Drug Repurposing Patent Applications April–June 2023

Autism Spectrum Disorder

(2023) Tomoya Hirota et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NS5A domain I antagonises PKR to facilitate the assembly of infectious hepatitis C virus particles

(2023) Shucheng Chen et al.   PLoS Pathogens

Diagnostic and therapeutic value of P2Y12R in epilepsy

(2023) Xiang Chen et al.   Frontiers in Pharmacology

Risdiplam: an investigational survival motor neuron 2 (SMN2) splicing modifier for spinal muscular atrophy (SMA)

(2022) Theodora Markati et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Lamivudine, a reverse transcriptase inhibitor, rescues cognitive deficits in a mouse model of down syndrome

(2022) Maria Martinez de Lagran et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pruritus as a Distinctive Feature of Type 2 Inflammation

(2021) Simone Garcovich et al.   Vaccines

Lamivudine improves cognitive decline in SAMP8 mice: Integrating in vivo pharmacological evaluation and network pharmacology

(2021) Ming Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Novel molecular targeted therapies for patients with neurofibromatosis type 1 with inoperable plexiform neurofibromas: a comprehensive review

(2021) I. Solares et al.   ESMO Open

Mechanism for the activation of the anaplastic lymphoma kinase receptor

(2021) Andrey V. Reshetnyak et al.   NATURE

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

(2021) Thomas Molina et al.   Open Biology

Deiodinases and the Three Types of Thyroid Hormone Deiodination Reactions

(2021) Laura Sabatino et al.   Endocrinology and Metabolism

Tibolone as Hormonal Therapy and Neuroprotective Agent

(2020) Juan Pablo Del Río et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways

(2020) Sunyuan Zhang et al.   Nature Communications

Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease

(2019) Oliver H. Tam et al.   Mobile DNA

Dipyridamole impairs autophagic flux and exerts antiproliferative activity on prostate cancer cells

(2019) Marcos P. Thomé et al.   EXPERIMENTAL CELL RESEARCH

Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties

(2019) Malik Bouasse et al.   Scientific Reports

Nitroxoline: repurposing its antimicrobial to antitumor application

(2019) Janko Kos et al.   ACTA BIOCHIMICA POLONICA

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

(2018) Andrea Cipriani et al.   LANCET

Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients

(2018) Xinmiao Hu et al.   MEDICINE

Skeletal muscle fibrosis: an overview

(2018) Mohamed A. A. Mahdy   CELL AND TISSUE RESEARCH

New tricks for an old dog: A repurposing approach of apomorphine

(2018) Manon Auffret et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions

(2018) Boadie W. Dunlop et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Fear extinction and memory reconsolidation as critical components in behavioral treatment for posttraumatic stress disorder and potential augmentation of these processes

(2017) Noelle B. Smith et al.   NEUROSCIENCE LETTERS

Restoring synaptic plasticity and memory in mouse models of Alzheimer’s disease by PKR inhibition

(2017) Kyoung-Doo Hwang et al.   Molecular Brain

Nalcn Is a "Leak" Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing

(2016) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Cerebellar ataxias: β-III spectrin's interactions suggest common pathogenic pathways

(2016) Emma Perkins et al.   JOURNAL OF PHYSIOLOGY-LONDON

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

(2016) Geoffrey Burnstock   NEUROPHARMACOLOGY

Apomorphine - pharmacological properties and clinical trials in Parkinson's disease

(2016) Peter Jenner et al.   PARKINSONISM & RELATED DISORDERS

Posttraumatic Stress Disorder in Critical Illness Survivors

(2015) Ann M. Parker et al.   CRITICAL CARE MEDICINE

Disease Mechanisms and Therapeutic Approaches in Spinal Muscular Atrophy

(2015) S. Tisdale et al.   JOURNAL OF NEUROSCIENCE

Preclinical evaluation of bortezomib/dipyridamole novel combination as a potential therapeutic modality for hematologic malignancies

(2014) Ahmed E. Goda et al.   Molecular Oncology

A systematic review of reboxetine for treating patients with attention deficit hyperactivity disorder

(2014) Ahmad Ghanizadeh   NORDIC JOURNAL OF PSYCHIATRY

Classical and pleiotropic actions of dipyridamole: Not enough light to illuminate the dark tunnel?

(2014) Pitchai Balakumar et al.   PHARMACOLOGICAL RESEARCH

Spinal Muscular Atrophy and the Antiapoptotic Role of Survival of Motor Neuron (SMN) Protein

(2013) Ryan S. Anderton et al.   MOLECULAR NEUROBIOLOGY

Drug safety data mining with a tree-based scan statistic

(2013) Martin Kulldorff et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition

(2011) Lixin Dai et al.   BMC BIOCHEMISTRY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS