Review
Biochemistry & Molecular Biology
Ryota L. Matsuoka, Luke D. Buck, Keerti P. Vajrala, Rachael E. Quick, Olivia A. Card
Summary: Dynamic brain activity requires effective communication between brain tissue and circulating blood, which is facilitated by the heterogeneous brain vasculature. While the molecular basis of this heterogeneity has only recently been elucidated, the combination of historical dye tracer and microscopic observations with modern molecular genetics and omics technologies has greatly expanded our understanding of brain vascular cell heterogeneity. This review provides an overview of the historical advances and current knowledge in this field, and discusses important unresolved questions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Yicheng Long, Xiawei Liu, Zhening Liu
Summary: Based on functional magnetic resonance imaging and multilayer dynamic network model, this manuscript summarizes the potential of brain network's quantified temporal stability in predicting altered brain functions. There are various measures of temporal stability, but no consensus has been reached on the best measure. The temporal stability of brain networks is associated with factors such as sex, age, cognitive functions, head motion, circadian rhythm, and data preprocessing/analyzing strategies, and these factors should be considered in clinical studies. Although multiple psychiatric disorders have been found to be related to altered temporal stability, the measures of temporal stability are still not widely used in clinical diagnoses due to divergent results.
Article
Physics, Multidisciplinary
Adam Haber, Elad Schneidman
Summary: This study measures the functional similarity of simulated networks of neurons by quantifying the similarity of their spiking patterns in response to the same stimuli. It finds that common graph-theory metrics do not accurately predict the similarity of networks' responses. Instead, a functional metric based on synaptic differences accurately predicts the similarity of novel networks. The study also discovers a set of architectural features that can predict the functional similarity of networks with high accuracy.
Article
Behavioral Sciences
Alessandro De Benedictis, Luca de Palma, Maria Camilla Rossi-Espagnet, Carlo Efisio Marras
Summary: Modern epilepsy science emphasizes the involvement of wider patterns of altered neuronal circuits and highlights the value of surgery in addressing epilepsy and neurocognitive issues. While epilepsy is considered a brain network disease, research on connectome-based epilepsy surgery primarily focuses on adults, with limited studies on the pediatric population. This review summarizes the current knowledge on the relevance of white matter surgical anatomy, post-surgical modifications of brain structural connectivity, and their clinical impact within the pediatric context. The possible implications and future perspectives of this approach, particularly in optimizing surgical strategies and predicting the efficacy of epilepsy network analysis, are also discussed.
EPILEPSY & BEHAVIOR
(2023)
Review
Critical Care Medicine
Gregory W. J. Hawryluk, Giuseppe Citerio, Peter Hutchinson, Angelos Kolias, Geert Meyfroidt, Chiara Robba, Nino Stocchetti, Randall Chesnut
Summary: Intracranial pressure (ICP) monitoring is essential in the clinical care of life-threatening brain insults. It helps warn of expanding intracranial mass lesions, prevent or treat herniation events, and facilitate the calculation of cerebral perfusion pressure. However, controversies still exist regarding indications for monitoring, treatment thresholds, and management of intracranial hypertension.
INTENSIVE CARE MEDICINE
(2022)
Article
Neurosciences
Kwangsun Yoo, Monica D. Rosenberg, Young Hye Kwon, Dustin Scheinost, R. Todd Constable, Marvin M. Chun
Summary: This study presents a novel method that models the brain's functional reorganization in response to specific task goals. The method accurately generates task-related connectomes from task-free connectomes and amplifies behaviorally relevant individual differences. Additionally, the study reveals how the brain reorganizes between different cognitive states.
Article
Neurosciences
Sanjay Ghosh, Ashish Raj, Srikantan S. Nagarajan
Summary: This article introduces a computational framework that reconstructs functional connectivity from structural connectivity by identifying a joint subspace of eigenmodes. It is found that a small number of these eigenmodes are sufficient for reconstruction and the proposed algorithm shows competitive performance and better interpretability compared to existing methods.
Article
Multidisciplinary Sciences
Martijn P. van den Heuvel, Dirk Jan Ardesch, Lianne H. Scholtens, Siemon C. de Lange, Neeltje E. M. van Haren, Iris E. C. Sommer, Udo Dannlowski, Jonathan Repple, Todd M. Preuss, William D. Hopkins, James K. Rilling
Summary: This study examines the neural connectivity underlying cognitive abilities in chimpanzees and humans. It finds that chimpanzees with higher cognitive skills have stronger connectivity among brain networks associated with comparable abilities in humans. The study also identifies differences in brain networks related to specialized functions between the two species. These findings suggest that core neural systems for cognition may have evolved before the divergence of chimpanzees and humans, along with distinct investments in other brain networks.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Integrative & Complementary Medicine
Md. Shimul Bhuia, Md. Mizanur Rahaman, Tawhida Islam, Mehedi Hasan Bappi, Md. Iqbal Sikder, Kazi Nadim Hossain, Fatama Akter, Abdullah Al Shamsh Prottay, Md. Rokonuzzman, Eda Sonmez Gurer, Daniela Calina, Muhammad Torequl Islam, Javad Sharifi-Rad
Summary: This study investigated the neurobiological effects and mechanisms of gallic acid (GA) by analyzing published data from reputable databases. The findings suggest that GA could be a potential treatment for various neurological diseases and disorders. However, more research is needed to establish GA as a neuroprotective drug.
Article
Neurosciences
A. David Edwards, Daniel Rueckert, Stephen M. Smith, Samy Abo Seada, Amir Alansary, Jennifer Almalbis, Joanna Allsop, Jesper Andersson, Tomoki Arichi, Sophie Arulkumaran, Matteo Bastiani, Dafnis Batalle, Luke Baxter, Jelena Bozek, Eleanor Braithwaite, Jacqueline Brandon, Olivia Carney, Andrew Chew, Daan Christiaens, Raymond Chung, Kathleen Colford, Lucilio Cordero-Grande, Serena J. Counsell, Harriet Cullen, John Cupitt, Charles Curtis, Alice Davidson, Maria Deprez, Louise Dillon, Konstantina Dimitrakopoulou, Ralica Dimitrova, Eugene Duff, Shona Falconer, Seyedeh-Rezvan Farahibozorg, Sean P. Fitzgibbon, Jianliang Gao, Andreia Gaspar, Nicholas Harper, Sam J. Harrison, Emer J. Hughes, Jana Hutter, Mark Jenkinson, Saad Jbabdi, Emily Jones, Vyacheslav Karolis, Vanessa Kyriakopoulou, Gregor Lenz, Antonios Makropoulos, Shaihan Malik, Luke Mason, Filippo Mortari, Chiara Nosarti, Rita G. Nunes, Camilla O'Keeffe, Jonathan O'Muircheartaigh, Hamel Patel, Jonathan Passerat-Palmbach, Maximillian Pietsch, Anthony N. Price, Emma C. Robinson, Mary A. Rutherford, Andreas Schuh, Stamatios Sotiropoulos, Johannes Steinweg, Rui Pedro Azeredo Gomes Teixeira, Tencho Tenev, Jacques-Donald Tournier, Nora Tusor, Alena Uus, Katy Vecchiato, Logan Z. J. Williams, Robert Wright, Julia Wurie, Joseph V. Hajnal
Summary: The Developing Human Connectome Project is an open science resource that provides researchers with data on typical and atypical brain development during the perinatal period. With a collection of MRI brain datasets and collateral data from fetal and neonatal participants, this project offers valuable insights into brain development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Environmental Sciences
John P. Jr Jr Wise, Jamie L. Young, Jun Cai, Lu Cai
Summary: Hexavalent chromium is a global environmental pollutant that is increasingly being recognized as a neurotoxicant. Studies have shown that mitotic cells in the brain play crucial roles in overall brain and body health, and hexavalent chromium may have subtle deleterious effects on the brain.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Bo-Yong Park, Casey Paquola, Richard A. Bethlehem, Oualid Benkarim, Bratislav Misic, Jonathan Smallwood, Edward T. Bullmore, Boris C. Bernhardt
Summary: This study analyzed the development of structural and functional brain networks in adolescents and found that multiple corticocortical structural networks continue to differentiate in youth. Regions with more similar structural wiring were more likely to be functionally coupled. Additionally, increased structural differentiation was associated with reduced functional interactions, illustrating the interaction between brain structure and function in adolescent development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
James C. Pang, Leonardo L. Gollo, James A. Roberts
Summary: This study systematically addresses the emergence of synchronization in the human brain network in the presence of stochastic perturbations. Results show that the model can produce complex synchronization patterns, with structural hub nodes benefiting the most from the addition of noise. This stochastic synchronization effect is driven by the intrinsic hierarchy of neural timescales and the complex topology of the connectome.
Review
Neurosciences
Hongzan Sun, Yong He, Heqi Cao
Summary: NSFC has been funding various research programs related to fMRI over the past two decades, with increasing support particularly in the General Program and Key Program. Leading research institutes in economically developed provinces and municipalities received the most support and established close collaboration relationships. Notable achievements in data analysis methods, brain connectomes, and computational platforms as well as their applications in brain disorders were reviewed.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemical Research Methods
Xingzhong Zhao, Jingqi Chen, Peipei Xiao, Jianfeng Feng, Qing Nie, Xing-Ming Zhao
Summary: Using the TCA method, age-specific cortex (ASC) gene signatures were identified, showing significant correlations with cortical thickness and myelination. These gene signatures also help elucidate the molecular mechanisms of neuropsychiatric disorders.
BRIEFINGS IN BIOINFORMATICS
(2021)
