☆ 4.6 Editorial Material

Not just loading and age: the dynamics of osteoarthritis, obesity and inflammation

MEDICAL JOURNAL OF AUSTRALIA (2016)

Journal

MEDICAL JOURNAL OF AUSTRALIA

Volume 204, Issue 2, Pages 47-U21

Publisher

AUSTRALASIAN MED PUBL CO LTD

DOI: 10.5694/mja15.01069

Keywords

-

Categories

Medicine, General & Internal

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Engineering, Electrical & Electronic

Not Just Age but Age and Quality of Information

Nived Rajaraman, Rahul Vaze, Goonwanth Reddy

Summary: A versatile scheduling problem, called the age and quality of information (AQI), is considered to model a tradeoff between age of information, quality/distortion, and energy transmission cost. A greedy algorithm and a maximum weight matching based algorithm are shown to be 2-competitive for the AQI problem.

IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS (2021)

Add to Collection

Article Geriatrics & Gerontology

Are fat and sugar just as detrimental in old age?

Ana P. Valencia, Nitin Nagaraj, Deena H. Osman, Peter S. Rabinovitch, David J. Marcinek

Summary: Experimental studies have shown that high-fat diets may exacerbate age-related disease and hallmarks of aging in young animals, while non-obesogenic high-fat diets may be beneficial in old age. Conversely, high-sugar diets can induce mitochondrial dysfunction or inflammation in young rodents without requiring an obesogenic effect.

GEROSCIENCE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Roxadustat: Not just for anemia

Xiaoyu Zhu, Lili Jiang, Xuejiao Wei, Mengtuan Long, Yujun Du

Summary: Roxadustat is a newly approved hypoxia-inducible factor prolyl hydroxylase inhibitor that has shown favorable safety and efficacy in treating renal anemia. Studies have also indicated its potential for treating other hypoxia-related diseases. Although no significant adverse or off-target effects have been found in clinical studies of roxadustat, clinicians should remain vigilant about these possibilities.

FRONTIERS IN PHARMACOLOGY (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development

Kelly Warmink, Prateeksha Vinod, Nicoline M. Korthagen, Harrie Weinans, Jaqueline L. Rios

Summary: Obesity is associated with osteoarthritis, as it alters adipokine release, increases pro-inflammatory macrophage activity, and affects joint immune regulation. Studying inflammatory macrophage expression and inhibiting inflammatory macrophage phenotype polarization may provide insights into disease pathogenesis and therapy. Imaging techniques and blood-based biomarker analysis can enable early detection of osteoarthritis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Editorial Material Biology

OSTEOPOROTIC FRACTURE Bone age is not just for kids

Jane A. Cauley, Dolores M. Shoback

Summary: More informed discussions between physicians and older adults about the consequences of an initial osteoporotic fracture could lead to more patients considering treatments to prevent future fractures.

ELIFE (2021)

Add to Collection

Article Endocrinology & Metabolism

Hyperglycemia and Not Hyperinsulinemia Mediates Diabetes-Induced Memory CD8 T-Cell Dysfunction

Inga Kavazovic, Mia Krapic, Ammarina Beumer-Chuwonpad, Bojan Polic, Tamara Turk Wensveen, Niels A. Lemmermann, Klaas P. J. M. van Gisbergen, Felix M. Wensveen

Summary: Type 2 diabetes leads to impaired antiviral and anticancer capacity of memory CD8 T cells due to hyperglycemia, rather than hyperinsulinemia, in the context of obesity.

DIABETES (2022)

Add to Collection

Article Medicine, General & Internal

Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets

Dominika E. Nanus, Amel Badoume, Susanne N. Wijesinghe, Andrea M. Halsey, Patrick Hurley, Zubair Ahmed, Rajesh Botchu, Edward T. Davis, Mark A. Lindsay, Simon W. Jones

Summary: Research on patients with knee osteoarthritis has shown that synovial inflammation is associated with pain severity, and synovial tissue from areas associated with pain exhibits different features and subsets of synovial fibroblasts. Additionally, the secretions of synovial fibroblasts have an impact on neuronal growth.

EBIOMEDICINE (2021)

Add to Collection

Article Nutrition & Dietetics

β-Carotene Status Is Associated with Inflammation and Two Components of Metabolic Syndrome in Patients with and without Osteoarthritis

Chi-Hua Yen, Po-Sheng Chang, Ching-Ju Chiu, Yu-Yun Huang, Ping-Ting Lin

Summary: In this study, obese osteoarthritis patients showed higher rates of metabolic syndrome, abdominal obesity, and lower beta-carotene status compared to non-obese patients and controls. A higher beta-carotene status was found to be inversely associated with the risk of metabolic syndrome and inflammation, particularly in cases with low-grade inflammation. This suggests that beta-carotene status could potentially predict the risk of metabolic syndrome and inflammation in patients with or without osteoarthritis.

