Key role for ubiquitin protein modification in TGFβ signal transduction

Non-Smad signaling pathways

(2011) Yabing Mu et al.   CELL AND TISSUE RESEARCH

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

(2011) Y-H Fan et al.   CELL DEATH AND DIFFERENTIATION

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

(2011) Maoyuan Tian et al.   FEBS LETTERS

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor β (TGF-β) Signaling and the Development of Regulatory T Cells

(2011) Yongge Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of the Negative Regulation of Smad1/5 Protein by Carboxyl Terminus of Hsc70-interacting Protein (CHIP)

(2011) Le Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pivotal Role of the C2 Domain of the Smurf1 Ubiquitin Ligase in Substrate Selection

(2011) Kefeng Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity

(2011) Daizo Koinuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD109-mediated degradation of TGF-β receptors and inhibition of TGF-β responses involve regulation of SMAD7 and Smurf2 localization and function

(2011) Albane A. Bizet et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Recruitment of TIF1γ to Chromatin via Its PHD Finger-Bromodomain Activates Its Ubiquitin Ligase and Transcriptional Repressor Activities

(2011) Eleonora Agricola et al.   MOLECULAR CELL

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

(2011) Masafumi Inui et al.   NATURE CELL BIOLOGY

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of E3 Ligase Smurf1 Switches Its Substrate Preference in Support of Axon Development

(2011) Pei-lin Cheng et al.   NEURON

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT

(2011) S M Soond et al.   ONCOGENE

SMURF1 Amplification Promotes Invasiveness in Pancreatic Cancer

(2011) Kevin A. Kwei et al.   PLoS One

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

(2011) Yabing Mu et al.   Nature Communications

Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling

(2011) Youn Sook Lee et al.   Nature Communications

Identification of Substrates of SMURF1 Ubiquitin Ligase Activity Utilizing Protein Microarrays

(2010) Paul S. Andrews et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Negative control of Smad activity by ectodermin/Tif1  patterns the mammalian embryo

(2010) L. Morsut et al.   DEVELOPMENT

Early phase TGFβ receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses

(2010) Anthony J. Cutts et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Reduction of transforming growth factor-β type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma

(2010) Hirotaka Fukasawa et al.   INTERNATIONAL JOURNAL OF CANCER

Estrogen Inhibits Transforming Growth Factor β Signaling by Promoting Smad2/3 Degradation

(2010) Ichiaki Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Krüppel-like Factor 4 by the Anaphase Promoting Complex Pathway Is Involved in TGF-β Signaling

(2010) Dong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T RI/Alk5-independent T RII signaling to ERK1/2 in human skin cells according to distinct levels of T RII expression

(2010) B. Bandyopadhyay et al.   JOURNAL OF CELL SCIENCE

Cbl-b-/- T Cells Demonstrate In Vivo Resistance to Regulatory T Cells but a Context-Dependent Resistance to TGF- 

(2010) C. O. Adams et al.   JOURNAL OF IMMUNOLOGY

Tumor suppressor Fbxw7 regulates TGFβ signaling by targeting TGIF1 for degradation

(2010) M T Bengoechea-Alonso et al.   ONCOGENE

Transcription alterations of members of the ubiquitin–proteasome network in prostate carcinoma

(2010) O J C Hellwinkel et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases

(2009) Masahiro Narimatsu et al.   CELL

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells

(2009) Yoshiko Nagano et al.   JOURNAL OF BIOCHEMISTRY

Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins

(2009) Ayako Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation

(2009) Shan Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Tumor Necrosis Factor-Receptor–associated Factor-4 Is a Positive Regulator of Transforming Growth Factor-β Signaling That Affects Neural Crest Formation

(2009) Tuzer Kalkan et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation

(2008) Isabelle Carpentier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes

(2008) Bei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Ski co-repressor complexes maintain the basal repressed state of the TGF-β target gene,SMAD7, via HDAC3 and PRMT5

(2008) Takanori Tabata et al.   GENES TO CELLS

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

(2008) Yusuke Sato et al.   NATURE

The type I TGF-β receptor is covalently modified and regulated by sumoylation

(2008) Jong Seok Kang et al.   NATURE CELL BIOLOGY

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY