A 3D Human Lymphatic Vessel-on-Chip Reveals the Roles of Interstitial Flow and VEGF-A/C for Lymphatic Sprouting and Discontinuous Junction Formation

Buttons and Zippers: Endothelial Junctions in Lymphatic Vessels

(2022) Peter Baluk et al.   Cold Spring Harbor Perspectives in Medicine

A Microfluidic Model of AQP4 Polarization Dynamics and Fluid Transport in the Healthy and Inflamed Human Brain: The First Step Towards Glymphatics‐on‐a‐Chip

(2022) Paul A. Soden et al.   Advanced Biology

Modeling Immunity In Vitro: Slices, Chips, and Engineered Tissues

(2021) Jennifer H. Hammel et al.   Annual Review of Biomedical Engineering

Biology of Lymphedema

(2021) Bianca Brix et al.   Biology-Basel

Long-Lived Human Lymphatic Endothelial Cells to Study Lymphatic Biology and Lymphatic Vessel/Tumor Coculture in a 3D Microfluidic Model

(2021) Nicola Frenkel et al.   ACS Biomaterials-Science & Engineering

A bioengineered lymphatic vessel model for studying lymphatic endothelial cell‐cell junction and barrier function

(2021) Aria R. Henderson et al.   MICROCIRCULATION

Human Tumor‐Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells

(2020) Jose M. Ayuso et al.   Advanced Healthcare Materials

Lymphatic Endothelial Cell Junctions: Molecular Regulation in Physiology and Diseases

(2020) Feng Zhang et al.   Frontiers in Physiology

The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

(2020) Guillermo Oliver et al.   CELL

Biological functions of lymphatic vessels

(2020) Tatiana V. Petrova et al.   SCIENCE

Robust 2D Otsu’s Algorithm for Uneven Illumination Image Segmentation

(2020) Jiangwa Xing et al.   Computational Intelligence and Neuroscience

The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model

(2020) Subhashree Kumaravel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Rapid multilayer microfabrication for modeling organotropic metastasis in breast cancer

(2020) Tae Joon Kwak et al.   Biofabrication

Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi

(2020) Seon Pyo Hong et al.   Nature Communications

In vitro modeling of solid tumor interactions with perfused blood vessels

(2020) Tae Joon Kwak et al.   Scientific Reports

Evaluation of a 3D human artificial lymph node as test model for the assessment of immunogenicity of protein aggregates

(2019) Teresa Kraus et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Tumor‐on‐a‐Chip System with Bioprinted Blood and Lymphatic Vessel Pair

(2019) Xia Cao et al.   ADVANCED FUNCTIONAL MATERIALS

Human organotypic lymphatic vessel model elucidates microenvironment-dependent signaling and barrier function

(2019) Max M. Gong et al.   BIOMATERIALS

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

(2019) Duc-Huy T. Nguyen et al.   Science Advances

Lymphatic System Flows

(2018) James E. Moore et al.   Annual Review of Fluid Mechanics

Dendritic cells, T cells and lymphatics: dialogues in migration and beyond

(2018) Marc Permanyer et al.   CURRENT OPINION IN IMMUNOLOGY

Apigenin and Luteolin Attenuate the Breaching of MDA-MB231 Breast Cancer Spheroids Through the Lymph Endothelial Barrier in Vitro

(2018) Junli Hong et al.   Frontiers in Pharmacology

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease

(2018) Sandro Da Mesquita et al.   NATURE

Lacteal junction zippering protects against diet-induced obesity

(2018) Feng Zhang et al.   SCIENCE

Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development

(2018) Jennifer Bourland et al.   Scientific Reports

Multiple roles of lymphatic vessels in peripheral lymph node development

(2018) Esther Bovay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Laminar flow downregulates Notch activity to promote lymphatic sprouting

(2017) Dongwon Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis

(2017) Laure Gibot et al.   Nature Protocols

Three-dimensional biomimetic model to reconstitute sprouting lymphangiogenesis in vitro

(2016) Sudong Kim et al.   BIOMATERIALS

Cell-based approach for 3D reconstruction of lymphatic capillaries in vitro reveals distinct functions of HGF and VEGF-C in lymphangiogenesis

(2016) Laure Gibot et al.   BIOMATERIALS

Lymphatic System in Cardiovascular Medicine

(2016) Aleksanteri Aspelund et al.   CIRCULATION RESEARCH

An in vitro model of the tumor–lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion

(2015) M. Pisano et al.   Integrative Biology

Intravital imaging of intestinal lacteals unveils lipid drainage through contractility

(2015) Kibaek Choe et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymph flow regulates collecting lymphatic vessel maturation in vivo

(2015) Daniel T. Sweet et al.   JOURNAL OF CLINICAL INVESTIGATION

Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells

(2015) Emma L. Kuan et al.   JOURNAL OF IMMUNOLOGY

Lymphangiogenic factors, mechanisms, and applications

(2014) Wei Zheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Lymphedema and Obesity

(2014) Babak J. Mehrara et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Deconstructing Dimensionality

(2013) M. A. Schwartz et al.   SCIENCE

Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation

(2012) Li-Chin Yao et al.   AMERICAN JOURNAL OF PATHOLOGY

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

(2011) W. Zheng et al.   BLOOD

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

(2011) Michael T. Dellinger et al.   PLoS One

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Organization and developmental aspects of lymphatic vessels

(2008) Osamu Ohtani et al.   ARCHIVES OF HISTOLOGY AND CYTOLOGY

Transcriptional profiling of VEGF-A and VEGF-C target genes in lymphatic endothelium reveals endothelial-specific molecule-1 as a novel mediator of lymphangiogenesis

(2008) J. W. Shin et al.   BLOOD

Modeling lymphangiogenesis in a three-dimensional culture system

(2008) Françoise Bruyère et al.   NATURE METHODS