NUTRIENTS (2021)

Add to Collection

Article Biophysics

Cyclic loading regime considered beneficial does not protect injured and interleukin-1-inflamed cartilage from post-traumatic osteoarthritis

Atte S. A. Eskelinen, Cristina Florea, Petri Tanska, Han-Hwa K. Hung, Eliot H. Frank, Santtu Mikkonen, Petteri Nieminen, Petro Julkunen, Alan J. Grodzinsky, Rami K. Korhonen

Summary: This study investigated the early progression of post-traumatic osteoarthritis using an in vitro model, finding that cyclic loading may be beneficial to deep cartilage but becomes ineffective in preventing further degradation triggered by injury and cytokines.

JOURNAL OF BIOMECHANICS (2022)

Add to Collection

Review Cell Biology

A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Gregory Livshits, Alexander Kalinkovich

Summary: The increase in lifespan and proportion of older adults has resulted in a rise in age-associated chronic diseases, such as sarcopenia and obesity. Sestrins, a family of proteins, play a crucial role in cellular adaption to stress and have shown potential in treating sarcopenia and obesity in pre-clinical models. Activation of sestrins can eliminate senescent cells and resolve inflammation. Therefore, sestrin activation, inflammation resolution, and senescent cell elimination may be a novel treatment strategy for age-associated sarcopenia and obesity.

AGEING RESEARCH REVIEWS (2023)

Add to Collection

Review Orthopedics

Cartilage tissue engineering for obesity-induced osteoarthritis: Physiology, challenges, and future prospects

Antonia RuJia Sun, Anjaneyulu Udduttula, Jian Li, Yanzhi Liu, Pei-Gen Ren, Peng Zhang

Summary: Obesity is recognized as the most influential risk factor for the initiation and progression of osteoarthritis, leading to chronic low-grade inflammation and abnormal mechanical loading. Tissue-engineering-based strategies for cartilage regeneration offer promising treatment breakthroughs, but face challenges in obese patients due to altered biomechanics and persistent inflammation. Innovative therapeutic approaches are needed to effectively repair and restore damaged synovial joints in this population.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2021)

Add to Collection

Article Physiology

Effects of different obesogenic diets on joint integrity, inflammation and intermediate monocyte levels in a rat groove model of osteoarthritis

K. Warmink, J. L. Rios, D. R. van Valkengoed, P. Vinod, N. M. Korthagen, H. Weinans

Summary: Obesogenic diets exacerbate osteoarthritis by inducing joint damage and inflammation. High-fat and high-fat/high-sucrose diets result in increased metabolic dysregulation, synovial inflammation, and CD68 staining in bone marrow.

FRONTIERS IN PHYSIOLOGY (2023)

Add to Collection

Article Immunology

Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis

Alice Courties, Juliette Petit, Ariane Do, Manon Legris, Ines Kouki, Audrey Pigenet, Pradeep K. Sacitharan, Francois-Paul Ehkirch, Francis Berenbaum, Jeremie Sellam

Summary: This study investigated the role of non-neuronal cholinergic system in osteoarthritis (OA). The results showed that the cholinergic system, through alpha 7nAchR, can counteract the effects of inflammation on osteoblasts. Deletion of alpha 7nAchR may limit cartilage degradation in age-related OA. Therefore, enhancing the cholinergic system could be a potential therapeutic target, although it may depend on CHRFAM7A expression.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Rehabilitation

Association of Osteoarthritis Prevalence With Age and Obesity Factors in Organization for Economic Cooperation and Development Countries

Gamze Kus, Zeynal Yasaci, Canser Boz, Ezgi Turkmen

Summary: Based on macro data from 36 Organization for Economic Cooperation and Development countries, this study demonstrates that both ageing and obesity contribute to an increase in osteoarthritis prevalence.

AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION (2023)

Add to Collection

Review Multidisciplinary Sciences

Beyond mechanical loading: The metabolic contribution of obesity in osteoarthritis unveils novel therapeutic targets

Basma H. Sobieh, Hala O. El-Mesallamy, Dina H. Kassem

Summary: Osteoarthritis (OA) is a prevalent progressive disease frequently associated with obesity. Recent findings have revealed the important role of adipose tissue in OA pathogenesis, shifting the perspective from aging and mechanical stress to metabolic effects of obesity on cartilage tissue. Adipokines such as metrnl and retinol-binding protein 4 (RBP4) have emerged as significant mediators in the development of OA. This review summarizes the latest research on the metabolic contribution of obesity in OA pathogenesis, with a focus on dyslipidemia, insulin resistance, and adipokines.

HELIYON (2023)

Add to Collection

Article Orthopedics

Footwear, foot orthoses and strengthening exercises for the non-surgical management of hallux valgus: protocol for a randomised pilot and feasibility trial

Hylton B. Menz, Polly Q. Lim, Sheree E. Hurn, Karen J. Mickle, Andrew K. Buldt, Matthew P. Cotchett, Edward Roddy, Anita E. Wluka, Bircan Erbas, Shannon E. Munteanu

Summary: This study aims to evaluate the effectiveness of a multifaceted non-surgical intervention for reducing pain associated with hallux valgus and to determine the feasibility of conducting a fully-powered randomised trial.

JOURNAL OF FOOT AND ANKLE RESEARCH (2022)

Add to Collection

Meeting Abstract Rheumatology

EFFICACY OF CORTICOSTEROIDS FOR HAND OSTEOARTHRITIS - A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

M. Estee, F. Cicuttini, M. Page, A. Butala, A. Wluka, S. M. Hussain, Y. Wang

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Meeting Abstract Rheumatology

EFFICACY OF TUMOR NECROSIS FACTOR INHIBITORS IN HAND OSTEOARTHRITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

M. Estee, F. Cicuttini, M. Page, A. Wluka, Y. Wang

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Meeting Abstract Rheumatology

EFFECT OF ATORVASTATIN ON SKELETAL MUSCLES OF PATIENTS WITH KNEE OSTEOARTHRITIS: POST-HOC ANALYSIS OF A RANDOMISED CONTROLLED TRIAL

Y. Lim, F. Cicuttini, A. Wluka, G. Jones, C. Hill, A. Forbes, A. Tonkin, S. Berezovskaya, L. Tan, C. Ding, Y. Wang

ANNALS OF THE RHEUMATIC DISEASES (2022)

Add to Collection

Article Rheumatology

Association between popliteal artery wall thickness and structural progression in patients with symptomatic knee osteoarthritis

Yuanyuan Wang, Ega Wirayoda Pontoh, Sultana Monira Hussain, Yuan Z. Lim, Graeme Jones, Catherine L. Hill, Anita E. Wluka, Andrew Tonkin, Changhai Ding, Flavia M. Cicuttini

Summary: This study found evidence for the involvement of vascular pathology in the progression of knee osteoarthritis and suggested that targeting atherosclerosis could improve outcomes in knee osteoarthritis.

RHEUMATOLOGY (2023)

Add to Collection

Article Rheumatology

Associations Between Dietary Intake of Vitamin K and Changes in Symptomatic and Structural Changes in Patients With Knee Osteoarthritis

Zetao Liao, Jun Chang, Zhaohua Zhu, Weiyu Han, Tao Meng, Shuang Zheng, Liudan Tu, Benny Antony, Tania Winzenberg, Anita E. Wluka, Flavia Cicuttini, Changhai Ding

Summary: The study examined the associations between dietary vitamin K intake and changes in knee symptoms and structures in patients with knee osteoarthritis (OA). The results showed that higher vitamin K intake was associated with a decrease in knee symptoms over 24 months. However, there was no overall association between vitamin K intake and changes in MRI features.

ARTHRITIS CARE & RESEARCH (2023)

Add to Collection

Article Peripheral Vascular Disease

Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication

Sultana Monira Hussain, Michael E. Ernst, Anna L. Barker, Karen L. Margolis, Christopher M. Reid, Johannes T. Neumann, Andrew M. Tonkin, Thao Le Thi Phuong, Lawrence J. Beilin, Thao Pham, Enayet K. Chowdhury, Flavia M. Cicuttini, Julia F. M. Gilmartin-Thomas, Prudence R. Carr, John J. McNeil

Summary: Long-term variability in mean arterial pressure is associated with an increased risk of falls in frail or prefrail individuals taking antihypertensive medications. Beta-blocker monotherapy is associated with a higher risk of falls compared to calcium channel blockers.

HYPERTENSION (2022)

Add to Collection

Article Chemistry, Analytical

Smartphone-Based Ecological Momentary Assessment for Collecting Pain and Function Data for Those with Low Back Pain

Ekjyot Kaur, Pari Delir Haghighi, Flavia M. Cicuttini, Donna M. Urquhart

Summary: This study demonstrates the feasibility of using smartphone-based EMA for collecting pain and function data. It highlights the advantages of EMA compared to traditional methods and emphasizes its acceptability and potential for personalized management of low back pain. The findings of this study are important for improving the treatment of low back pain.

