Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease

Distinct spatiotemporal subtypes of amyloid deposition are associated with diverging disease profiles in cognitively normal and mild cognitive impairment individuals

(2023) Yuqing Sun et al.   Translational Psychiatry

APOE ε4 associates with microglial activation independently of Aβ plaques and tau tangles

(2023) João Pedro Ferrari-Souza et al.   Science Advances

Spatial-Temporal Patterns of β-Amyloid Accumulation

(2022) Lyduine E. Collij et al.   NEUROLOGY

Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading

(2022) Wha Jin Lee et al.   NEURON

Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes

(2022) Victor Montal et al.   Science Translational Medicine

APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression

(2022) Aylin Dincer et al.   Science Translational Medicine

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

(2022) Alexa Pichet Binette et al.   Nature Communications

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

(2021) Justin S. Sanchez et al.   Science Translational Medicine

Four distinct trajectories of tau deposition identified in Alzheimer’s disease

(2021) Jacob W. Vogel et al.   NATURE MEDICINE

Abnormal tau in amyloid PET negative individuals

(2021) Bora Yoon et al.   NEUROBIOLOGY OF AGING

An atlas of the protein-coding genes in the human, pig, and mouse brain

(2020) Evelina Sjöstedt et al.   SCIENCE

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

Association of enlarged perivascular spaces and measures of small vessel and Alzheimers disease

(2020) Eske Christiane Gertje et al.   NEUROLOGY

Functional connectivity associated with tau levels in ageing, Alzheimer’s, and small vessel disease

(2019) Nicolai Franzmeier et al.   BRAIN

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

(2019) Michael J Pontecorvo et al.   BRAIN

Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo

(2018) Sarah L DeVos et al.   BRAIN

Spatial analysis and high resolution mapping of the human whole-brain transcriptome for integrative analysis in neuroimaging

(2018) Gregor Gryglewski et al.   NEUROIMAGE

Comparing18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease

(2018) Niklas Mattsson et al.   NEUROLOGY

Functional Brain Networks Are Dominated by Stable Group and Individual Factors, Not Cognitive or Daily Variation

(2018) Caterina Gratton et al.   NEURON

Neurogenetic contributions to amyloid beta and tau spreading in the human cortex

(2018) Jorge Sepulcre et al.   NATURE MEDICINE

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

(2017) Anne Maass et al.   NEUROIMAGE

Precision Functional Mapping of Individual Human Brains

(2017) Evan M. Gordon et al.   NEURON

Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

(2017) Sebastian Palmqvist et al.   Nature Communications

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease

(2017) Chenjie Xia et al.   JAMA Neurology

Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks

(2017) Oskar Hansson et al.   Frontiers in Neuroscience

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy

(2016) Liang Wang et al.   JAMA Neurology

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015

(2015) William J. Jagust et al.   Alzheimers & Dementia

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation

(2015) Sara Calafate et al.   Cell Reports

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

Automated Quantification of 18F-Flutemetamol PET Activity for Categorizing Scans as Negative or Positive for Brain Amyloid: Concordance with Visual Image Reads

(2014) L. Thurfjell et al.   JOURNAL OF NUCLEAR MEDICINE

Implementation and Validation of an Adaptive Template Registration Method for 18F-Flutemetamol Imaging Data

(2013) R. Lundqvist et al.   JOURNAL OF NUCLEAR MEDICINE

Resting-state fMRI in the Human Connectome Project

(2013) Stephen M. Smith et al.   NEUROIMAGE

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

FreeSurfer

(2012) Bruce Fischl   NEUROIMAGE

The Allen Human Brain Atlas

(2012) Elaine H. Shen et al.   TRENDS IN NEUROSCIENCES

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

FSL

(2011) Mark Jenkinson et al.   NEUROIMAGE

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Complex network measures of brain connectivity: Uses and interpretations

(2009) Mikail Rubinov et al.   NEUROIMAGE

Alzheimer's Disease Neuroimaging Initiative (ADNI): Clinical characterization

(2009) R. C. Petersen et al.   NEUROLOGY