Nitroimidazole-sulfonamides as carbonic anhydrase IX and XII inhibitors targeting tumor hypoxia: Design, synthesis, molecular docking and molecular dynamics simulation

Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy

(2020) Yvain Gerard et al.   BIOORGANIC CHEMISTRY

Methazolamide in high-altitude illnesses

(2020) Hui Lu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

An update on drug interaction considerations in the therapeutic use of carbonic anhydrase inhibitors

(2020) Claudiu T. Supuran   Expert Opinion on Drug Metabolism & Toxicology

Antibacterial activity of ethoxzolamide against Helicobacter pylori strains SS1 and 26695

(2020) Mohammad M. Rahman et al.   Gut Pathogens

Hypoxia activated prodrug evofosfamide treatment in pancreatic ductal adenocarcinoma xenografts alters the tumor redox status to potentiate radiotherapy.

(2020) Shun Kishimoto et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides

(2017) Mam Y. Mboge et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII

(2017) Matteo Falsini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia-Sensitive Materials for Biomedical Applications

(2016) Jicheng Yu et al.   ANNALS OF BIOMEDICAL ENGINEERING

Dichlorphenamide: A Review in Primary Periodic Paralyses

(2016) Sarah L. Greig   DRUGS

Design and synthesis of some novel 4-Chloro- N -(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide derivatives as anticancer and radiosensitizing agents

(2016) Mostafa M. Ghorab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011–2016)

(2016) Carrie Lomelino et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

(2016) Caroline Wigerup et al.   PHARMACOLOGY & THERAPEUTICS

Design, synthesis and biological evaluation of 6-(nitroimidazole-1H-alkyloxyl)-4-anilinoquinazolines as efficient EGFR inhibitors exerting cytotoxic effects both under normoxia and hypoxia

(2015) Weiyan Cheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pharmacotherapy of Glaucoma

(2015) Doreen Schmidl et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

NIMRAD – A Phase III Trial to Investigate the Use of Nimorazole Hypoxia Modification with Intensity-modulated Radiotherapy in Head and Neck Cancer

(2014) D. Thomson et al.   CLINICAL ONCOLOGY

The Role of the Acidity of N-Heteroaryl Sulfonamides as Inhibitors of Bcl-2 Family Protein–Protein Interactions

(2013) B. Barry Touré et al.   ACS Medicinal Chemistry Letters

A fluorous and click approach for screening potential PET probes: Evaluation of potential hypoxia biomarkers

(2011) Romain Bejot et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antitumor activity of new sulfonamide derivatives of thiadiazolo[3,2-a]pyrimidines

(2011) Nadia S. El-Sayed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE