Cardiac complications in thalassemia throughout the lifespan: Victories and challenges

Overall and complication‐free survival in a large cohort of patients with β ‐thalassemia major followed over 50 years

(2023) Gian Luca Forni et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mortality in β-thalassemia patients with confirmed pulmonary arterial hypertension on right heart catheterization

(2022) Valeria M Pinto et al.   BLOOD

Atrial Fibrillation in β-Thalassemia: Overview of Mechanism, Significance and Clinical Management

(2022) Michele Malagù et al.   Biology-Basel

Pulmonary hypertension in thalassemia: a call to action

(2022) John C. Wood   BLOOD

2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive Summary

(2022) Paul A. Heidenreich et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Luspatercept, a two‐edged sword in beta‐thalassemia‐associated paravertebral extramedullary hematopoietic masses (EHMs)

(2022) Ferras Alashkar et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies

(2021) Kazunori Omote et al.   Annual Review of Medicine

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia

(2020) M. Domenica Cappellini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deferiprone increases endothelial nitric oxide synthase phosphorylation and nitric oxide production

(2018) Thanaporn Sriwantana et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Left Ventricular Diastolic Dysfunction in β-Thalassemia Major with Heart Failure

(2018) Luigi Mancuso et al.   HEMOGLOBIN

National registry of hemoglobinopathies in Greece: updated demographics, current trends in affected births, and causes of mortality

(2018) Ersi Voskaridou et al.   ANNALS OF HEMATOLOGY

Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction

(2018) Wasinee Kheansaard et al.   Scientific Reports

Haemodynamic definitions and updated clinical classification of pulmonary hypertension

(2018) Gérald Simonneau et al.   EUROPEAN RESPIRATORY JOURNAL

Red blood cell-derived microparticles: An overview

(2016) Maxwell Westerman et al.   BLOOD CELLS MOLECULES AND DISEASES

Pulmonary hypertension in well-transfused thalassemia major patients

(2015) Antonella Meloni et al.   BLOOD CELLS MOLECULES AND DISEASES

Synergistic intracellular iron chelation combinations: mechanisms and conditions for optimizing iron mobilization

(2015) Evangelia Vlachodimitropoulou Koumoutsea et al.   BRITISH JOURNAL OF HAEMATOLOGY

Myocardial fibrosis by late gadolinium enhancement cardiac magnetic resonance and hepatitis C virus infection in thalassemia major patients

(2015) Alessia Pepe et al.   Journal of Cardiovascular Medicine

The deferiprone and deferasirox combination is efficacious in iron overloaded patients with β-thalassemia major: A prospective, single center, open-label study

(2015) Sidharth Totadri et al.   PEDIATRIC BLOOD & CANCER

Efficacy and safety of sildenafil for the treatment of severe pulmonary hypertension in patients with hemoglobinopathies: results from a long-term follow up

(2014) G. Derchi et al.   HAEMATOLOGICA

The pathophysiological relationship and clinical significance of left atrial function and left ventricular diastolic dysfunction in β-thalassemia major

(2013) Anna G. Kostopoulou et al.   AMERICAN JOURNAL OF HEMATOLOGY

Twice daily deferasirox significantly improves clinical efficacy in transfusion dependent thalassaemias who were inadequate responders to standard once daily dose

(2013) Bunchoo Pongtanakul et al.   BLOOD CELLS MOLECULES AND DISEASES

Cardiovascular Function and Treatment in β-Thalassemia Major

(2013) Dudley J. Pennell et al.   CIRCULATION

Assessment of left ventricular and atrial diastolic function using two-dimensional (2D) strain imaging in patients with β-thalassemia major

(2013) Alexandra G. Karamanou et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Sildenafil therapy in thalassemia patients with Doppler-defined risk of pulmonary hypertension

(2013) C. R. Morris et al.   HAEMATOLOGICA

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Combined chelation therapy with deferasirox and deferoxamine in thalassemia

(2012) Ashutosh Lal et al.   BLOOD CELLS MOLECULES AND DISEASES

Vascular Endothelial Dysfunction in β-Thalassemia Occurs Despite Increased eNOS Expression and Preserved Vascular Smooth Muscle Cell Reactivity to NO

(2012) Ekatherina Stoyanova et al.   PLoS One

The WHO Classification of Pulmonary Hypertension: A Case-Based Imaging Compendium

(2012) John J. Ryan et al.   Pulmonary Circulation

Electrocardiographic consequences of cardiac iron overload in thalassemia major

(2011) Jon Detterich et al.   AMERICAN JOURNAL OF HEMATOLOGY

Risk factors and mortality associated with an elevated tricuspid regurgitant jet velocity measured by Doppler-echocardiography in thalassemia: a Thalassemia Clinical Research Network report

(2011) C. R. Morris et al.   BLOOD

Dispersion of repolarization and beta-thalassemia major: the prognostic role of QT and JT dispersion for identifying the high-risk patients for sudden death

(2011) Vincenzo Russo et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Risk factors for pulmonary hypertension in patients with β thalassemia intermedia

(2011) Mehran Karimi et al.   European Journal of Internal Medicine

Relationship between labile plasma iron, liver iron concentration and cardiac response in a deferasirox monotherapy trial

(2011) J. C. Wood et al.   HAEMATOLOGICA

Elevated liver iron concentration is a marker of increased morbidity in patients with   thalassemia intermedia

(2011) K. M. Musallam et al.   HAEMATOLOGICA

Pulmonary hypertension in thalassemia

(2010) Claudia R. Morris et al.   Annals of the New York Academy of Sciences

The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores

(2010) J. C. Wood et al.   BLOOD

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension

(2010) N. Sundaram et al.   BLOOD

Nutritional deficiencies in iron overloaded patients with hemoglobinopathies

(2009) Susan Claster et al.   AMERICAN JOURNAL OF HEMATOLOGY

Efficacy of deferasirox in reducing and preventing cardiac iron overload in  -thalassemia

(2009) D. J. Pennell et al.   BLOOD

Deferasirox pharmacokinetics in patients with adequate versus inadequate response

(2009) D. Chirnomas et al.   BLOOD

Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major

(2009) A Pepe et al.   HEART

Cardiac Complications in Thalassemia Major

(2009) John C. Wood   HEMOGLOBIN

Longitudinal analysis of heart and liver iron in thalassemia major

(2008) L. J. Noetzli et al.   BLOOD

Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 

(2008) N. Patel et al.   BLOOD

Effect of deferasirox (ICL670) on arterial function in patients with beta-thalassaemia major

(2008) Y. F. Cheung et al.   BRITISH JOURNAL OF HAEMATOLOGY

Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major

(2008) John C. Wood et al.   BRITISH JOURNAL OF HAEMATOLOGY

Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major

(2008) W. Li et al.   HAEMATOLOGICA