TGFβ1-driven SMAD2/3 phosphorylation and myofibroblast emergence are fully dependent on the TGFβ1 pre-activation of MAPKs and controlled by maternal leucine zipper kinase

Myofibroblasts: Function, Formation, and Scope of Molecular Therapies for Skin Fibrosis

(2021) Yifan Tai et al.   Biomolecules

TGFβ1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial–mesenchymal transition in Sjögren’s syndrome

(2020) Margherita Sisto et al.   LABORATORY INVESTIGATION

Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies

(2020) Danielle Kamato et al.   BIOMEDICINE & PHARMACOTHERAPY

Corneal myofibroblasts and fibrosis

(2020) Steven E. Wilson   EXPERIMENTAL EYE RESEARCH

Non-canonical (non-SMAD2/3) TGF-β signaling in fibrosis: Mechanisms and targets

(2019) Kenneth W. Finnson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Post-Translational Modifications of the TAK1-TAB Complex

(2017) Yusuke Hirata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure

(2017) Marion Lanier et al.   ACS Medicinal Chemistry Letters

The corneal fibrosis response to epithelial–stromal injury

(2016) Andre A.M. Torricelli et al.   EXPERIMENTAL EYE RESEARCH

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight

(2016) B. Barry Touré et al.   JOURNAL OF MEDICINAL CHEMISTRY

The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research

(2015) Manoj B Menon et al.   Autophagy

Designing New Kinase Inhibitor Derivatives as Therapeutics Against Common Complex Diseases: Structural Basis of Microtubule Affinity-Regulating Kinase 4 (MARK4) Inhibition

(2015) Farha Naz et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer

(2015) Suyoun Chung et al.   Oncotarget

Transforming Growth Factor (TGF)-β-activated Kinase 1 (TAK1) Activation Requires Phosphorylation of Serine 412 by Protein Kinase A Catalytic Subunit α (PKACα) and X-linked Protein Kinase (PRKX)

(2014) Chuan Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII Activates ASK1 to Induce Apoptosis of Spinal Astrocytes Under Oxygen–Glucose Deprivation

(2013) Gang Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Maternal Embryonic Leucine Zipper Kinase (MELK): A Novel Regulator in Cell Cycle Control, Embryonic Development, and Cancer

(2013) Pengfei Jiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-I B Kinase Cascade

(2013) M. C. Puckett et al.   MOLECULAR AND CELLULAR BIOLOGY

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors

(2012) Yoshito Terao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Key role for ubiquitin protein modification in TGFβ signal transduction

(2012) Miriam De Boeck et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

MAP Kinase Pathways

(2012) D. K. Morrison   Cold Spring Harbor Perspectives in Biology

Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190

(2011) Naval P. Shanware et al.   BMB Reports

TGF-β signaling in fibrosis

(2011) Anna Biernacka et al.   GROWTH FACTORS

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

(2011) John P. Duffy et al.   ACS Medicinal Chemistry Letters

A novel glycosylation signal regulates transforming growth factor   receptors as evidenced by endo- -galactosidase C expression in rodent cells

(2010) S. Watanabe et al.   GLYCOBIOLOGY

Noncanonical transforming growth factor β signaling in scleroderma fibrosis

(2009) Maria Trojanowska   CURRENT OPINION IN RHEUMATOLOGY

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

(2009) J J Gu et al.   ONCOGENE

Murine Protein Serine/Threonine Kinase 38 Activates Apoptosis Signal-regulating Kinase 1 via Thr838Phosphorylation

(2008) Haiyoung Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression

(2008) Yang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Corneal crystallins and the development of cellular transparency

(2007) James V. Jester   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY