Nitroimidazole derivatives potentiated against tumor hypoxia: Design, synthesis, antitumor activity, molecular docking study, and QSAR study

Nitroimidazole-sulfonamides as carbonic anhydrase IX and XII inhibitors targeting tumor hypoxia: Design, synthesis, molecular docking and molecular dynamics simulation

(2022) Aya M. Almatary et al.   JOURNAL OF MOLECULAR STRUCTURE

Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells

(2020) Min Kyung Park et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361

(2019) Way Wua Wong et al.   BIOCHEMICAL PHARMACOLOGY

Design, synthesis and biological evaluation of pyrimidine derivatives as novel CDK2 inhibitors that induce apoptosis and cell cycle arrest in breast cancer cells

(2018) Yiting Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Next-Generation Hypoxic Cell Radiosensitizers: Nitroimidazole Alkylsulfonamides

(2018) Muriel Bonnet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrated omics profiling identifies hypoxia-regulated genes in HCT116 colon cancer cells

(2018) Jeng-Ting Chen et al.   Journal of Proteomics

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole

(2018) Teresa Glomb et al.   MOLECULES

Improving radiotherapy in cancer treatment: Promises and challenges

(2017) Helen H.W. Chen et al.   Oncotarget

Recent Developments on 1,2,4-Triazole Nucleus in Anticancer Compounds: A Review

(2016) Ramandeep Kaur et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis and evaluation of benzosuberone embedded with 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole moieties as new potential anti proliferative agents

(2015) Bandi Yadagiri et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro antiproliferative activity of new 1,3,4-oxadiazole derivatives possessing sulfonamide moiety

(2015) Mahmoud M. Gamal El-Din et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

(2014) Tummala R.K. Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NIMRAD – A Phase III Trial to Investigate the Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer

(2014) D. Thomson et al.   CLINICAL ONCOLOGY

1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells

(2014) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

(2013) Hu Wang et al.   MOLECULAR CARCINOGENESIS

Syntheses of 2-Nitroimidazole Derivatives Conjugated with 1,4,7-Triazacyclononane-N,N′-Diacetic Acid Labeled with F-18 Using an Aluminum Complex Method for Hypoxia Imaging

(2012) Lathika Hoigebazar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zibotentan for the treatment of castrate-resistant prostate cancer

(2010) Dale R Shepard et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

(2009) Mosaad S.M. Abd alla et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Convenient syntheses of 5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole-2(3H)thione and N-substituted 2-amino-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-thiadiazoles

(2009) Javad Mirzaei et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY