4-Nitrochalcone as a potential drug in non-clinical breast cancer studies

Chalcones and Gastrointestinal Cancers: Experimental Evidence

(2023) Radka Michalkova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antitumor Effect of Chalcone Derivatives against Human Prostate (LNCaP and PC-3), Cervix HPV-Positive (HeLa) and Lymphocyte (Jurkat) Cell Lines and Their Effect on Macrophage Functions

(2023) Bruno Horta et al.   MOLECULES

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer

(2021) Yohei Saito et al.   MOLECULES

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

(2021) Bartolomeus J. Meijer et al.   Scientific Reports

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer

(2021) Chao Dong et al.   Frontiers in Pharmacology

Chalcone Derivatives: Role in Anticancer Therapy

(2021) Yang Ouyang et al.   Biomolecules

Chalcone Scaffolds, Bioprecursors of Flavonoids: Chemistry, Bioactivities, and Pharmacokinetics

(2021) Mithun Rudrapal et al.   MOLECULES

Imaging breast cancer using hyperpolarized carbon-13 MRI

(2020) Ferdia A. Gallagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic ERα and NFκB Promote Cell Survival in Mouse Mammary Cancer Cell Lines

(2020) Emily Smart et al.   Hormones & Cancer

Antitumor activity associated with hyperthermia and 4-nitrochalcone loaded in superparamagnetic poly(thioether-ester) nanoparticles

(2020) Paula Christina Mattos dos Santos et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity

(2020) João Paulo Assolini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

In vitro synergic activity of diethyldithiocarbamate and 4-nitrochalcone loaded in beeswax nanoparticles against melanoma (B16F10) cells

(2020) Arthur Poester Cordeiro et al.   Materials Science & Engineering C-Materials for Biological Applications

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

(2020) Niklas Gremke et al.   Nature Communications

The Double-Edge Sword of Autophagy in Cancer: From Tumor Suppression to Pro-tumor Activity

(2020) Rodolfo Chavez-Dominguez et al.   Frontiers in Oncology

The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state

(2020) Simei Go et al.   APOPTOSIS

Synthesis, Molecular Docking and Biological Activity Evaluation of Alkoxy Substituted Chalcone Derivatives: Potential Apoptosis Inducing Agent on MCF-7 Cells

(2020) Wan M. Khairul et al.   Anti-Cancer Agents in Medicinal Chemistry

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations

(2019) Cedric Magaway et al.   Cells

Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy

(2018) Sneha Mishra et al.   Scientific Reports

Glycolysis inhibition via mTOR suppression is a key step in cardamonin-induced autophagy in SKOV3 cells

(2018) Daohua Shi et al.   BMC Complementary and Alternative Medicine

New quinoline/chalcone hybrids as anti-cancer agents: Design, synthesis, and evaluations of cytotoxicity and PI3K inhibitory activity

(2018) Samar H. Abbas et al.   BIOORGANIC CHEMISTRY

Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats

(2017) Carlos Eduardo Alves de Souza et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth

(2017) Hsin-Yuan Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells

(2016) Zahoor Ahmad Wani et al.   FOOD AND CHEMICAL TOXICOLOGY

BIOLOGICAL ACTIVITIES AND NOVEL APPLICATIONS OF CHALCONES

(2016) C. DÍAZ-TIELAS et al.   Planta Daninha

BIOLOGICAL ACTIVITIES AND NOVEL APPLICATIONS OF CHALCONES

(2016) C. DÍAZ-TIELAS et al.   Planta Daninha

Design and Discovery of Some Novel Chalcones as Antioxidant and Anti-Inflammatory Agents via Attenuating NF-κB

(2015) Jun Chu et al.   ARCHIV DER PHARMAZIE

Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism

(2014) Peter Kovacic et al.   JOURNAL OF APPLIED TOXICOLOGY

Catabolism of Exogenous Lactate Reveals It as a Legitimate Metabolic Substrate in Breast Cancer

(2013) Kelly M. Kennedy et al.   PLoS One

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death

(2013) P K Singha et al.   Cell Death & Disease

Cytoplasmic Estrogen Receptor in Breast Cancer

(2011) A. W. Welsh et al.   CLINICAL CANCER RESEARCH

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hyperbolastic modeling of tumor growth with a combined treatment of iodoacetate and dimethylsulphoxide

(2010) Wayne M Eby et al.   BMC CANCER

Estrogen-Dependent and Estrogen-Independent Mechanisms Contribute to AIB1-Mediated Tumor Formation

(2010) M. I. Torres-Arzayus et al.   CANCER RESEARCH

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

A novel role for MAP1 LC3 in nonautophagic cytoplasmic vacuolation death of cancer cells

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