Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring

(2019) Yu Shi et al.   NATURE

Neural Invasion Spreads Macrophage-Related Allodynia via Neural Root in Pancreatic Cancer

(2018) Tomofumi Miura et al.   ANESTHESIA AND ANALGESIA

IL-6 mediates cross-talk between activated fibroblasts and tumor cells in the tumor microenvironment

(2018) Tatiana A Karakasheva et al.   CANCER RESEARCH

Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

(2018) Gina L. Razidlo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of C-Reactive Protein at Sites of Inflammation and Infection

(2018) Nicola R. Sproston et al.   Frontiers in Immunology

Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts

(2017) Yasufumi Nishikawa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tocilizumab (Actemra)

(2017) Martin Sheppard et al.   Human Vaccines & Immunotherapeutics

Cytokines in cerebrospinal fluid of neurosyphilis patients: Identification of Urokinase plasminogen activator using antibody microarrays

(2016) Ping Lu et al.   JOURNAL OF NEUROIMMUNOLOGY

C-Reactive Protein Level Is an Indicator of the Aggressiveness of Advanced Pancreatic Cancer

(2016) Shuichi Mitsunaga et al.   PANCREAS

Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells

(2016) Nagaraj S. Nagathihalli et al.   Oncotarget

Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain–immune interface

(2016) Sanae Hasegawa-Ishii et al.   Scientific Reports

Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR−/HER2+breast cancers

(2015) Ruth Rodriguez-Barrueco et al.   GENES & DEVELOPMENT

Randomized, Double-Blind, Phase II Study of Ruxolitinib or Placebo in Combination With Capecitabine in Patients With Metastatic Pancreatic Cancer for Whom Therapy With Gemcitabine Has Failed

(2015) Herbert I. Hurwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

Ruxolitinib versus Standard Therapy for the Treatment of Polycythemia Vera

(2015) Alessandro M. Vannucchi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR

(2015) Ulrike M. Litzenburger et al.   Oncotarget

Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis

(2013) F. Cervantes et al.   BLOOD

Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT3 Signaling

(2013) K. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Control of gp130 expression by the mitogen-activated protein kinase ERK2

(2013) N A Bonito et al.   ONCOGENE

Impact of tumor-associated macrophages on invasive ductal carcinoma of the pancreas head

(2012) Kiyoshi Yoshikawa et al.   CANCER SCIENCE

Neural invasion induces cachexiaviaastrocytic activation of neural route in pancreatic cancer

(2012) Akira Imoto et al.   INTERNATIONAL JOURNAL OF CANCER

Nerve invasion distance is dependent on laminin γ2 in tumors of pancreatic cancer

(2009) Shuichi Mitsunaga et al.   INTERNATIONAL JOURNAL OF CANCER

Low Serum Level of Cholinesterase at Recurrence of Pancreatic Cancer Is a Poor Prognostic Factor and Relates to Systemic Disorder and Nerve Plexus Invasion

(2009) Shuichi Mitsunaga et al.   PANCREAS

Pancreatic Neuropathy and Neuropathic Pain—A Comprehensive Pathomorphological Study of 546 Cases

(2008) Güralp O. Ceyhan et al.   GASTROENTEROLOGY