Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells

Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

(2022) Siddhartha Das Pramanik et al.   Frontiers in Chemistry

Strategies to Design Selective Histone Deacetylase Inhibitors

(2021) Wolfgang Sippl et al.   ChemMedChem

Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity

(2021) Hany S. Ibrahim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A short guide to histone deacetylases including recent progress on class II enzymes

(2020) Suk-Youl Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Identifying drug targets in tissues and whole blood with thermal-shift profiling

(2020) Jessica Perrin et al.   NATURE BIOTECHNOLOGY

Nitroreductase‐Mediated Release of Inhibitors of Lysine‐Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

(2020) Eva‐Maria Herrlinger et al.   CHEMBIOCHEM

Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)

(2020) Ewen D.D. Calder et al.   TETRAHEDRON

Role of Histone Deacetylases in Carcinogenesis: Potential Role in Cholangiocarcinoma

(2020) Kishor Pant et al.   Cells

Histone deacetylase inhibitor based prodrugs

(2020) Wenli Fan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Update of HDAC Inhibitors in Lymphoma

(2020) I-Chung Chen et al.   Frontiers in Cell and Developmental Biology

One-Atom Substitution Enables Direct and Continuous Monitoring of Histone Deacylase Activity

(2019) Matthes Zessin et al.   BIOCHEMISTRY

Zinc binding groups for histone deacetylase inhibitors

(2018) Lei Zhang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Cell-Specific Chemical Delivery Using a Selective Nitroreductase–Nitroaryl Pair

(2018) Todd D. Gruber et al.   ACS Chemical Biology

Targeting the hypoxic fraction of tumours using hypoxia-activated prodrugs

(2016) Roger M. Phillips   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs

(2016) Claudia Karnthaler-Benbakka et al.   ChemMedChem

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat

(2016) Isabelle Becher et al.   Nature Chemical Biology

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Self-Immolative Spacers: Kinetic Aspects, Structure-Property Relationships, and Applications

(2015) Ahmed Alouane et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

(2015) E. M. Williams et al.   BIOCHEMICAL JOURNAL

Why Hydroxamates May Not Be the Best Histone Deacetylase Inhibitors-What Some May Have Forgotten or Would Rather Forget?

(2015) Sida Shen et al.   ChemMedChem

Organic Carbamates in Drug Design and Medicinal Chemistry

(2015) Arun K. Ghosh et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Prodrug Approach: A Successful Tool for Improving Drug Solubility

(2015) Daniela Jornada et al.   MOLECULES

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Small Molecule Inhibitors of Zinc-dependent Histone Deacetylases

(2013) Florence F. Wagner et al.   Neurotherapeutics

Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

(2012) Chris J. Vickers et al.   ACS Medicinal Chemistry Letters

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Prodrugs for Targeted Tumor Therapies: Recent Developments in ADEPT, GDEPT and PMT

(2011) Lutz F. Tietze et al.   CURRENT PHARMACEUTICAL DESIGN

Synthesis and biological evaluation of glucuronide prodrugs of the histone deacetylase inhibitor CI-994 for application in selective cancer chemotherapy

(2008) Mickaël Thomas et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Histone deacetylase inhibitors in cancer therapy

(2008) Min-Jung Lee et al.   CURRENT OPINION IN ONCOLOGY