The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans

Compromised hepatic mitochondrial fatty acid oxidation and reduced markers of mitochondrial turnover in human NAFLD

(2022) Mary P. Moore et al.   HEPATOLOGY

Inhibition of carnitine palmitoyl-transferase 1A in hepatic stellate cells protects against fibrosis

(2022) Marcos F. Fondevila et al.   JOURNAL OF HEPATOLOGY

Ethnic and gender differences in hepatic lipid content and related cardiometabolic parameters in lean individuals

(2022) Kitt Falk Petersen et al.   JCI Insight

Bdh1 overexpression ameliorates hepatic injury by activation of Nrf2 in a MAFLD mouse model

(2022) Bu-tuo Xu et al.   Cell Death Discovery

Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

(2021) Rohit Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome-Wide Association Study on Alanine Aminotransferase Identifies Sequence Variants in the GPAM and APOE Associated With Fatty Liver Disease

(2021) Oveis Jamialahmadi et al.   GASTROENTEROLOGY

Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH

(2021) Leigh Goedeke et al.   Molecular Metabolism

Mechanisms and disease consequences of nonalcoholic fatty liver disease

(2021) Rohit Loomba et al.   CELL

TVB-2640 (FASN Inhibitor) for the Treatment of Nonalcoholic Steatohepatitis: FASCINATE-1, a Randomized, Placebo-Controlled Phase 2a Trial

(2021) Rohit Loomba et al.   GASTROENTEROLOGY

Hepatic CPT1A Facilitates Liver–Adipose Cross Talk via Induction of FGF21 in Mice

(2021) Wei Sun et al.   DIABETES

Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease

(2021) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease

(2020) Stefano Romeo et al.   Cell Metabolism

Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis

(2020) Björn Carlsson et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

(2020) Panu K. Luukkonen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

(2020) Kasper W. ter Horst et al.   DIABETES CARE

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

PNPLA3, CGI-58, and Inhibition of Hepatic Triglyceride Hydrolysis in Mice

(2019) Yang Wang et al.   HEPATOLOGY

Past, present and future perspectives in nonalcoholic fatty liver disease

(2019) Arun J. Sanyal   Nature Reviews Gastroenterology & Hepatology

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

(2019) Soumik BasuRay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

(2019) Naim Alkhouri et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

(2019) Kitt Falk Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

(2019) Leanne Hodson et al.   Nature Reviews Endocrinology

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2019) Stephen A Harrison et al.   LANCET

Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease

(2019) Gordon I. Smith et al.   JOURNAL OF CLINICAL INVESTIGATION

Patatin-like phospholipase domain–containing protein 3 promotes transfers of essential fatty acids from triglycerides to phospholipids in hepatic lipid droplets

(2018) Matthew A. Mitsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

(2016) Panu K. Luukkonen et al.   JOURNAL OF HEPATOLOGY

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due toPNPLA3Sequence Variant

(2015) Rosellina M. Mancina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased De Novo Lipogenesis Is a Distinct Characteristic of Individuals With Nonalcoholic Fatty Liver Disease

(2013) Jennifer E. Lambert et al.   GASTROENTEROLOGY

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

(2012) Ksenia Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

(2012) Jarkko Soronen et al.   BMC Medical Genomics

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

(2011) K. Sevastianova et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease

(2010) Luca Valenti et al.   HEPATOLOGY

A feed-forward loop amplifies nutritional regulation of PNPLA3

(2010) Yongcheng Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS