Stromal Interaction Molecule 1 Maintains β-Cell Identity and Function in Female Mice Through Preservation of G-Protein–Coupled Estrogen Receptor 1 Signaling

Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome

(2021) Charles Bruen et al.   PANCREAS

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

(2020) Geetanjali Sharma et al.   Science Translational Medicine

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

(2020) Maria Lytrivi et al.   BMC GENOMICS

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

(2019) Jitai Zhang et al.   Cell Death & Disease

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

The role of membrane excitability in pancreatic β-cell glucotoxicity

(2019) Zeenat A. Shyr et al.   Scientific Reports

Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes

(2019) Abu Saleh Md Moin et al.   Current Diabetes Reports

GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

(2019) Ryota Usui et al.   Scientific Reports

17β-Estradiol on the Expression of G-Protein Coupled Estrogen Receptor (GPER/GPR30) Mitophagy, and the PI3K/Akt Signaling Pathway in ATDC5 Chondrocytes In Vitro

(2018) Dong-xiao Fan et al.   MEDICAL SCIENCE MONITOR

Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β cell

(2018) Tatsuyoshi Kono et al.   DIABETES

Association of menopause and type 2 diabetes mellitus

(2018) Yongcheng Ren et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic β cell

(2018) Wataru R. Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular calcium release channels: an update

(2017) Gaetano Santulli et al.   JOURNAL OF PHYSIOLOGY-LONDON

SERCA2 Deficiency Impairs Pancreatic β-Cell Function in Response to Diet-Induced Obesity

(2016) Xin Tong et al.   DIABETES

Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+Channels in MIN6 β-Cells

(2016) Colin A. Leech et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lacking of estradiol reduces insulin exocytosis from pancreatic β-cells and increases hepatic insulin degradation

(2016) Roberta S. Santos et al.   STEROIDS

Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition

(2015) J. S. Brand et al.   HUMAN REPRODUCTION

Store-operated Ca2+Entry Mediated by Orai1 and TRPC1 Participates to Insulin Secretion in Rat β-Cells

(2015) Jessica Sabourin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

Ins1 Cre knock-in mice for beta cell-specific gene recombination

(2014) Bernard Thorens et al.   DIABETOLOGIA

Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism

(2014) J. Fadista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

(2014) Melissa F. Brereton et al.   Nature Communications

Divergent compensatory responses to high-fat diet between C57BL6/J and C57BLKS/J inbred mouse strains

(2013) Emily K. Sims et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Bilateral Oophorectomy and the Risk of Incident Diabetes in Postmenopausal Women

(2013) Duke Appiah et al.   DIABETES CARE

Role of Reduced  -Cell Mass Versus Impaired  -Cell Function in the Pathogenesis of Type 2 Diabetes

(2013) J. J. Meier et al.   DIABETES CARE

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

(2013) Steven E Kahn et al.   LANCET

Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure

(2012) Chutima Talchai et al.   CELL

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

(2012) E. Fava et al.   DIABETOLOGIA

MicroRNAs contribute to compensatory β cell expansion during pregnancy and obesity

(2012) Cécile Jacovetti et al.   JOURNAL OF CLINICAL INVESTIGATION

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

(2012) Tatsuyoshi Kono et al.   MOLECULAR ENDOCRINOLOGY

Increased hexosamine biosynthetic pathway flux dedifferentiates INS-1E cells and murine islets by an extracellular signal-regulated kinase (ERK)1/2-mediated signal transmission pathway

(2011) A. Lombardi et al.   DIABETOLOGIA

Obesity and Diabetes in Mothers and Their Children: Can We Stop the Intergenerational Cycle?

(2010) Sharon J. Herring et al.   Current Diabetes Reports

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Beneficial effect of 17β-estradiol on hyperglycemia and islet β-cell functions in a streptozotocin-induced diabetic rat model☆

(2010) Noriko Yamabe et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Importance of Extranuclear Estrogen Receptor-  and Membrane G Protein-Coupled Estrogen Receptor in Pancreatic Islet Survival

(2009) S. Liu et al.   DIABETES

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

(2008) Peter B. Stathopulos et al.   CELL

Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice

(2008) Ulrika E. A. Mårtensson et al.   ENDOCRINOLOGY

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

(2008) Masatsugu Oh-hora et al.   NATURE IMMUNOLOGY

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα

(2008) Paloma Alonso-Magdalena et al.   PLoS One