USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A

A pan-cancer analysis of molecular characteristics and oncogenic role of gasdermins

(2022) Mingchao Mu et al.   Cancer Cell International

Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients

(2022) Ori Hassin et al.   Nature Communications

Screening for Colorectal Cancer

(2021) Jennifer S. Lin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

(2021) Xun Shangguan et al.   Nature Communications

SENP1 participates in Irinotecan resistance in human colon cancer cells

(2021) Ming‐Cheng Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling

(2021) Eui Jung Moon et al.   Nature Communications

JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles

(2021) Jaime A Castro-Mondragon et al.   NUCLEIC ACIDS RESEARCH

Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization

(2021) Zhiyong Xu et al.   Nature Communications

Interferon, restriction factors and SUMO pathways

(2020) Faten El-Asmi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome

(2020) Tatsuo Miyamoto et al.   EMBO JOURNAL

HIF-transcribed p53 chaperones HIF-1α

(2019) Esha Madan et al.   NUCLEIC ACIDS RESEARCH

USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation

(2019) Sunbin Ling et al.   GUT

Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer

(2018) Yen-An Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SUMO protease SENP1 deSUMOylates and stabilizes c-Myc

(2018) Xiao-Xin Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

(2017) Chun-Ping Cui et al.   GUT

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

(2016) Zhiquan Wang et al.   GENES & DEVELOPMENT

JASSA: a comprehensive tool for prediction of SUMOylation sites and SIMs

(2015) Guillaume Beauclair et al.   BIOINFORMATICS

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

(2015) Dingzhi Wang et al.   GASTROENTEROLOGY

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1

(2014) Peijing Zhang et al.   NATURE CELL BIOLOGY

Chemotherapeutic Sensitivity of Testicular Germ Cell Tumors Under Hypoxic Conditions Is Negatively Regulated by SENP1-Controlled Sumoylation of OCT4

(2012) Y.-C. Wu et al.   CANCER RESEARCH

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

(2010) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

Expression of HIF-1alpha and VEGF in colorectal cancer: association with clinical outcomes and prognostic implications

(2009) Dan Cao et al.   BMC CANCER

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

(2008) Edward T. H. Yeh   JOURNAL OF BIOLOGICAL CHEMISTRY