The role of the antigen processing machinery in the regulation and trafficking of intracellular -Toll-like receptor molecules

Self-DNA Sensing by cGAS-STING and TLR9 in Autoimmunity: Is the Cytoskeleton in Control?

(2021) Roberto Amadio et al.   Frontiers in Immunology

UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity

(2019) Olivia Majer et al.   NATURE

Release from UNC93B1 reinforces the compartmentalized activation of select TLRs

(2019) Olivia Majer et al.   NATURE

Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy

(2019) Wei Wei et al.   CELL PROLIFERATION

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport

(2018) Karin Pelka et al.   IMMUNITY

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

(2018) Mirjana Weimershaus et al.   Cell Reports

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells

(2017) Sophia Maschalidi et al.   Nature Communications

TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

(2017) Shin-Ichiroh Saitoh et al.   Nature Communications

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

(2017) Paula Nunes-Hasler et al.   Nature Communications

Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

(2016) Marisa A. P. Baptista et al.   Nature Communications

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

(2015) Andrés Alloatti et al.   IMMUNITY

MHC Class II Presentation Is Controlled by the Lysosomal Small GTPase, Arl8b

(2015) Xavier Michelet et al.   JOURNAL OF IMMUNOLOGY

The transcription factor TFEB acts as a molecular switch that regulates exogenous antigen-presentation pathways

(2015) Mohammad Samie et al.   NATURE IMMUNOLOGY

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

Conventional Dendritic Cells Require IRAP-Rab14 Endosomes for Efficient Cross-Presentation

(2012) M. Weimershaus et al.   JOURNAL OF IMMUNOLOGY

Cell-Specific TLR9 Trafficking in Primary APCs of Transgenic TLR9-GFP Mice

(2012) A. M. Avalos et al.   JOURNAL OF IMMUNOLOGY

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

(2012) Sophia Maschalidi et al.   PLoS Pathogens

Distinct Protease Requirements for Antigen Presentation In Vitro and In Vivo

(2010) Stephen P. Matthews et al.   JOURNAL OF IMMUNOLOGY

Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells

(2010) A. L. Blasius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3

(2010) M. Sasai et al.   SCIENCE

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

(2009) Ryutaro Fukui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY