Microtentacle Formation in Ovarian Carcinoma

Randomized phase II trial of weekly ixabepilone with or without biweekly bevacizumab for platinum-resistant or refractory ovarian/fallopian tube/primary peritoneal cancer

(2021) Dana Roque et al.   GYNECOLOGIC ONCOLOGY

Photodynamic Therapy and the Biophysics of the Tumor Microenvironment

(2020) Aaron J. Sorrin et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cofilin-induced structural changes in actin filaments stay local

(2020) Shoichiro Ono   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell EMT-related transcriptional analysis revealed intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites

(2020) Tongtong Kan et al.   ONCOGENE

A mode of cell adhesion and migration facilitated by CD44-dependent microtentacles

(2020) Kayla J. Wolf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress

(2020) Shubhankar Nath et al.   Journal of Clinical Medicine

Clear cell carcinoma of the ovary: a clinical and molecular perspective

(2020) Yasushi Iida et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics

(2019) Sara K. Coulup et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers

(2018) Gopal P. Pathak et al.   MOLECULAR THERAPY

Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer

(2018) Willemien J. van Driel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Capping protein regulates actin dynamics during cytokinetic midbody maturation

(2018) Stephen J. Terry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates

(2018) Yuliya Klymenko et al.   Disease Models & Mechanisms

Ascites Volumes and the Ovarian Cancer Microenvironment

(2018) Marie-France Penet et al.   Frontiers in Oncology

Cytoskeletal organization in microtentacles

(2017) Alison N. Killilea et al.   EXPERIMENTAL CELL RESEARCH

An evaluation of progression free survival and overall survival of ovarian cancer patients with clear cell carcinoma versus serous carcinoma treated with platinum therapy: An NRG Oncology/Gynecologic Oncology Group experience

(2017) Kate E. Oliver et al.   GYNECOLOGIC ONCOLOGY

Taxol®: The First Microtubule Stabilizing Agent

(2017) Chia-Ping Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Actin cortex architecture regulates cell surface tension

(2017) Priyamvada Chugh et al.   NATURE CELL BIOLOGY

Involvement of β- and γ-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells

(2017) Aleksandra Simiczyjew et al.   PLoS One

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Septin remodeling is essential for the formation of cell membrane protrusions (microtentacles) in detached tumor cells

(2017) Kristine Østevold et al.   Oncotarget

Extracting microtentacle dynamics of tumor cells in a non-adherent environment

(2017) Eleanor C. Ory et al.   Oncotarget

Anticancer effects of clinically acceptable colchicine concentrations on human gastric cancer cell lines

(2016) Zu-Yau Lin et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response

(2016) Kristi R. Chakrabarti et al.   Oncotarget

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Weekly ixabepilone with or without biweekly bevacizumab in the treatment of recurrent or persistent uterine and ovarian/primary peritoneal/fallopian tube cancers: A retrospective review

(2015) Dana M. Roque et al.   GYNECOLOGIC ONCOLOGY

 -Tubulin Acetylation Elevated in Metastatic and Basal-like Breast Cancer Cells Promotes Microtentacle Formation, Adhesion, and Invasive Migration

(2014) A. E. Boggs et al.   CANCER RESEARCH

Class III β-tubulin overexpression in ovarian clear cell and serous carcinoma as a maker for poor overall survival after platinum/taxane chemotherapy and sensitivity to patupilone

(2013) Dana M. Roque et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Class III β-tubulin overexpression within the tumor microenvironment is a prognostic biomarker for poor overall survival in ovarian cancer patients treated with neoadjuvant carboplatin/paclitaxel

(2013) Dana M. Roque et al.   CLINICAL & EXPERIMENTAL METASTASIS

Microtubule Dynamics Control Tail Retraction in Migrating Vascular Endothelial Cells

(2013) A. Ganguly et al.   MOLECULAR CANCER THERAPEUTICS

Evaluating cell lines as tumour models by comparison of genomic profiles

(2013) Silvia Domcke et al.   Nature Communications

Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration

(2012) Angela Ogden et al.   CANCER AND METASTASIS REVIEWS

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

(2012) Kensaku Mizuno   CELLULAR SIGNALLING

Actin cortex mechanics and cellular morphogenesis

(2012) Guillaume Salbreux et al.   TRENDS IN CELL BIOLOGY

Mitosis is not a key target of microtubule agents in patient tumors

(2011) Edina Komlodi-Pasztor et al.   Nature Reviews Clinical Oncology

Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells

(2010) Jennifer R. Yoon et al.   BREAST CANCER RESEARCH AND TREATMENT

Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells

(2010) M. A. Matrone et al.   CANCER RESEARCH

Epithelial-to-Mesenchymal Transition Promotes Tubulin Detyrosination and Microtentacles that Enhance Endothelial Engagement

(2010) R. A. Whipple et al.   CANCER RESEARCH

Differences in Tumor Type in Low-stage Versus High-stage Ovarian Carcinomas

(2010) Martin Köbel et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells

(2010) M A Matrone et al.   ONCOGENE

Antimitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cells

(2009) Eric M. Balzer et al.   BREAST CANCER RESEARCH AND TREATMENT

Preclinical efficacy spectrum and pharmacokinetics of ixabepilone

(2008) Francis Y. F. Lee et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY