Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts

Celastrol in cancer therapy: Recent developments, challenges and prospects

(2021) Hannah Ying Lim et al.   CANCER LETTERS

Glucose transporter 1 (GLUT1)-targeting and hypoxia-activated mitochondria-specific chemo-thermal therapy via a glycosylated poly(amido amine)/celastrol (PAMAM/Cel) complex

(2021) Guijie Wei et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Tumor microenvironment (TME)-activatable circular aptamer-PEG as an effective hierarchical-targeting molecular medicine for photodynamic therapy

(2020) Yu Yang et al.   BIOMATERIALS

Bortezomib Dendrimer Prodrug-Based Nanoparticle System

(2019) Xuefeng Hu et al.   ADVANCED FUNCTIONAL MATERIALS

Single-Cell-Derived Tumor-Sphere Formation and Drug-Resistance Assay Using an Integrated Microfluidics

(2019) Long Pang et al.   ANALYTICAL CHEMISTRY

Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety

(2019) Pengjin Ge et al.   CHEMICAL ENGINEERING JOURNAL

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumours

(2018) Qin Dai et al.   ACS Nano

Design of spherically structured 3D in vitro tumor models -Advances and prospects

(2018) L.P. Ferreira et al.   Acta Biomaterialia

In vivo inhibition of circulating tumor cells by two apoptosis-promoting circular aptamers with enhanced specificity

(2018) Haiyan Dong et al.   JOURNAL OF CONTROLLED RELEASE

Strategies to improve tumor penetration of nanomedicines through nanoparticle design

(2018) Ya-Ru Zhang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Deep Tumor-Penetrated Nanocages Improve Accessibility to Cancer Stem Cells for Photothermal-Chemotherapy of Breast Cancer Metastasis

(2018) Tao Tan et al.   Advanced Science

Three-dimensional cell culture models for anticancer drug screening: Worth the effort?

(2017) Eddy-Tim Verjans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PAMAM dendrimers-mediated specific targeting and intracellular apoptosis with aptamer and Bcl-2 converting peptide conjugation

(2017) Jingjing Xie et al.   JOURNAL OF CONTROLLED RELEASE

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy

(2017) Mengjie Hu et al.   MOLECULAR CELL

Design of nanocarriers based on complex biological barriers in vivo for tumor therapy

(2017) Junjie Liu et al.   Nano Today

Smart Superstructures with Ultrahigh pH-Sensitivity for Targeting Acidic Tumor Microenvironment: Instantaneous Size Switching and Improved Tumor Penetration

(2016) Hong-Jun Li et al.   ACS Nano

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy

(2016) Hong-Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aptamer-assembled nanomaterials for fluorescent sensing and imaging

(2016) Danqing Lu et al.   Nanophotonics

Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π–Π Stacking Stabilized Polymeric Micelles

(2015) Yang Shi et al.   ACS Nano

Enhanced Specificity in Capturing and Restraining Circulating Tumor Cells with Dual Antibody-Dendrimer Conjugates

(2015) Jingjing Xie et al.   ADVANCED FUNCTIONAL MATERIALS

Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials

(2015) Jingjing Xie et al.   JOURNAL OF CONTROLLED RELEASE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Aptamer-Functionalized Nanoparticles as “Smart Bombs”: The Unrealized Potential for Personalized Medicine and Targeted Cancer Treatment

(2015) Gregory Benedetto et al.   Targeted Oncology

Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug

(2015) Miles A. Miller et al.   Nature Communications

Nucleic Acid Aptamer-Guided Cancer Therapeutics and Diagnostics: the Next Generation of Cancer Medicine

(2015) Dongxi Xiang et al.   Theranostics

Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid Tumors

(2015) Dongxi Xiang et al.   Theranostics

Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial

(2015) Jingjing Xie et al.   JOURNAL OF NANOBIOTECHNOLOGY

Aptamers Facilitating Amplified Detection of Biomolecules

(2014) Feng Li et al.   ANALYTICAL CHEMISTRY

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Near-Infrared Fluorescence Energy Transfer Imaging of Nanoparticle Accumulation and Dissociation Kinetics in Tumor-Bearing Mice

(2013) Yiming Zhao et al.   ACS Nano

Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture

(2013) Yanling Song et al.   ANALYTICAL CHEMISTRY

Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo

(2012) Keyang Huang et al.   ACS Nano

Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery

(2012) Quan Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors

(2012) S. Huo et al.   CANCER RESEARCH

Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles

(2012) Limin Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipoprotein-Inspired Nanoparticles for Cancer Theranostics

(2011) Kenneth K. Ng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dendrimer-Mediated Multivalent Binding for the Enhanced Capture of Tumor Cells

(2011) Ja Hye Myung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

(2011) Yiyun Cheng et al.   CHEMICAL SOCIETY REVIEWS

Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer

(2011) Ronak Savla et al.   JOURNAL OF CONTROLLED RELEASE

Tailor-Made Dual pH-Sensitive Polymer–Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

(2011) Jin-Zhi Du et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

(2010) Jin-Zhi Du et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles

(2010) Tae-Hee Kim et al.   BIOMATERIALS

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)

(2010) Sifeng Wang et al.   DRUG AND CHEMICAL TOXICOLOGY

In vivo Biodistribution and Urinary Excretion of Mesoporous Silica Nanoparticles: Effects of Particle Size and PEGylation

(2010) Qianjun He et al.   Small

Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: The effects of PEGylation degree and drug conjugation style

(2009) Saijie Zhu et al.   BIOMATERIALS

Spheroid-based drug screen: considerations and practical approach

(2009) Juergen Friedrich et al.   Nature Protocols

A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer

(2008) Siva Kumar Kolluri et al.   CANCER CELL