Oxfendazole Induces Apoptosis in Ovarian Cancer Cells by Activating JNK/MAPK Pathway and Inducing Reactive Oxygen Species Generation

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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Treatment of breast and colon cancer cell lines with anti-helmintic benzimidazoles mebendazole or albendazole results in selective apoptotic cell death

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Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway

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Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways

(2021) Hefei Li et al.   Frontiers in Cell and Developmental Biology

Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity

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ERK/MAPK signalling pathway and tumorigenesis (Review)

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RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway

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The anthelmintic agent oxfendazole inhibits cell growth in non‑small cell lung cancer by suppressing c‑Src activation

(2019) Dafu Xu et al.   Molecular Medicine Reports

USP11 promotes growth and metastasis of colorectal cancer via PPP1CA-mediated activation of ERK/MAPK signaling pathway

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Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma

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Comprehensive review on how platinum- and taxane-based chemotherapy of ovarian cancer affects biology of normal cells

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Ovarian cancer stem cells and their role in drug resistance

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Physiological role of reactive oxygen species as promoters of natural defenses

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Reactive oxygen species and cancer paradox: To promote or to suppress?

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Cellular mechanisms and physiological consequences of redox-dependent signalling

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Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity

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Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

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(2013) Robert L. Coleman et al.   Nature Reviews Clinical Oncology

Fomitoside-K from Fomitopsis nigra Induces Apoptosis of Human Oral Squamous Cell Carcinomas (YD-10B) via Mitochondrial Signaling Pathway

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Impairment of the Ubiquitin-Proteasome Pathway by MethylN-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells

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Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats

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Molecular Characterization of a New Ovarian Cancer Cell Line, YDOV-151, Established from Mucinous Cystadenocarcinoma

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