Drug Repurposing as an Antitumor Agent: Disulfiram-Mediated Carbonic Anhydrase 12 and Anion Exchanger 2 Modulation to Inhibit Cancer Cell Migration

An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis

(2018) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma

(2018) Atsushi Shiozaki et al.   Oncotarget

Chloride Influx of Anion Exchanger 2 Was Modulated by Calcium-Dependent Spinophilin in Submandibular Glands

(2018) Dongun Lee et al.   Frontiers in Physiology

Carbonic anhydrase inhibitors as emerging agents for the treatment and imaging of hypoxic tumors

(2018) Claudiu T. Supuran   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5

(2018) Soyoung Hwang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbonic anhydrase XII functions in health and disease

(2017) Abdul Waheed et al.   GENE

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms

(2017) Jon Celay et al.   HAEMATOLOGICA

Cell-surface marker discovery for lung cancer

(2017) Allison S. Cohen et al.   Oncotarget

Knockdown of anion exchanger 2 suppressed the growth of ovarian cancer cells via mTOR/p70S6K1 signaling

(2017) Li-Jun Zhang et al.   Scientific Reports

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms

(2017) Jon Celay et al.   HAEMATOLOGICA

Tumor metabolism, cancer cell transporters, and microenvironmental resistance

(2016) Khalid O. Alfarouk   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions

(2016) Yaping Yang et al.   SCANNING

Ion channels and transporters in metastasis

(2015) Christian Stock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Governing effect of regulatory proteins for Cl−/HCO3−exchanger 2 activity

(2015) Yon Soo Jeong et al.   Channels

The Na+/HCO3−Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

(2015) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3−secretion revealed by disease causing human mutation

(2015) Jeong Hee Hong et al.   JOURNAL OF PHYSIOLOGY-LONDON

Evaluation of CAIX and CAXII Expression in Breast Cancer at Varied O2 Levels: CAIX is the Superior Surrogate Imaging Biomarker of Tumor Hypoxia

(2015) Narges K. Tafreshi et al.   MOLECULAR IMAGING AND BIOLOGY

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK

(2012) Ling-Jun Song et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

(2011) Eliska Svastova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An agarose spot assay for chemotactic invasion

(2010) Helen Wiggins et al.   BIOTECHNIQUES

Reduction of anion exchanger 2 expression induces apoptosis of human hepatocellular carcinoma cells

(2009) Jin-Ming Hwang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY