Combination therapy of niclosamide with gemcitabine inhibited cell proliferation and apoptosis via Wnt/β-catenin/c-Myc signaling pathway by inducing β-catenin ubiquitination in pancreatic cancer

Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

(2021) Lindsey R. Pack et al.   Nature Communications

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

(2021) Jyoti B. Kaushal et al.   Cancers

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma

(2020) Ritu Raj Singh et al.   DRUGS

Pancreatic cancer

(2020) Jonathan D Mizrahi et al.   LANCET

ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers

(2020) Wei Wang et al.   Nature Communications

Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy

(2019) Jiangbo Wang et al.   BIOCHEMICAL JOURNAL

Niclosamide Induces Cell Cycle Arrest in G1 Phase in Head and Neck Squamous Cell Carcinoma Through Let-7d/CDC34 Axis

(2019) Zewen Han et al.   Frontiers in Pharmacology

Chemoresistance in Pancreatic Cancer

(2019) Zeng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Niclosamide: Beyond an antihelminthic drug

(2018) Wei Chen et al.   CELLULAR SIGNALLING

YAP-dependent ubiquitination and degradation of β-catenin mediates inhibition of Wnt signalling induced by Physalin F in colorectal cancer

(2018) Chen Chen et al.   Cell Death & Disease

Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways

(2018) Yang Li et al.   Cell Death & Disease

Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype

(2018) Robert A. Mook et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Niclosamide induces protein ubiquitination and inhibits multiple pro-survival signaling pathways in the human glioblastoma U-87 MG cell line

(2017) Benxu Cheng et al.   PLoS One

Improved survival after palliative resection of unsuspected stage IV pancreatic ductal adenocarcinoma

(2016) Younghwan Kim et al.   HPB

Niclosamide inhibits the proliferation of human osteosarcoma cell lines by inducing apoptosis and cell cycle arrest

(2015) ZONGHUAN LI et al.   ONCOLOGY REPORTS

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug

(2014) Yonghe Li et al.   CANCER LETTERS

Regulation of Wnt/β-catenin signaling by posttranslational modifications

(2014) Chenxi Gao et al.   Cell and Bioscience

Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non-Small Cell Lung Cancer

(2013) R. Li et al.   MOLECULAR CANCER THERAPEUTICS

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of STAT3 by Niclosamide Synergizes with Erlotinib against Head and Neck Cancer

(2013) Rui Li et al.   PLoS One

The  -Catenin Destruction Complex

(2012) J. L. Stamos et al.   Cold Spring Harbor Perspectives in Biology

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death

(2011) So-Jung Park et al.   BMB Reports

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

(2011) T. Osada et al.   CANCER RESEARCH

Niclosamide Suppresses Cancer Cell Growth By Inducing Wnt Co-Receptor LRP6 Degradation and Inhibiting the Wnt/β-Catenin Pathway

(2011) Wenyan Lu et al.   PLoS One

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

(2010) Xiaomei Ren et al.   ACS Medicinal Chemistry Letters

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

(2009) Minyong Chen et al.   BIOCHEMISTRY