Fibroblast inhibition by tocilizumab enabled gemcitabine/nab‐paclitaxel rechallenge for pancreatic cancer

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

(2022) Hidetaka Suzuki et al.   Cancer Medicine

Clinical Practice Guidelines for Pancreatic Cancer 2019 From the Japan Pancreas Society

(2020) Takuji Okusaka et al.   PANCREAS

Low-dose nab-paclitaxel-based combination chemotherapy in heavily pretreated pancreatic cancer patients

(2019) Shih-Hung Yang et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies

(2018) Herbert Hurwitz et al.   INVESTIGATIONAL NEW DRUGS

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

A Phase Ib study of ruxolitinib + gemcitabine ± nab-paclitaxel in patients with advanced solid tumors

(2018) Todd Bauer et al.   OncoTargets and Therapy

Angiogenesis in pancreatic cancer: current research status and clinical implications

(2018) Shuo Li et al.   ANGIOGENESIS

Loss of P53 Function Activates JAK2–STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival

(2016) Sonja M. Wörmann et al.   GASTROENTEROLOGY

C-Reactive Protein Level Is an Indicator of the Aggressiveness of Advanced Pancreatic Cancer

(2016) Shuichi Mitsunaga et al.   PANCREAS

Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer

(2015) S. Takeuchi et al.   CANCER RESEARCH

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed

(2015) Herbert I. Hurwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Binding of C/EBP  to the C-Reactive Protein (CRP) Promoter in Hep3B Cells Is Associated with Transcription of CRP mRNA

(2014) D. P. Young et al.   JOURNAL OF IMMUNOLOGY

Transcriptional Complex Formation of c-Fos, STAT3, and Hepatocyte NF-1  Is Essential for Cytokine-Driven C-Reactive Protein Gene Expression

(2014) T. Nishikawa et al.   JOURNAL OF IMMUNOLOGY

Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer

(2013) S Mitsunaga et al.   BRITISH JOURNAL OF CANCER

Pancreatic Cancer-Associated Stellate Cells Promote Differentiation of Myeloid-Derived Suppressor Cells in a STAT3-Dependent Manner

(2013) T. A. Mace et al.   CANCER RESEARCH

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

Fibroblasts associated with cancer cells keep enhanced migration activity after separation from cancer cells: A novel character of tumor educated fibroblasts

(2010) Ishii   INTERNATIONAL JOURNAL OF ONCOLOGY

Fibrinogen induces cytokine and collagen production in pancreatic stellate cells

(2008) A Masamune et al.   GUT

Assessment of Apoptosis by Immunohistochemistry to Active Caspase-3, Active Caspase-7, or Cleaved PARP in Monolayer Cells and Spheroid and Subcutaneous Xenografts of Human Carcinoma

(2008) Aude Bressenot et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY