When should factorial designs be used for late-phase randomised controlled trials?

Combining factorial and multi-arm multi-stage platform designs to evaluate multiple interventions efficiently

(2022) Ian R White et al.   Clinical Trials

Imaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST)

(2022) Johnathan K. Joffe et al.   JOURNAL OF CLINICAL ONCOLOGY

Orthogonal array composite designs for drug combination experiments with applications for tuberculosis

(2022) Jose Luna et al.   STATISTICS IN MEDICINE

The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe

(2022) Steven Y C Tong et al.   CLINICAL INFECTIOUS DISEASES

Estimands for factorial trials

(2022) Brennan C. Kahan et al.   STATISTICS IN MEDICINE

Joint testing of overall and simple effects for the two-by-two factorial trial design

(2021) Eric S Leifer et al.   Clinical Trials

Multiplicity adjustments in parallel-group multi-arm trials sharing a control group: Clear guidance is needed

(2021) Síle F. Molloy et al.   Contemporary Clinical Trials

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia

(2021) Julia A. Bielicki et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The design and statistical aspects of VIETNARMS: a strategic post-licensing trial of multiple oral direct-acting antiviral hepatitis C treatment strategies in Vietnam

(2020) Leanne McCabe et al.   Trials

Testing multiple dose combinations in clinical trials

(2019) Saswati Saha et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Simulation and minimization: technical advances for factorial experiments designed to optimize clinical interventions

(2019) Jocelyn Kuhn et al.   BMC Medical Research Methodology

Reporting of randomized factorial trials was frequently inadequate

(2019) Brennan C. Kahan et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Partial factorial trials: comparing methods for statistical analysis and economic evaluation

(2018) Helen A. Dakin et al.   Trials

Two-by-Two Factorial Cancer Treatment Trials: Is Sufficient Attention Being Paid to Possible Interactions?

(2017) Boris Freidlin et al.   JNCI-Journal of the National Cancer Institute

Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa

(2017) James Hakim et al.   NEW ENGLAND JOURNAL OF MEDICINE

Some remaining challenges regarding multiple endpoints in clinical trials

(2017) Steven Snapinn   STATISTICS IN MEDICINE

Economic evaluation of factorial randomised controlled trials: challenges, methods and recommendations

(2017) Helen Dakin et al.   STATISTICS IN MEDICINE

Two-by-Two Factorial Cancer Treatment Trials: Is Sufficient Attention Being Paid to Possible Interactions?

(2017) Boris Freidlin et al.   JNCI-Journal of the National Cancer Institute

Simultaneous inference on treatment effects in survival studies with factorial designs

(2016) Dan-Yu Lin et al.   BIOMETRICS

Non-factorial analyses of two-by-two factorial trial designs

(2016) Edward L Korn et al.   Clinical Trials

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial

(2016) Nicholas D James et al.   LANCET

Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments

(2016) Thomas Jaki et al.   STATISTICS IN MEDICINE

Transfusion and Treatment of severe anaemia in African children (TRACT): a study protocol for a randomised controlled trial

(2015) Ayub Mpoya et al.   Trials

Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods

(2015) Peter D. Merrill et al.   Trials

Design, method and application of stopping rules in a phase III 2x2 factorial randomised controlled trial

(2015) Megan Bowers et al.   Trials

Factorial Experiments

(2014) Linda M. Collins et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Factorial clinical trials: a new approach to phase II neuro-oncology studies

(2014) F. M. Iwamoto et al.   NEURO-ONCOLOGY

Factorial designs: an overview with applications to orthodontic clinical trials

(2013) N. Pandis et al.   EUROPEAN JOURNAL OF ORTHODONTICS

Bias in randomised factorial trials

(2013) Brennan C. Kahan   STATISTICS IN MEDICINE

Factorial trial

(2012) Nikolaos Pandis   AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS

Efficient Designs: Factorial Randomized Trials

(2012) Daniel B Whelan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Seven useful designs

(2011) Steven A. Julious   PHARMACEUTICAL STATISTICS

Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

(2011) Marcel Wolbers et al.   Trials

Reporting of factorial trials of complex interventions in community settings: a systematic review

(2011) Alan A Montgomery et al.   Trials

Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial

(2009) Matthew R Sydes et al.   Trials