SENSORS (2022)

Add to Collection

Article Medicine, General & Internal

Functional Outcomes Following Hip Replacement in Community-Dwelling Older Adults

Yuanyuan Wang, Alice Owen, Angus Franks, Ilana Ackerman, Sharyn M. Fitzgerald, Susan Liew, Robyn L. Woods, Anita E. Wluka, John J. McNeil, Flavia M. Cicuttini

Summary: Hip replacement surgery can significantly improve physical function in older adults, and the degree of preoperative physical impairment is an important indicator for predicting surgical outcomes.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Orthopedics

Trajectories of body mass index from early adulthood to late midlife and incidence of total knee arthroplasty for osteoarthritis: findings from a prospective cohort study

S. M. Hussain, I. N. Ackerman, Y. Wang, D. R. English, A. E. Wluka, G. G. Giles, F. M. Cicuttini

Summary: The study aims to investigate the association between body mass index (BMI) trajectories from early adulthood to late midlife and the risk of total knee arthroplasty (TKA) for osteoarthritis. The results suggest that weight gain increases the risk of TKA, and weight reduction may play a significant role in preventing TKA.

OSTEOARTHRITIS AND CARTILAGE (2023)

Add to Collection

Review Orthopedics

Association between weight gain and knee osteoarthritis: a systematic review

P. Solanki, S. M. Hussain, J. Abidi, J. Cheng, J. L. Fairley, M. J. Page, F. M. Cicuttini, A. E. Wluka

Summary: This study conducted a systematic review and data synthesis, showing that weight gain in adults is associated with increased clinical and structural KOA and TKR. Preventing weight gain should be considered to improve outcomes in KOA.

OSTEOARTHRITIS AND CARTILAGE (2023)

Add to Collection

Article Rheumatology

Neuropathic Pain Associated With First Metatarsophalangeal Joint Osteoarthritis: Frequency and Associated Factors

Hylton B. B. Menz, Jamie J. J. Allan, Andrew K. K. Buldt, Karl B. B. Landorf, Flavia M. M. Cicuttini, Edward Roddy, Shannon E. E. Munteanu

Summary: This study aimed to determine whether neuropathic pain is a feature of first metatarsophalangeal (MTP) joint osteoarthritis (OA). By comparing pain questionnaire results and related factors, the study found that a significant proportion of individuals with first MTP joint OA experience neuropathic pain, which may partly explain the suboptimal responses to commonly used treatments. Screening for neuropathic pain may be useful in selecting targeted interventions and improving clinical outcomes.

ARTHRITIS CARE & RESEARCH (2023)

Add to Collection

Review Medicine, General & Internal

Patient-Reported Outcomes following Total Knee Replacement in Patients Aged 65 Years and Over-A Systematic Review

Nicholas Woodland, Antony Takla, Mahnuma Mahfuz Estee, Angus Franks, Mansi Bhurani, Susan Liew, Flavia M. Cicuttini, Yuanyuan Wang

Summary: This systematic review evaluated the patient-reported outcomes following total knee replacement in individuals aged 65 years and older. The study found that TKR can reduce pain, improve function, and increase the quality of life for older individuals. Patients generally reported overall satisfaction with the results of the surgery.

JOURNAL OF CLINICAL MEDICINE (2023)

Add to Collection

Article Orthopedics

Nonsurgical management of hallux valgus: findings of a randomised pilot and feasibility trial

Hylton B. Menz, Polly Q. X. Lim, Sheree E. Hurn, Karen J. Mickle, Andrew K. Buldt, Matthew P. Cotchett, Edward Roddy, Anita E. Wluka, Bircan Erbas, Mehak Batra, Shannon E. Munteanu

Summary: This study aimed to evaluate the effectiveness of a nonsurgical intervention for reducing pain associated with hallux valgus and determine the feasibility of conducting a randomized trial. The results showed that the current intervention is not feasible, primarily due to low adherence and the impact of COVID-19.

JOURNAL OF FOOT AND ANKLE RESEARCH (2023)

Add to Collection

Article Rheumatology

Negative back beliefs are associated with increased odds of low back pain and disability: a 10-year cohort study in men

Mahnuma M. Estee, Yuanyuan Wang, Stephane Heritier, Donna M. Urquhart, Flavia M. Cicuttini, Mark A. Kotowicz, Sharon L. Brennan-Olsen, Julie A. Pasco, Anita E. Wluka

Summary: A study conducted on men over a 10-year period found that negative beliefs regarding back pain were associated with an increased likelihood of developing high-intensity pain and/or high disability.

RHEUMATOLOGY (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.