CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

Decoding the Phosphatase Code: Regulation of Cell Proliferation by Calcineurin

(2022) Takahiro Masaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

(2022) Weimin Yu et al.   Acta Pharmaceutica Sinica B

Substitution of SERCA2 Cys 674 accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis

(2022) Langtao Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts

(2022) Xiaoyang Huang et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA‑153 attenuates hypoxia‑induced excessive proliferation and migration of pulmonary arterial smooth muscle cells by targeting ROCK1 and NFATc3

(2021) Minjie Zhao et al.   Molecular Medicine Reports

Stimulation of Ca 2+ ‐ATPase Transport Activity by a Small‐Molecule Drug

(2021) Giacomo Sordi et al.   ChemMedChem

Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm

(2020) Yumei Que et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Role of TG2-Mediated SERCA2 Serotonylation on Hypoxic Pulmonary Vein Remodeling

(2020) Bo Liu et al.   Frontiers in Pharmacology

Smooth muscle NADPH oxidase 4 promotes angiotensin II-induced aortic aneurysm and atherosclerosis by regulating osteopontin

(2020) Weimin Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Osteopontin plays important roles in pulmonary arterial hypertension induced by systemic-to-pulmonary shunt

(2019) Liukun Meng et al.   FASEB JOURNAL

Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension

(2019) Marco Mura et al.   RESPIROLOGY

S1P induces pulmonary artery smooth muscle cell proliferation by activating calcineurin/NFAT/OPN signaling pathway

(2019) Xin Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SERCA control of cell death and survival

(2018) Elie R. Chemaly et al.   CELL CALCIUM

Role of Extracellular Matrix in the Pathogenesis of Pulmonary Arterial Hypertension

(2018) Thenappan Thenappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats

(2018) Rui-Lan He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player

(2016) G P Mognol et al.   Cell Death & Disease

Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders

(2015) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione Adducts on Sarcoplasmic/Endoplasmic Reticulum Ca2+ATPase Cys-674 Regulate Endothelial Cell Calcium Stores and Angiogenic Function as Well as Promote Ischemic Blood Flow Recovery

(2014) Melissa D. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice

(2013) Juan Manuel Ramiro-Diaz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension

(2013) Lahouaria Hadri et al.   CIRCULATION

Vascular smooth muscle cell phenotype is defined by Ca2+-dependent transcription factors

(2013) Olga Kudryavtseva et al.   FEBS Journal

Regulation of Ca2+Signaling in Pulmonary Hypertension

(2013) Amy L. Firth et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

NFATc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice

(2011) R. Bierer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sildenafil inhibits calcineurin/NFATc2-mediated cyclin A expression in pulmonary artery smooth muscle cells

(2011) Manxiang Li et al.   LIFE SCIENCES

Upregulation of Nox4 by TGFβ1 Oxidizes SERCA and Inhibits NO in Arterial Smooth Muscle of the Prediabetic Zucker Rat

(2010) XiaoYong Tong et al.   CIRCULATION RESEARCH

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY