharmacokinetic Modeling

(2010) Beom Soo Shin et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES