Diligent Design Enables Antibody-ASO Conjugates with Optimal Pharmacokinetic Properties

Assessing developability early in the discovery process for novel biologics

(2023) Monica L. Fernández-Quintero et al.   mAbs

A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future

(2023) Emily Holz et al.   Pharmaceutics

Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features

(2022) Peter H. Hagedorn et al.   Nucleic Acid Therapeutics

Identification and Characterization of a MAPT-targeting Locked Nucleic Acid Antisense Oligonucleotide Therapeutic for Tauopathies

(2022) Amy Easton et al.   Molecular Therapy-Nucleic Acids

Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable Patients

(2022) Romy Mosch et al.   Frontiers in Immunology

Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics

(2022) Michel Siegel et al.   Pharmaceutics

The administration of antisense oligonucleotide golodirsen reduces pathological regeneration in patients with Duchenne muscular dystrophy

(2021) Dominic Scaglioni et al.   Acta Neuropathologica Communications

Antibody-Oligonucleotide Conjugates: A Twist to Antibody-Drug Conjugates

(2021) Julien Dugal-Tessier et al.   Journal of Clinical Medicine

Casimersen: First Approval

(2021) Matt Shirley   DRUGS

Safety, tolerability, and pharmacokinetics of casimersen in patients with D uchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double‐blind, placebo‐controlled, dose‐titration trial

(2021) Kathryn R. Wagner et al.   MUSCLE & NERVE

Copper‐Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering

(2021) Hong Yeol Yoon et al.   ADVANCED MATERIALS

An Insight into FDA Approved Antibody-Drug Conjugates for Cancer Therapy

(2021) Juliana T. W. Tong et al.   MOLECULES

Systemic Brain Delivery of Antisense Oligonucleotides across the Blood-Brain Barrier with a Glucose-Coated Polymeric Nanocarrier

(2020) Hyun Su Min et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Viltolarsen: First Approval

(2020) Sohita Dhillon   DRUGS

Enabling Routine MHC-II Associated Peptide ProteomicS (MAPPs) for Risk Assessment of Drug-Induced Immunogenicity

(2020) Guido Steiner et al.   JOURNAL OF PROTEOME RESEARCH

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Immunogenicity of biologic agents in rheumatology

(2020) Vibeke Strand et al.   Nature Reviews Rheumatology

Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment

(2019) Daniel M. Ramos et al.   JOURNAL OF CLINICAL INVESTIGATION

Current possibilities of liquid chromatography for the characterization of antibody-drug conjugates

(2018) Balázs Bobály et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Impact of Payload Hydrophobicity on the Stability of Antibody–Drug Conjugates

(2018) Jakob W. Buecheler et al.   MOLECULAR PHARMACEUTICS

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

(2018) Merrill D. Benson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy

(2018) Eugenio Mercuri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of a microbial transglutaminase enabling highly site-specific labeling of proteins

(2017) Wojtek Steffen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life

(2017) Pernille Foged Jensen et al.   MOLECULAR & CELLULAR PROTEOMICS

FDA-Approved Oligonucleotide Therapies in 2017

(2017) Cy A. Stein et al.   MOLECULAR THERAPY

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants

(2017) Florian Cymer et al.   Bioanalysis

Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain

(2016) Kapil Gadkar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Aggregation of Antibody Drug Conjugates at Room Temperature: SAXS and Light Scattering Evidence for Colloidal Instability of a Specific Subpopulation

(2016) B. Frka-Petesic et al.   LANGMUIR

Immunogenicity assessment of monoclonal antibody products: A simulated case study correlating antibody induction with clinical outcomes

(2015) Ivana Knezevic et al.   BIOLOGICALS

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

(2015) C. Peters et al.   BIOSCIENCE REPORTS

Mipomersen preferentially reduces small low-density lipoprotein particle number in patients with hypercholesterolemia

(2015) Raul D. Santos et al.   Journal of Clinical Lipidology

FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin

(2015) Michal Pyzik et al.   JOURNAL OF IMMUNOLOGY

Antibody Conjugates with Unnatural Amino Acids

(2015) Trevor J. Hallam et al.   MOLECULAR PHARMACEUTICS

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Transglutaminase-Based Chemo-Enzymatic Conjugation Approach Yields Homogeneous Antibody–Drug Conjugates

(2014) Patrick Dennler et al.   BIOCONJUGATE CHEMISTRY

Versatility of Microbial Transglutaminase

(2014) Pavel Strop   BIOCONJUGATE CHEMISTRY

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

(2014) Vaheh Oganesyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates

(2014) Trinna L. Cuellar et al.   NUCLEIC ACIDS RESEARCH

Intrathecal delivery of protein therapeutics to the brain: A critical reassessment

(2014) Pericles Calias et al.   PHARMACOLOGY & THERAPEUTICS

Eteplirsen for the treatment of Duchenne muscular dystrophy

(2013) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Investigation into Temperature-Induced Aggregation of an Antibody Drug Conjugate

(2013) Nia S. Beckley et al.   BIOCONJUGATE CHEMISTRY

Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

(2013) Tilman Schlothauer et al.   mAbs

Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation

(2011) Mariusz P. Madej et al.   BIOTECHNOLOGY AND BIOENGINEERING

Site-Specific and Stoichiometric Modification of Antibodies by Bacterial Transglutaminase

(2010) Simone Jeger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

Nonnatural Amino Acids for Site-Specific Protein Conjugation

(2009) Albert J. de Graaf et al.   BIOCONJUGATE CHEMISTRY

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Novel applications for microbial transglutaminase beyond food processing

(2008) Yang Zhu et al.   TRENDS IN BIOTECHNOLOGY