Hypoxia-induced the upregulation of NDUFA4L2 promoted colon adenocarcinoma progression through ROS-mediated PI3K/AKT pathway

PCSK9 promotes the progression and metastasis of colon cancer cells through regulation of EMT and PI3K/AKT signaling in tumor cells and phenotypic polarization of macrophages

(2022) Lu Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Downregulation of PAICS due to loss of chromosome 4q is associated with poor survival in stage III colorectal cancer

(2021) Yusuke Kobayashi et al.   PLoS One

Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer

(2021) Yu He et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis

(2021) Dan-Yun Ruan et al.   ONCOGENE

Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force

(2021) Zhengye Liu et al.   FASEB JOURNAL

Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma

(2021) Kristian B. Laursen et al.   Frontiers in Oncology

INHBA is a prognostic predictor for patients with colon adenocarcinoma

(2020) Xueying Li et al.   BMC CANCER

Extracellular vesicle long non‐coding RNAs‐mediated crosstalk in the tumor microenvironment: tiny molecules, huge roles

(2020) Wei‐long Zhang et al.   CANCER SCIENCE

Comprehensive analysis reveals a four-gene signature in colorectal cancer

(2020) Bin Zhao et al.   Translational Cancer Research

Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond

(2020) Shing Yau Tam et al.   Frontiers in Oncology

Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction

(2020) Hyocheol Bae et al.   Pharmaceutics

Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway

(2020) Pei Zhang et al.   GENE

NDUFA4L2 in smooth muscle promotes vascular remodeling in hypoxic pulmonary arterial hypertension

(2020) Yun Liu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma

(2020) Fengqi Jiang et al.   ONCOLOGY REPORTS

NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial–Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production

(2020) Wen-Ning Xu et al.   Frontiers in Cell and Developmental Biology

Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress

(2019) Lifei Meng et al.   Thoracic Cancer

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

(2019) Komal Qureshi-Baig et al.   Autophagy

Colorectal cancer

(2019) Evelien Dekker et al.   LANCET

Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway

(2019) Jinxia Qiu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling

(2018) Qingcai Meng et al.   ONCOGENE

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling

(2017) Xiaoling Song et al.   International Journal of Biological Sciences

NDUFA4L2 Fine-tunes Oxidative Stress in Hepatocellular Carcinoma

(2016) R. K.-H. Lai et al.   CLINICAL CANCER RESEARCH

NDUFA4L2 expression predicts poor prognosis in clear cell renal cell carcinoma patients

(2016) Lei Liu et al.   RENAL FAILURE

Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways

(2015) Wenjin Hao et al.   Scientific Reports

Inhibition of JAK2/STAT3 signalling induces colorectal cancer cell apoptosis via mitochondrial pathway

(2011) Wan Du et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE