Head-to-Head Comparison of CCN4, DNMT3A, PTPN11, and SPARC as Suppressors of Anti-tumor Immunity

Cell Communication Network factor 4 promotes tumor‐induced immunosuppression in melanoma

(2022) Audry Fernandez et al.   EMBO REPORTS

Data-driven learning how oncogenic gene expression locally alters heterocellular networks

(2022) David J. Klinke et al.   Nature Communications

A single-cell and spatially resolved atlas of human breast cancers

(2021) Sunny Z. Wu et al.   NATURE GENETICS

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer

(2020) Sara Moufarrij et al.   Scientific Reports

Interleukin-12 elicits a non-canonical response in B16 melanoma cells to enhance survival

(2020) Christina N. Byrne-Hoffman et al.   Cell Communication and Signaling

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

(2020) Weiwei Tao et al.   Nature Communications

WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial - mesenchymal transition

(2019) Wentao Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tumor cell‐secreted matricellular protein WISP 1 drives pro‐metastatic collagen linearization

(2019) Hong Jia et al.   EMBO JOURNAL

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression

(2019) Cristina Segovia et al.   NATURE MEDICINE

Cell Communication Network Factor 4 (CCN4/WISP1) Shifts Melanoma Cells from a Fragile Proliferative State to a Resilient Metastatic State

(2019) Wentao Deng et al.   Cellular and Molecular Bioengineering

Communication between EMT and PD-L1 signaling: New insights into tumor immune evasion

(2019) Yuanyuan Jiang et al.   CANCER LETTERS

A genome-scale CRISPR/Cas9 knockout screening reveals SH3D21 as a sensitizer for gemcitabine

(2019) Mohammad Masoudi et al.   Scientific Reports

Exosomes derived from B16F0 melanoma cells alter the transcriptome of cytotoxic T cells that impacts mitochondrial respiration

(2018) Cassidy L. Bland et al.   FEBS Journal

CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via α5β1 and TNFα

(2018) Mitsuaki Ono et al.   MATRIX BIOLOGY

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

(2018) Livnat Jerby-Arnon et al.   CELL

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

PTPN11 Plays Oncogenic Roles and Is a Therapeutic Target for BRAF Wild-Type Melanomas

(2018) Kristen S. Hill et al.   MOLECULAR CANCER RESEARCH

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

Melanoma exosomes deliver a complex biological payload that upregulates PTPN11 to suppress T lymphocyte function

(2017) Yueting Wu et al.   Pigment Cell & Melanoma Research

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

(2016) I. Tirosh et al.   SCIENCE

In silico model-based inference: A contemporary approach for hypothesis testing in network biology

(2014) David J. Klinke   BIOTECHNOLOGY PROGRESS

The de novo DNA methyltransferase DNMT3A in development and cancer

(2014) Bi-Feng Chen et al.   Epigenetics

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

(2013) Chun-Han Hou et al.   ARTHRITIS RESEARCH & THERAPY

A quantitative systems approach to identify paracrine mechanisms that locally suppress immune response to Interleukin-12 in the B16 melanoma model

(2012) Yogesh M. Kulkarni et al.   Integrative Biology

SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis

(2011) María R. Girotti et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An essential role for DNA methyltransferase 3a in melanoma tumorigenesis

(2009) Tao Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS