Probing a distinct druggable tubulin binding site with gatorbulins 1–7, their metabolic and physicochemical properties, and pharmacological consequences

Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs

(2022) Sheo B. Singh   JOURNAL OF NATURAL PRODUCTS

Microtentacle Formation in Ovarian Carcinoma

(2022) Jocelyn C. Reader et al.   Cancers

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

(2021) Susan Matthew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

(2021) Jianhong Yang et al.   Science Advances

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

(2020) Lin Du et al.   Nature Communications

Microtubule-Targeting Drugs: More than Antimitotics

(2019) Roma Kaul et al.   JOURNAL OF NATURAL PRODUCTS

Microtubule dynamics: an interplay of biochemistry and mechanics

(2018) Gary J. Brouhard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evaluation of class I HDAC isoform selectivity of largazole analogues

(2014) Bumki Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanism of Action of Colchicine in the Treatment of Gout

(2014) Nicola Dalbeth et al.   CLINICAL THERAPEUTICS

Improved Total Synthesis and Biological Evaluation of Potent Apratoxin S4 Based Anticancer Agents with Differential Stability and Further Enhanced Activity

(2014) Qi-Yin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improved Docking of Polypeptides with Glide

(2013) Ivan Tubert-Brohman et al.   Journal of Chemical Information and Modeling

Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4- and E2F-mediated gene transcription

(2010) Karl J. Hale et al.   CHEMICAL COMMUNICATIONS

Total Synthesis of (+)-Azinothricin and (+)-Kettapeptin

(2009) Karl J. Hale et al.   ORGANIC LETTERS

TTI-237: A Novel Microtubule-Active Compound with In vivo Antitumor Activity

(2008) C. F. Beyer et al.   CANCER RESEARCH