Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold

Synthesis and applications of mirror-image proteins

(2023) Katriona Harrison et al.   Nature Reviews Chemistry

Pharmacokinetics, biodistribution and toxicology of novel cell-penetrating peptides

(2023) L. Reveret et al.   Scientific Reports

Easily Established and Multifunctional Synthetic Nanobody Libraries as Research Tools

(2022) Bingying Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Total Chemical Synthesis of a Functionalized GFP Nanobody

(2022) Yara Huppelschoten et al.   CHEMBIOCHEM

D‐Peptide and D‐Protein technology: Recent advances, challenges, and opportunities

(2022) Alexander Lander et al.   CHEMBIOCHEM

Monoclonal antibodies: Trends in therapeutic success and commercial focus

(2022) Michael S. Kinch et al.   DRUG DISCOVERY TODAY

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

(2022) Seisho Kinoshita et al.   PROTEIN SCIENCE

A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth

(2021) Paul S. Marinec et al.   ACS Chemical Biology

Immunogenicity and humanization of single‐domain antibodies

(2021) Martin A. Rossotti et al.   FEBS Journal

The immunogenicity of an anti-EGFR single domain antibody (VHH) is enhanced by misfolded amorphous aggregation but not by heat-induced aggregation

(2020) Md. Golam Kibria et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Analysis of the bone fracture targeting properties of osteotropic ligands

(2020) Jeffery J. Nielsen et al.   JOURNAL OF CONTROLLED RELEASE

Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors

(2019) Keitou Shu et al.   BIOCONJUGATE CHEMISTRY

Removal of a Conserved Disulfide Bond Does Not Compromise Mechanical Stability of a VHH Antibody Complex

(2019) Haipei Liu et al.   NANO LETTERS

VHH characterization. Comparison of recombinant with chemically synthesized anti‐HER2 VHH

(2019) Lucie Hartmann et al.   PROTEIN SCIENCE

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative analysis of nanobody sequence and structure data

(2018) Laura S. Mitchell et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Yeast surface display platform for rapid discovery of conformationally selective nanobodies

(2018) Conor McMahon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Caplacizumab: First Global Approval

(2018) Sean Duggan   DRUGS

Immunogenicity of Protein Pharmaceuticals

(2018) Robert Dingman et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Native Chemical Ligation at Serine Revisited

(2018) Benoît Snella et al.   ORGANIC LETTERS

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics

(2017) Peter Bannas et al.   Frontiers in Immunology

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

(2016) Maruti Uppalapati et al.   ACS Chemical Biology

Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis

(2016) Suman Kumar Maity et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Resurfaced cell-penetrating nanobodies: A potentially general scaffold for intracellularly targeted protein discovery

(2016) Virginia J. Bruce et al.   PROTEIN SCIENCE

Dynamic Biostability, Biodistribution, and Toxicity of l/d-Peptide-Based Supramolecular Nanofibers

(2015) Cuihong Yang et al.   ACS Applied Materials & Interfaces

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics

(2015) Dhaval K. Shah   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Chemical Protein Synthesis Using a Second-Generation N-Acylurea Linker for the Preparation of Peptide-Thioester Precursors

(2015) Juan B. Blanco-Canosa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peptideo-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis

(2014) Jia-Xing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Labeling of Cysteine-Tagged Camelid Single-Domain Antibody-Fragments for Use in Molecular Imaging

(2014) Sam Massa et al.   BIOCONJUGATE CHEMISTRY

High-Efficiency Solid Phase Peptide Synthesis (HE-SPPS)

(2014) Jonathan M. Collins et al.   ORGANIC LETTERS

Removing T-cell epitopes with computational protein design

(2014) C. King et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro nanobody discovery for integral membrane protein targets

(2014) Rupak Doshi et al.   Scientific Reports

Nanobody: The “Magic Bullet” for Molecular Imaging?

(2014) Rubel Chakravarty et al.   Theranostics

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

(2011) H. Ulrichts et al.   BLOOD

A Self-Assembled Complex with a Titanium(IV) Catecholate Core as a Potential Bimodal Contrast Agent

(2011) Geert Dehaen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aspartimide formation in peptide chemistry: occurrence, prevention strategies and the role of N-hydroxylamines

(2011) Ramon Subirós-Funosas et al.   TETRAHEDRON

The immunogenicity of humanized and fully human antibodies

(2010) Fiona A. Harding et al.   mAbs

Structural and thermodynamic analysis of the GFP:GFP-nanobody complex

(2010) Marta H. Kubala et al.   PROTEIN SCIENCE

An Efficient Fmoc-SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation

(2008) Juan B. Blanco-Canosa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein therapeutics: a summary and pharmacological classification

(2007) Benjamin Leader et al.   NATURE REVIEWS DRUG DISCOVERY