Use of Bacteriophages to Target Intracellular Pathogens

Phage-antibiotic synergy reduces Burkholderia cenocepacia population

(2023) Anna G. Mankovich et al.   BMC MICROBIOLOGY

The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy

(2023) Jacopo Marchi et al.   iScience

The Influence of Bacteriophages on the Metabolic Condition of Human Fibroblasts in Light of the Safety of Phage Therapy in Staphylococcal Skin Infections

(2023) Katarzyna Kosznik-Kwaśnicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic Engineering of Bacteriophage K1F with Human Epidermal Growth Factor to Enhance Killing of Intracellular E. coli K1

(2023) Joshua Williams et al.   ACS Synthetic Biology

A Century of Clinical Use of Phages: A Literature Review

(2023) Kevin Diallo et al.   Antibiotics-Basel

Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

(2022) Christopher JL Murray et al.   LANCET

Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa Provide Passive Resistance but Not Sensitization to LPS-Specific Phages

(2022) Daria Augustyniak et al.   Viruses-Basel

Biological foundations of successful bacteriophage therapy

(2022) Carola Venturini et al.   EMBO Molecular Medicine

Genomic characterization of lytic bacteriophages targeting genetically diverse Pseudomonas aeruginosa clinical isolates

(2022) Hayley R. Nordstrom et al.   iScience

A novel lytic phage potentially effective for phage therapy against Burkholderia pseudomallei in the tropics

(2022) Yanshuang Wang et al.   Infectious Diseases of Poverty

Nanocapping-enabled charge reversal generates cell-enterable endosomal-escapable bacteriophages for intracellular pathogen inhibition

(2022) Lu Meng et al.   Science Advances

Benefits of Combined Phage–Antibiotic Therapy for the Control of Antibiotic-Resistant Bacteria: A Literature Review

(2022) Kevin Diallo et al.   Antibiotics-Basel

Characterization and Preliminary Application of Phage Isolated From Listeria monocytogenes

(2022) Tianhao Li et al.   Frontiers in Veterinary Science

Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

(2022) Brieuc Van Nieuwenhuyse et al.   Nature Communications

Manipulation of host cell plasma membranes by intracellular bacterial pathogens

(2022) Nora Kostow et al.   CURRENT OPINION IN MICROBIOLOGY

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

(2021) Fernando Gordillo Altamirano et al.   Nature Microbiology

Bacteriophage uptake by mammalian cell layers represents a potential sink that may impact phage therapy

(2021) Marion C. Bichet et al.   iScience

Combatting intracellular pathogens using bacteriophage delivery

(2021) Avijit Goswami et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Outer Membrane Vesicles (OMVs) Produced by Gram-Negative Bacteria: Structure, Functions, Biogenesis, and Vaccine Application

(2021) Noemi Furuyama et al.   Biomed Research International

Formulation strategies for bacteriophages to target intracellular bacterial pathogens

(2021) Wei Yan et al.   ADVANCED DRUG DELIVERY REVIEWS

Applications of bacteriophages against intracellular bacteria

(2021) Paulina Śliwka et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Mycobacteriophage–antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus

(2021) Matt D. Johansen et al.   Disease Models & Mechanisms

Characterization of a Broad-Host-Range Lytic Phage SHWT1 Against Multidrug-Resistant Salmonella and Evaluation of Its Therapeutic Efficacy in vitro and in vivo

(2021) Chenglin Tao et al.   Frontiers in Veterinary Science

Suboptimal drug exposure leads to selection of different subpopulations of ceftazidime-avibactam-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in a critically ill patient

(2021) Paolo Gaibani et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Endocytosis of Bacteriophages

(2021) Paulina Miernikiewicz et al.   Current Opinion in Virology

Nanotechnology Based Approaches in Phage Therapy: Overcoming the Pharmacological Barriers

(2021) Sandeep Kaur et al.   Frontiers in Pharmacology

Liver sinusoidal endothelial cells contribute to the uptake and degradation of entero bacterial viruses

(2020) Cristina I. Øie et al.   Scientific Reports

The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection

(2020) Yibing Xue et al.   Frontiers in Microbiology

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

Bacteriophage-Antibiotic Combination Strategy: An Alternative against Methicillin-resistant Phenotypes of Staphylococcus aureus

(2020) Razieh Kebriaei et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Exploring the Enzymatic and Antibacterial Activities of Novel Mycobacteriophage Lysin B Enzymes

(2020) Adel Abouhmad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacteriophage K1F targets Escherichia coli K1 in cerebral endothelial cells and influences the barrier function

(2020) Christian Møller-Olsen et al.   Scientific Reports

Examination of the Use of Bacteriophage as an Additive and Determining Its Best Application Method to Control Listeria monocytogenes in a Cooked-Meat Model System

(2020) Hanie Ahmadi et al.   Frontiers in Microbiology

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry

(2020) Carmen Gu Liu et al.   mBio

Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells

(2020) Alexandre Luscher et al.   Frontiers in Microbiology

Encapsulation and Delivery of Therapeutic Phages

(2020) Belinda Loh et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Enemy of My Enemy: New Insights Regarding Bacteriophage–Mammalian Cell Interactions

(2020) Katie Bodner et al.   TRENDS IN MICROBIOLOGY

Mycobacteriophage ZoeJ: A broad host-range close relative of mycobacteriophage TM4

(2019) Rebekah Dedrick et al.   TUBERCULOSIS

Fighting Pathogenic Bacteria on Two Fronts: Phages and Antibiotics as Combined Strategy

(2019) Thaysa Leite Tagliaferri et al.   Frontiers in Cellular and Infection Microbiology

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection

(2019) Johanna M. Sweere et al.   SCIENCE

Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages

(2019) Andrea Fulgione et al.   International Journal of Nanomedicine

Mycobacterium tuberculosis infection of host cells in space and time

(2019) Claudio Bussi et al.   FEMS MICROBIOLOGY REVIEWS

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Phage cocktail SalmoFREE® reduces Salmonella on a commercial broiler farm

(2019) V Clavijo et al.   POULTRY SCIENCE

Efficacy and potential of phage therapy against multidrug resistant Shigella spp.

(2019) Swee-Seong Tang et al.   PeerJ

The ΦCPG1 chlamydiaphage can infect Chlamydia trachomatis and significantly reduce its infectivity

(2019) Shijuan Wei et al.   VIRUS RESEARCH

Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema caused by Pseudomonas aeruginosa

(2019) Susan Maddocks et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Jeffrey D. Stanaway et al.   LANCET INFECTIOUS DISEASES

Phage therapy as a renewed therapeutic approach to mycobacterial infections: a comprehensive review

(2019) Taher Azimi et al.   Infection and Drug Resistance

Microencapsulation of Enteric Bacteriophages in a pH-Responsive Solid Oral Dosage Formulation Using a Scalable Membrane Emulsification Process

(2019) Vinner et al.   Pharmaceutics

Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy

(2019) Anca M Segall et al.   CURRENT OPINION IN MICROBIOLOGY

Phage therapy for severe bacterial infections: a narrative review

(2019) Aleksandra Petrovic Fabijan et al.   MEDICAL JOURNAL OF AUSTRALIA

The intracellular pathogen concept

(2019) Arturo Casadevall et al.   MOLECULAR MICROBIOLOGY

Yersinia Phages and Food Safety

(2019) Carlos G. Leon-Velarde et al.   Viruses-Basel

Evaluation of the Efficiency of Lytic Mycobacteriophage D29 on the Model of M. tuberculosis-Infected Macrophage RAW 264 Cell Line

(2018) M. B. Lapenkova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Microfluidic-assisted bacteriophage encapsulation into liposomes

(2018) Sharon S.Y. Leung et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Vibrio cholerae Outer Membrane Vesicles Inhibit Bacteriophage Infection

(2018) Tamara Reyes-Robles et al.   JOURNAL OF BACTERIOLOGY

Structural and functional stabilization of bacteriophage particles within the aqueous core of a W/O/W multiple emulsion: A potential biotherapeutic system for the inhalational treatment of bacterial pneumonia

(2018) Alessandra C. Rios et al.   PROCESS BIOCHEMISTRY

Liposome Entrapment of Bacteriophages Improves Wound Healing in a Diabetic Mouse MRSA Infection

(2018) Sanjay Chhibber et al.   Frontiers in Microbiology

Beyond Bacteria: Bacteriophage-Eukaryotic Host Interactions Reveal Emerging Paradigms of Health and Disease

