The power of effective study design in animal experimentation: Exploring the statistical and ethical implications of asking multiple questions of a data set

SN‐38, an active metabolite of irinotecan, enhances anti‐PD1 treatment efficacy in head and neck squamous cell carcinoma

(2023) Yi‐Mei Lee et al.   JOURNAL OF PATHOLOGY

Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine

(2022) Marina A. Lynch   Frontiers in Aging Neuroscience

Object recognition tasks in rats: Does sex matter?

(2022) Marcela Becegato et al.   Frontiers in Behavioral Neuroscience

Early posttraumatic CSF1R inhibition via PLX3397 leads to time- and sex-dependent effects on inflammation and neuronal maintenance after traumatic brain injury in mice

(2022) Yong Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

Implications for microglial sex differences in tau-related neurodegenerative diseases

(2021) Yasmine V. Doust et al.   NEUROBIOLOGY OF AGING

Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome

(2021) Eleonora Porcu et al.   Nature Communications

Reporting and misreporting of sex differences in the biological sciences

(2021) Yesenia Garcia-Sifuentes et al.   eLife

One size does not fit all – Patterns of vulnerability and resilience in the COVID-19 pandemic and why heterogeneity of disease matters

(2020) Luba Sominsky et al.   BRAIN BEHAVIOR AND IMMUNITY

Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults

(2020) Supinda Bunyavanich et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Remdesivir for COVID-19: challenges of underpowered studies

(2020) John David Norrie   LANCET

Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

(2020) U. Radzikowska et al.   ALLERGY

Enrichment and outcomes in female lab mice

(2019) Christopher Cheleuitte-Nieves   LAB ANIMAL

Predictability of human differential gene expression

(2019) Megan Crow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology

(2019) R.M. Barrientos et al.   BRAIN BEHAVIOR AND IMMUNITY

Chronic predator stress in female mice reduces primordial follicle numbers: implications for the role of ghrelin

(2019) Madeleine R Di Natale et al.   JOURNAL OF ENDOCRINOLOGY

Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models

(2019) Roula Tsonaka et al.   HUMAN MOLECULAR GENETICS

Hormonal and nutritional regulation of postnatal hypothalamic development

(2018) Luba Sominsky et al.   JOURNAL OF ENDOCRINOLOGY

Female mice are protected from space radiation-induced maladaptive responses

(2018) Karen Krukowski et al.   BRAIN BEHAVIOR AND IMMUNITY

The microgenderome revealed: sex differences in bidirectional interactions between the microbiota, hormones, immunity and disease susceptibility

(2018) Ravichandra Vemuri et al.   Seminars in Immunopathology

Training in experimental design and statistics is essential: Response to Jordan

(2018) Stanley E. Lazic et al.   PLOS BIOLOGY

PREPARE: guidelines for planning animal research and testing

(2017) Adrian J Smith et al.   LABORATORY ANIMALS

Sample size calculation while controlling false discovery rate for differential expression analysis with RNA-sequencing experiments

(2016) Ran Bi et al.   BMC BIOINFORMATICS

Reinventing Biostatistics Education for Basic Scientists

(2016) Tracey L. Weissgerber et al.   PLOS BIOLOGY

Reproducibility crisis: Blame it on the antibodies

(2015) Monya Baker   NATURE

The Economics of Reproducibility in Preclinical Research

(2015) Leonard P. Freedman et al.   PLOS BIOLOGY

Are females more variable than males in gene expression? Meta-analysis of microarray datasets

(2015) Yuichiro Itoh et al.   Biology of Sex Differences

PROPER: comprehensive power evaluation for differential expression using RNA-seq

(2014) Hao Wu et al.   BIOINFORMATICS

Impact of Temporal Variation on Design and Analysis of Mouse Knockout Phenotyping Studies

(2014) Natasha A. Karp et al.   PLoS One

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Evaluating Gene Expression in C57BL/6J and DBA/2J Mouse Striatum Using RNA-Seq and Microarrays

(2011) Daniel Bottomly et al.   PLoS One

What’s so special about model organisms?

(2011) Rachel A. Ankeny et al.   STUDIES IN HISTORY AND PHILOSOPHY OF SCIENCE

Systematic variation improves reproducibility of animal experiments

(2010) S Helene Richter et al.   NATURE METHODS

Environmental standardization: cure or cause of poor reproducibility in animal experiments?

(2009) S Helene Richter et al.   NATURE METHODS