Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer

CD68+, but not stabilin-1+ tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human breast cancer

(2017) Mikhail Buldakov et al.   IMMUNOBIOLOGY

Hyaluronan carried by tumor-derived microvesicles induces IL-10 production in classical (CD14 ++ CD16 − ) monocytes via PI3K/Akt/mTOR-dependent signalling pathway

(2017) Marzena Lenart et al.   IMMUNOBIOLOGY

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

CCL2 and CCL5 Are Novel Therapeutic Targets for Estrogen-Dependent Breast Cancer

(2015) S. Svensson et al.   CLINICAL CANCER RESEARCH

Tissue-resident macrophages: then and now

(2015) Luke C. Davies et al.   IMMUNOLOGY

CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages

(2015) Takanori Kitamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

(2015) Sarah T. Boyle et al.   Molecular Cancer

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway

(2015) Christina Katanov et al.   Stem Cell Research & Therapy

Hyaluronan, Inflammation, and Breast Cancer Progression

(2015) Kathryn L. Schwertfeger et al.   Frontiers in Immunology

The Content and Size of Hyaluronan in Biological Fluids and Tissues

(2015) Mary K. Cowman et al.   Frontiers in Immunology

Macrophages are recruited to hypoxic tumor areas and acquire a Pro-Angiogenic M2-Polarized phenotype via hypoxic cancer cell derived cytokines Oncostatin M and Eotaxin

(2015) Chakrapani Tripathi et al.   Oncotarget

Resolution of acute inflammation bridges the gap between innate and adaptive immunity

(2014) J. Newson et al.   BLOOD

Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production

(2014) Laura W. Bowers et al.   BREAST CANCER RESEARCH AND TREATMENT

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors

(2014) Piotr Tymoszuk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Wound healing-like immune program facilitates postpartum mammary gland involution and tumor progression

(2014) Holly A. Martinson et al.   INTERNATIONAL JOURNAL OF CANCER

Prevalence of Childhood and Adult Obesity in the United States, 2011-2012

(2014) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Production of Type VI Collagen by Human Macrophages: A New Dimension in Macrophage Functional Heterogeneity

(2014) M. Schnoor et al.   JOURNAL OF IMMUNOLOGY

A rapid increase in macrophage-derived versican and hyaluronan in infectious lung disease

(2014) Mary Y. Chang et al.   MATRIX BIOLOGY

BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation

(2014) Michael W. Pickup et al.   Molecular Oncology

Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis

(2014) Laura Bonapace et al.   NATURE

Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations

(2014) Marja Lohela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Collagen VI and Hyaluronan: The Common Role in Breast Cancer

(2014) Evgenia Karousou et al.   Biomed Research International

Macrophage Phenotype in the Mammary Gland Fluctuates over the Course of the Estrous Cycle and Is Regulated by Ovarian Steroid Hormones1

(2013) Leigh J. Hodson et al.   BIOLOGY OF REPRODUCTION

CX3CL1 expression is associated with poor outcome in breast cancer patients

(2013) Julia Y. S. Tsang et al.   BREAST CANCER RESEARCH AND TREATMENT

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

MUC4-induced nuclear translocation of β-catenin: A novel mechanism for growth, metastasis and angiogenesis in pancreatic cancer

(2013) Xiaofei Zhi et al.   CANCER LETTERS

Twist1 Induces CCL2 and Recruits Macrophages to Promote Angiogenesis

(2013) J. M. Low-Marchelli et al.   CANCER RESEARCH

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Activation of a positive feedback loop involving IL-6 and aromatase promotes intratumoral 17β-estradiol biosynthesis in endometrial carcinoma microenvironment

(2013) Qi Che et al.   INTERNATIONAL JOURNAL OF CANCER

M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway

(2013) Daniel H. Madsen et al.   JOURNAL OF CELL BIOLOGY

Origin of monocytes and macrophages in a committed progenitor

(2013) Jan Hettinger et al.   NATURE IMMUNOLOGY

Monocyte Chemoattractant Protein-1/CCL2 Produced by Stromal Cells Promotes Lung Metastasis of 4T1 Murine Breast Cancer Cells

(2013) Teizo Yoshimura et al.   PLoS One

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages Promote Fibroblast Growth Factor Receptor-Driven Tumor Cell Migration and Invasion in a Cxcr2-Dependent Manner

(2012) L. R. Bohrer et al.   MOLECULAR CANCER RESEARCH

IFN-α-driven CCL2 production recruits inflammatory monocytes to infection site in mice

(2012) C D Conrady et al.   Mucosal Immunology

Fibroblast Growth Factor Receptor 1 Activation in Mammary Tumor Cells Promotes Macrophage Recruitment in a CX3CL1-Dependent Manner

(2012) Johanna R. Reed et al.   PLoS One

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression

(2011) Xuezheng Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution

(2011) J. O'Brien et al.   DEVELOPMENT

Tumour-infiltrating macrophages and clinical outcome in breast cancer

(2011) S M A Mahmoud et al.   JOURNAL OF CLINICAL PATHOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2

(2011) Traci R Lyons et al.   NATURE MEDICINE

Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma

(2011) Manuela Liguori et al.   Cancers

Alternatively Activated Macrophages and Collagen Remodeling Characterize the Postpartum Involuting Mammary Gland across Species

(2010) Jenean O'Brien et al.   AMERICAN JOURNAL OF PATHOLOGY

Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome

(2010) Michael J. Campbell et al.   BREAST CANCER RESEARCH AND TREATMENT

Macrophage Expression of Hypoxia-Inducible Factor-1  Suppresses T-Cell Function and Promotes Tumor Progression

(2010) A. L. Doedens et al.   CANCER RESEARCH

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Proinflammatory Cytokines in Breast Cancer: Mechanisms of Action and Potential Targets for Therapeutics

(2010) Jodi E. Goldberg et al.   CURRENT DRUG TARGETS

Proinflammatory cytokines underlying the inflammation of Crohnʼs disease

(2010) Warren Strober et al.   CURRENT OPINION IN GASTROENTEROLOGY

Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium

(2010) A. C. L. Chua et al.   DEVELOPMENT

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

s-SHIP promoter expression marks activated stem cells in developing mouse mammary tissue

(2010) L. Bai et al.   GENES & DEVELOPMENT

Relationship of Time Since Childbirth and Other Pregnancy Factors to Premenopausal Breast Cancer Prognosis

(2010) Linda Dodds et al.   OBSTETRICS AND GYNECOLOGY

Molecular Mechanisms Guiding Embryonic Mammary Gland Development

(2010) P. Cowin et al.   Cold Spring Harbor Perspectives in Biology

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

The inflammatory chemokines CCL2 and CCL5 in breast cancer

(2008) Gali Soria et al.   CANCER LETTERS

Mouse hematopoietic stem cell identification and analysis

(2008) Grant A. Challen et al.   CYTOMETRY PART A

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Fragments of extracellular matrix as mediators of inflammation

(2007) T ADAIRKIRK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY