STING activation counters glioblastoma by vascular alteration and immune surveillance

STING agonism turns human T cells into interferon‐producing cells but impedes their functionality

(2023) Niklas Kuhl et al.   EMBO REPORTS

Reelin cells and sex‐dependent synaptopathology in autism following postnatal immune activation

(2022) Maryam Ardalan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition

(2022) Justin T. Low et al.   CANCER CELL

STING activation promotes robust immune response and NK cell–mediated tumor regression in glioblastoma models

(2022) Gilles Berger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9

(2021) Martin F. Berthelsen et al.   Cancers

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

(2021) Su Chul Jang et al.   Communications Biology

STING Agonists as Cancer Therapeutics

(2021) Afsaneh Amouzegar et al.   Cancers

Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis

(2021) Motaz Hamed et al.   Frontiers in Oncology

Long-term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open-label, multicentre, phase 2 study

(2021) Hussein A Tawbi et al.   LANCET ONCOLOGY

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

(2020) David A. Reardon et al.   JAMA Oncology

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

(2020) Tania Løve Aaes et al.   CELL DEATH AND DIFFERENTIATION

Modulation of temozolomide dose differentially affects T-cell response to immune checkpoint inhibition

(2019) Aida Karachi et al.   NEURO-ONCOLOGY

Nivolumab and brain metastases in patients with advanced non-squamous non-small cell lung cancer

(2019) Lucio Crinò et al.   LUNG CANCER

Adverse Event Profiles of Anti-CTLA-4 and Anti-PD-1 Monoclonal Antibodies Alone or in Combination: Analysis of Spontaneous Reports Submitted to FAERS

(2019) Huan-huan Ji et al.   CLINICAL DRUG INVESTIGATION

Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study

(2019) Edward B. Garon et al.   JOURNAL OF CLINICAL ONCOLOGY

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

(2019) Hannah Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

(2019) Martin K. Thomsen et al.   ONCOGENE

STING agonists enable antiviral cross-talk between human cells and confer protection against genital herpes in mice

(2018) Morten K. Skouboe et al.   PLoS Pathogens

Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy: a comprehensive review of registration trials and future considerations

(2018) Jun Gong et al.   Journal for ImmunoTherapy of Cancer

Type 1 IFN and PD-L1 Coordinate Lymphatic Endothelial Cell Expansion and Contraction during an Inflammatory Immune Response

(2018) Erin D. Lucas et al.   JOURNAL OF IMMUNOLOGY

Combined Nivolumab and Ipilimumab in Melanoma Metastatic to the Brain

(2018) Hussein A. Tawbi et al.   NEW ENGLAND JOURNAL OF MEDICINE

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

(2017) Ryan D Chow et al.   NATURE NEUROSCIENCE

CNS cancer: Glioblastoma subtypes revisited

(2017) Peter Sidaway   Nature Reviews Clinical Oncology

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: results from exploratory phase I cohorts of CheckMate 143

(2017) Antonio Omuro et al.   NEURO-ONCOLOGY

Lomustine and Bevacizumab in Progressive Glioblastoma

(2017) Wolfgang Wick et al.   NEW ENGLAND JOURNAL OF MEDICINE

White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging

(2017) Brian Hansen et al.   NMR IN BIOMEDICINE

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

(2015) Olivier Demaria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The STING pathway and the T cell-inflamed tumor microenvironment

(2015) Seng-Ryong Woo et al.   TRENDS IN IMMUNOLOGY

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model

(2015) D. A. Reardon et al.   Cancer Immunology Research

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma

(2014) Olivier L. Chinot et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Diffusion-Weighted MRI and Quantitative Biophysical Modeling of Hippocampal Neurite Loss in Chronic Stress

(2011) Peter Vestergaard-Poulsen et al.   PLoS One

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE