Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis

METTL3 promotes colorectal carcinoma progression by regulating the m6A–CRB3–Hippo axis

(2022) Jiashu Pan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ManNAc protects against podocyte pyroptosis via inhibiting mitochondrial damage and ROS/NLRP3 signaling pathway in diabetic kidney injury model

(2022) Yanmin Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis

(2022) Mei-Zi Wang et al.   Frontiers in Pharmacology

MicroRNA-223 downregulation promotes HBx-induced podocyte pyroptosis by targeting the NLRP3 inflammasome

(2022) Yani Yu et al.   ARCHIVES OF VIROLOGY

SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species

(2021) Zhou Yang et al.   Cell Death & Disease

Cyclosporine modulates neutrophil functions via the SIRT6–HIF‐1α–glycolysis axis to alleviate severe ulcerative colitis

(2021) Huiying Lu et al.   Clinical and Translational Medicine

Sirtuin 6: linking longevity with genome and epigenome stability

(2021) Anatoly Korotkov et al.   TRENDS IN CELL BIOLOGY

FOXM1-activated SIRT4 inhibits NF-κB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy

(2021) Xiaohong Xu et al.   EXPERIMENTAL CELL RESEARCH

Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis

(2021) Wei Zhu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Insulin Resistance Associated with Clinical Manifestations of Diabetic Kidney Disease (Glomerular Hyperfiltration, Albuminuria, and Kidney Function Decline)

(2021) María M. Adeva-Andany et al.   CURRENT DIABETES REVIEWS

Protective Effects of SIRT6 Against Inflammation, Oxidative Stress, and Cell Apoptosis in Spinal Cord Injury

(2020) Chen Zhaohui et al.   INFLAMMATION

Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association: national cross sectional study

(2020) Yongze Li et al.   BMJ-British Medical Journal

Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway

(2020) Jiye Li et al.   Cell and Bioscience

The SIRT6 activator MDL‐800 improves genomic stability and pluripotency of old murine‐derived iPS cells

(2020) Yu Chen et al.   AGING CELL

Ling-gui-zhu-gan decoction alleviates hepatic steatosis through SOCS2 modification by N6-methyladenosine

(2020) Yanqi Dang et al.   BIOMEDICINE & PHARMACOTHERAPY

Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis

(2020) Yanqi Dang et al.   BIOMEDICINE & PHARMACOTHERAPY

Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic nephropathy

(2020) Qian Cheng et al.   ACTA PHARMACOLOGICA SINICA

Astragaloside IV attenuates gestational diabetes mellitus via targeting NLRP3 inflammasome in genetic mice

(2019) Ruixue Zhang et al.   Reproductive Biology and Endocrinology

The Role of Sirtuins in Antioxidant and Redox Signaling

(2018) Chandra K. Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

The Role of Sirt6 in Obesity and Diabetes

(2018) Jiangying Kuang et al.   Frontiers in Physiology

Live or Let Die: Is There any Cell Death in Podocytes?

(2016) Fabian Braun et al.   SEMINARS IN NEPHROLOGY

Lysine fatty acylation promotes lysosomal targeting of TNF-α

(2016) Hong Jiang et al.   Scientific Reports

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factor 1 and Cardiovascular Disease

(2013) Gregg L. Semenza   Annual Review of Physiology

Nephrology in China

(2013) Zhi-Hong Liu   Nature Reviews Nephrology

Astragaloside IV, a Novel Antioxidant, Prevents Glucose-Induced Podocyte Apoptosis In Vitro and In Vivo

(2012) Dingkun Gui et al.   PLoS One

How Many Ways Can a Podocyte Die?

(2012) Pierre-Louis Tharaux et al.   SEMINARS IN NEPHROLOGY

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

The NADPH Oxidase Subunit NOX4 Is a New Target Gene of the Hypoxia-inducible Factor-1

(2010) Isabel Diebold et al.   MOLECULAR BIOLOGY OF THE CELL

Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via α3β1 integrin upregulation and integrin-linked kinase inhibition

(2008) Jianguo Chen et al.   BIOCHEMICAL PHARMACOLOGY

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

(2008) Eriko Michishita et al.   NATURE