Article
Dentistry, Oral Surgery & Medicine
Ken Okabayashi, Yuki Wakao, Takanori Narita
Summary: This study focused on the relationship between the secretion of accumulated intracellular sIgA and beta-adrenergic receptor stimulation in submandibular gland cells. The results showed that stimulation of beta receptors resulted in increased secretion of sIgA, demonstrating the autonomic modulation of mucosal immunity.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Behavioral Sciences
Rachel R. Kessler, Patricia A. Schiml, Sean M. McGraw, Erin N. Tomlin, Mikayla J. Hoeferlin, Terrence Deak, Michael B. Hennessy
Summary: Early-life attachment disruption increases vulnerability for stress-related mental disorders through sensitizing neuroinflammatory signaling. Studies with guinea pig pups showed that sympathetic nervous system activation and cortisol elevations during early stress were not sufficient to account for the sensitization process of depressive-like behavior and fever. The processes mediating sensitization of neuroinflammatory-based depressive-like behavior in developing guinea pigs appear to differ from those in adults.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2023)
Review
Physiology
John Q. Yap, Jaroslava Seflova, Ryan Sweazey, Pablo Artigas, Seth L. Robia
Summary: The FXYD proteins are crucial regulatory factors that modulate NKA activity by interacting with it. Recent advances in research have expanded our understanding of the role of FXYD proteins in physiological processes, including their structure, function, and potential implications.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
R. K. Bugrov, A. M. Kuptsova, N. Ziyatdinova, T. L. Zefrov
Summary: In this study, we investigated the effects of alpha(2)-adrenoreceptor activation after I-f-current blockade in Langendorff-isolated rat hearts with myocardial infarction. The results showed that alpha(2)-adrenoreceptor stimulation reduced myocardial inotropy, increased heart rate, and decreased coronary flow.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Endocrinology & Metabolism
Dong Hwee Son, Khanh Doan, Dong Joo Yang, Ji Su Sun, Seul Ki Kim, Namju Kang, Jung Yun Kang, Ji-Hye Paik, Ronald A. DePinho, Yun-Hee Choi, Dong Min Shin, Ki Woo Kim
METABOLISM-CLINICAL AND EXPERIMENTAL
(2019)
Article
Endocrinology & Metabolism
Aran Son, Namju Kang, Sue Young Oh, Ki Woo Kim, Shmuel Muallem, Yu-Mi Yang, Dong Min Shin
JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
Review
Biochemistry & Molecular Biology
Jung Yun Kang, Namju Kang, Yu-Mi Yang, Jeong Hee Hong, Dong Min Shin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Soyoung Hwang, Peter Chang-Whan Lee, Dong Min Shin, Jeong Hee Hong
Summary: Spinophilin plays a crucial role in modulating the junctional network and cellular migration in lung cancer cells, affecting invasive ability and transporter activity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Sue Young Oh, Namju Kang, Jung Yun Kang, Ki Woo Kim, Jong-Hoon Choi, Yu-Mi Yang, Dong Min Shin
Summary: This study revealed that Sestrin2 plays a crucial role in bone homeostasis and osteoclast differentiation by regulating NFATc1 and the TRAF6/p62 interaction in the RANKL-RANK-TRAF6 signaling pathway. The deletion of Sestrin2 led to a decrease in osteoclast differentiation and function, as well as reduced bone mass, suggesting its novel role in bone metabolism.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Hyun Jin Kim, Jiae Lee, Gong-Rak Lee, Narae Kim, Hye In Lee, Minjeong Kwon, Nam Young Kim, Jin Ha Park, Ye Hee Kang, Hyeong Ju Song, TaeSoo Kim, Dong Min Shin, Woojin Jeong
Summary: FN inhibits osteoclastogenesis by blocking CaMKIV and calcineurin, reducing the risk of bone diseases like osteoporosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sukjoon Lee, Dongzi Chen, Munsu Park, Sunil Kim, Yoon Jeong Choi, Seok Jun Moon, Dong Min Shin, Ji Hyun Lee, Euiseong Kim
Summary: Single-cell RNA sequencing revealed distinct gene expression patterns in specific clusters of human dental pulp stem cells (hDPSCs) and human periodontal ligament stem cells (hPDLSCs). hDPSCs exhibited osteogenic and neurogenic cell populations, while hPDLSCs mainly comprised osteogenic and myofibroblastic populations. The results can serve as valuable resources for further research in dental therapeutics.
JOURNAL OF ENDODONTICS
(2022)
Article
Toxicology
Dongun Lee, Peter Chang-Whan Lee, Jeong Hee Hong, Dong Min Shin
Summary: The study found that 8-estradiol treatment attenuated the oxalate or bicarbonate transporting activities through SLC26A6 and enhanced cancer cell migration. Even in the presence of 8-estradiol treatment, increased SLC26A6 expression weakened cellular migration. These results suggest that 8-estradiol treatment enhances cancer cell migration by inhibiting SLC26A6 activity.
TOXICOLOGY IN VITRO
(2022)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: Small humanin-like peptide 2 (SHLP2), a mitochondrial-derived peptide, plays a crucial role in energy homeostasis. The study demonstrates that SHLP2 can protect mice from high-fat diet-induced obesity and improve insulin sensitivity. It activates pro-opiomelanocortin (POMC) neurons in the hypothalamus, which suppresses food intake and promotes thermogenesis. The researchers also discover that SHLP2 binds to and activates chemokine receptor 7 (CXCR7).
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Minjeong Ji, Hee Jung Ryu, Hyeon-Man Baek, Dong Min Shin, Jeong Hee Hong
Summary: The study found that modulation of the migratory module of fibroblast-like synoviocytes (FLSs) can attenuate the severity of rheumatoid arthritis (RA). The sodium bicarbonate cotransporter n1 (NBCn1) was identified in RA-FLSs and inhibiting NBCs reduced FLS migration and RA symptoms.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soyoung Hwang, Dong Min Shin, Jeong Hee Hong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Namju Kang, Ki Woo Kim, Dong Min Shin
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2019)