(2018) Anushila Chatterjee et al.   Frontiers in Microbiology

Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens

(2018) Sonja Kunstmann et al.   Viruses-Basel

Nanoencapsulation of Bacteriophages in Liposomes Prepared Using Microfluidic Hydrodynamic Flow Focusing

(2018) Salvatore Cinquerrui et al.   Frontiers in Microbiology

Bacteriophage Therapy Testing against Shigella flexneri in a Novel Human Intestinal Organoid-Derived Infection Model

(2018) Alejandro Llanos-Chea et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Global, regional, and national burden of tuberculosis, 1990–2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study

(2018) Hmwe Hmwe Kyu et al.   LANCET INFECTIOUS DISEASES

Interactions between Bacteriophage, Bacteria, and the Mammalian Immune System

(2018) Jonas Van Belleghem et al.   Viruses-Basel

Engineered K1F bacteriophages kill intracellular Escherichia coli K1 in human epithelial cells

(2018) Christian Møller-Olsen et al.   Scientific Reports

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

(2017) Sunhee Lee et al.   Korean Journal for Food Science of Animal Resources

Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis

(2017) Lilliana Radoshevich et al.   NATURE REVIEWS MICROBIOLOGY

Anti-Tuberculosis Bacteriophage D29 Delivery with a Vibrating Mesh Nebulizer, Jet Nebulizer, and Soft Mist Inhaler

(2017) Nicholas B. Carrigy et al.   PHARMACEUTICAL RESEARCH

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers

(2017) Sophie Nguyen et al.   mBio

Internalization of a polysialic acid-binding Escherichia coli bacteriophage into eukaryotic neuroblastoma cells

(2017) Timo A. Lehti et al.   Nature Communications

A Novel Role of Listeria monocytogenes Membrane Vesicles in Inhibition of Autophagy and Cell Death

(2017) Svitlana Vdovikova et al.   Frontiers in Cellular and Infection Microbiology

Microfluidic Production of Multiple Emulsions

(2017) Goran Vladisavljević et al.   Micromachines

Synergy and Order Effects of Antibiotics and Phages in Killing Pseudomonas aeruginosa Biofilms

(2017) Waqas Nasir Chaudhry et al.   PLoS One

Study of intracellular Staphylococcus aureus control by virulent bacteriophage within MAC-T bovine mammary epithelial cells

(2016) Lili Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PhagesDB: the actinobacteriophage database

(2016) Daniel A Russell et al.   BIOINFORMATICS

Targeting the hard to reach: challenges and novel strategies in the treatment of intracellular bacterial infections

(2016) Nor Fadhilah Kamaruzzaman et al.   BRITISH JOURNAL OF PHARMACOLOGY

In vitro evaluation of a novel bacteriophage cocktail as a preventative for bovine coliform mastitis

(2016) J. Porter et al.   JOURNAL OF DAIRY SCIENCE

Bacteriophages with potential to inactivate Salmonella Typhimurium: Use of single phage suspensions and phage cocktails

(2016) Carla Pereira et al.   VIRUS RESEARCH

Trogocytosis-associated cell to cell spread of intracellular bacterial pathogens

(2016) Shaun Steele et al.   eLife

Intramacrophage Survival for Extracellular Bacterial Pathogens: MgtC As a Key Adaptive Factor

(2016) Claudine Belon et al.   Frontiers in Cellular and Infection Microbiology

Bacteriophage T4 Infection of Stationary Phase E. coli: Life after Log from a Phage Perspective

(2016) Daniel Bryan et al.   Frontiers in Microbiology

Encapsulation of Bacteriophage in Liposome Accentuates Its Entry in to Macrophage and Shields It from Neutralizing Antibodies

(2016) Saloni Singla et al.   PLoS One

Experimental Phage Therapy for Burkholderia pseudomallei Infection

(2016) Ong Guang-Han et al.   PLoS One

Phage selection restores antibiotic sensitivity in MDR Pseudomonas aeruginosa

(2016) Benjamin K. Chan et al.   Scientific Reports

Coxiella burnetii: turning hostility into a home

(2015) Jennifer H. Moffatt et al.   CELLULAR MICROBIOLOGY

A first step toward liposome-mediated intracellular bacteriophage therapy

(2015) Anita Nieth et al.   Expert Opinion on Drug Delivery

Bacterial Membrane Vesicles Mediate the Release ofMycobacterium tuberculosisLipoglycans and Lipoproteins from Infected Macrophages

(2015) Jaffre J. Athman et al.   JOURNAL OF IMMUNOLOGY

How bacterial pathogens colonize their hosts and invade deeper tissues

(2015) David Ribet et al.   MICROBES AND INFECTION

Outer-membrane vesicles from Gram-negative bacteria: biogenesis and functions

(2015) Carmen Schwechheimer et al.   NATURE REVIEWS MICROBIOLOGY

Mammalian Host-Versus-Phage immune response determines phage fate in vivo

(2015) Katarzyna Hodyra-Stefaniak et al.   Scientific Reports

Bacteriophage-aided intracellular killing of engulfed methicillin-resistant Staphylococcus aureus (MRSA) by murine macrophages

(2014) Sandeep Kaur et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhancement of the antimicrobial properties of bacteriophage-K via stabilization using oil-in-water nano-emulsions

(2014) Patricia Perez Esteban et al.   BIOTECHNOLOGY PROGRESS

Biomimetic aqueous-core lipid nanoballoons integrating a multiple emulsion formulation: A suitable housing system for viable lytic bacteriophages

(2014) Victor M. Balcão et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Titer dynamic analysis of D29 within MTB-infected macrophages and effect on immune function of macrophages

(2014) Xin Xiong et al.   EXPERIMENTAL LUNG RESEARCH

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Nanocarriers for antibiotics: A promising solution to treat intracellular bacterial infections

(2014) Nadia Abed et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

Probing the Endocytic Pathways of the Filamentous Bacteriophage in Live Cells Using Ratiometric pH Fluorescent Indicator

(2014) Ye Tian et al.   Advanced Healthcare Materials

Chlamydia bacteriophages

(2013) Joanna Śliwa-Dominiak et al.   ARCHIVES OF MICROBIOLOGY

Reprogramming Adult Schwann Cells to Stem Cell-like Cells by Leprosy Bacilli Promotes Dissemination of Infection

(2013) Toshihiro Masaki et al.   CELL

Significance of the Bacteriophage Treatment Schedule in Reducing Salmonella Colonization of Poultry

(2012) Carlota Bardina et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Autophagy and bacterial infectious diseases

(2012) Jae-Min Yuk et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Synergistic phage-antibiotic combinations for the control ofEscherichia colibiofilmsin vitro

(2012) Elizabeth M. Ryan et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

The in vivo extracellular life of facultative intracellular bacterial parasites: Role in pathogenesis

(2012) Manuel T. Silva et al.   IMMUNOBIOLOGY

Cellular Internalization Mechanism and Intracellular Trafficking of Filamentous M13 Phages Displaying a Cell-Penetrating Transbody and TAT Peptide

(2012) Aeyung Kim et al.   PLoS One

A composite bacteriophage alters colonization by an intestinal commensal bacterium

(2012) B. A. Duerkop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking the Transcriptional Profiles and the Physiological States of Mycobacterium tuberculosis during an Extended Intracellular Infection

(2012) Kyle H. Rohde et al.   PLoS Pathogens

Classical Labeling of Bacterial Pathogens According to Their Lifestyle in the Host: Inconsistencies and Alternatives

(2012) Manuel T. Silva   Frontiers in Microbiology

Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection

(2011) A. Khawaldeh et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Life on the Outside: The Rescue ofCoxiella burnetiifrom Its Host Cell

(2010) Anders Omsland et al.   Annual Review of Microbiology

Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment

(2009) V. Verma et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efficacy of Bacteriophage Therapy in a Model ofBurkholderia cenocepaciaPulmonary Infection

(2009) Lisa A. Carmody et al.   JOURNAL OF INFECTIOUS DISEASES

Life on the inside: the intracellular lifestyle of cytosolic bacteria

(2009) Katrina Ray et al.   NATURE REVIEWS MICROBIOLOGY

Host cell-free growth of the Q fever bacterium Coxiella burnetii

(2009) A. Omsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avoiding the void: cell-to-cell spread of human viruses

(2008) Quentin Sattentau   NATURE REVIEWS MICROBIOLOGY

Fc receptor-mediated, antibody-dependent enhancement of bacteriophage lambda-mediated gene transfer in mammalian cells

(2008) Ramil Sapinoro et al.   VIROLOGY

Proteasome inhibitors enhance bacteriophage lambda (λ) mediated gene transfer in mammalian cells

(2008) Ketna Volcy et al.   VIROLOGY